Comparison of endoscopy and C-14 urea breath test in terms of helicobacter pylori positivity in patients admitted with complaints of dyspepsia

Yasemin Korkut; Türkan Kilit; İlknur Işık; Celal Kilit

doi:10.22391/920.182937

Research Article

Comparison of endoscopy and C-14 urea breath test in terms of helicobacter pylori positivity in patients admitted with complaints of dyspepsia

Year 2016, Volume: 1 Issue: 1, 9 - 12, 29.02.2016

Yasemin Korkut , Türkan Kilit , İlknur Işık Celal Kilit

https://doi.org/10.22391/920.182937

Cited By: 1

Abstract

Introduction: In this study, we aimed to compare Carbon-14 Urea Breath Test (C-14 UBT) and endoscopy in diagnosis of Helicobacter
pylori (HP) and show the availability of the C-14 UBT in follow-up.

Methods: We enrolled 183 patients who were admitted to Dumlupınar University Faculty of Medicine, Kütahya Evliya Çelebi
Education and Research Hospital between April 2012-February 2015 with dyspeptic complaints and C-14 UBT performed due to the
suspicion of HP infection. Patient records were analyzed retrospectively.

Results: We enrolled 183 patients with age range 7-71 years. The mean age was 31 ± 15 years and 129 of patients were female (7%),
and 54 were male (30%). According to the results of C-14 UBT, HP was negative in 77 of patients (42%), HP was probable in 2 of
patients (1%) and HP was positive in 104 patients (57%). There was no significant difference between HP positive and HP negative
groups in terms of age and gender. When compared the results of C-14 UBT with upper gastrointestinal system endoscopy, it was found
that there was no difference between the two methods for the determination of the HP positivity (p >0.05).

Conclusion: C-14 UBT is a reliable, noninvasive and practical test which can be used in the diagnosis of HP.

Keywords

Dyspepsia , Endoscopy , Gastrointestinal , Helicobacter Pylori , Breath Test

References

Dunn B E, Cohen H, Blaser M J. Helicobacter pylori. Clinical microbiology Reviews.1997; 720-741.
European Helicobacter pylori Study Group. Current European concepts in the management of Helicobacter pylori infection. The Maastricht consensus report. Gut. 1997;(41):8– 13.
Dooley CP. Background and historical considerations of Helicobacter pylori. Gastroenterology Clin. North Am. 1993;22(1):1–19.
National Institutes of Health Consensus Development Conference Statement 1994;(2):7-9.
Malfertheiner P, Megraud F, O’Morain C ve ark. Current concepts in the management of Helicobacter pylori infection. The Maastrich III Consensus Report. Gut 2007; 56:772-81.
Erdoğan AF, Turan İ, Gereklioğlu Ç ve ark. Aile hekimliği polikliniğinde dispeptik hastalarda Helicobacter pylori sıklığı. Türk Aile Hek Derg 2008;12(4):198-202.
Balon H, Gold CA, Dworkin HJ, McCormick VA, Freitas JE. Procedure guideline for carbon-14-urea breath test. The Journal of Nuclear Medicine 1998;39:2012-14.
Everhart J E. Recent developments in the epidemiology of Helicobacter pylori. Gastroenterology Clinics of North America. 2000;29(3):559–578.
Altındiş M, Özdemir M. Helicobacter Pylori ve Tanısı. Kocatepe Tıp Dergisi. 2003;2:1-12.
Selçukcan Aydın F, Demirkıran Urgancı N, Üzüm Yenici F. Pediatrik Yaş Grubunda Helikobakter Pilori Kaynaklı Gastrit Tanısında Kullanılan Yöntemlerin Karşılaştırılması Ve Tedavi Sonrası Takipte Noninvaziv Bir Test Olarak Üre Nefes Testinin Kullanılabilirliği. Düzce Tıp Dergisi 2011;13(1):6-14.
Altıntaş E, Ulu O, Sezgin O, Aydin O, Camdeviren H. Comparison of ranitidine, bismuth citrate, tetracycline and metronidazole with ranitidine, bismuth citrate and azithromycin for the eradication of Helicobacter pylori in patients resistant to PPI based triple therapy. Turk J Gastroenterol 2004;15:90-93.
Köksal AS, Önder FO, Torun S, Parlak E, Sayılır A, Tayfur O, et al. Twice a day quadruple therapy for the first-line treatment of Helicobacter pylori in an area with a high prevalence of background antibiotic resistance. Acta Gastroenterol Belg 2013;76:34-37.
Wong WM, Gu Q, Lam SK, Fung FM, Lai KC, Hu WH, et al. Randomized controlled study of rabeprazole, levofloxacin and rifabutin triple therapy vs. quadruple therapy as second-line treatment for Helicobacter pylori infection. Aliment Pharmacol Ther 2003;17:553-560.
Zheng Q, Chen WJ, Lu H, Sun QJ, Xiao SD. Comparison of the efficacy of triple versus quadruple therapy on the eradication of Helicobacter pylori and antibiotic resistance. J Dig Dis 2010;11:313-318.
Frenck RW Jr, Clemens J. Helicobacter in the developing world. Microbes Infect 2003;5:705-713.
Özbalcı G, Yürüker S, Tarım İ ve ark. Helikobakter pilori eradikasyonunda birinci basamak tedavi: bir cerrahi kliniğinin deneyimleri. Ulusal Cer Derg 2014;30:133-7.
Bingöl R. Helicobacter pylori Mikrobiyolojisi. 9. Türk Klinik ve Mikrobiyoloji İnfeksiyon Hastalıkları Kongresi, 3-8 Ekim, Antalya; Kongre Kitabı. 1999;51-55.
Georgopoulos SD, Papastergiou V, Karatapanis S. Current options for the treatment of Helicobacter pylori. Expert Opin Pharmacother 2013;14:211-223.
Mégraud F, Lehours P. Helicobacter pylori Detection and Antimicrobial Susceptibility Testing Clin Microbiol Rev. 2007;20(2):280–322.
Köksal AŞ, Oğuz D, Özden A. Türkiye’de birinci basamak sağlık kurumlarına başvuran hastalarda dispepsi görülme sıklığı. Akademik Gastroenteroloji Dergisi 2008;7(1):11-17.
Özaydın ANG. Türkiye’de Helicobacter pylori prevalans çalışması sonucu TURHEP çalışması. Panel II. Hepato-Gastroenteroloji Kongresi 2005.
Türkölmez S, Cayır D, Aydoğan F, Korkmaz M. The relationship of Helicobacter pylori positivity with age, sex, and ABO / rhesus blood groups in patients with gastrointestinal complaints in Turkey. Helicobacter 2007;12:244-50.
Duynhoven YTH, de Jonge R. Transmission of helicobacter pylori: A role for food? Bulletin of the World Health Organization 2001;79:455-60.

Dispepsi şikâyeti ile başvuran hastalarda helikobakter pilori pozitifliği açısından C-14 üre nefes testi ile endoskopinin karşılaştırılması

Year 2016, Volume: 1 Issue: 1, 9 - 12, 29.02.2016

Yasemin Korkut , Türkan Kilit , İlknur Işık Celal Kilit

https://doi.org/10.22391/920.182937

Cited By: 1

Abstract

Giriş: Bu çalışmada, Helikobakter Pilori (HP) tanısında Karbon-14 Üre Nefes Testini (C-14 ÜNT) endoskopi ile karşılaştırmayı ve
takipte C-14 ÜNT’nin kullanılabilirliğini göstermeyi amaçladık.

Yöntem: Çalışmaya Nisan 2012-Şubat 2015 tarihleri arasında Dumlupınar Üniversitesi Tıp Fakültesi Kütahya Evliya Çelebi Eğitim ve
Araştırma Hastanesine dispeptik şikayetlerle başvuran ve HP enfeksiyonu şüphesi ile C-14 ÜNT yapılan 183 hasta dahil edildi.
Hastaların kayıtları geriye dönük olarak incelendi.

Bulgular: Çalışmaya yaş aralığı 7-71 arasında değişen 183 hasta alındı. Yaş ortalaması 31±15 yıl idi ve hastaların 129’u kadın (%7),
54’ü erkekti (%30). C-14 ÜNT sonucunda hastaların 77’sinde (%42) HP negatif, 2’sinde (%1) HP şüpheli, 104 hastada (%57) HP
pozitifti. HP negatif ve HP pozitif gruplar arasında yaş ve cinsiyet bakımından anlamlı fark yoktu. C-14 ÜNT ile üst gastrointestinal
sistem endoskopi sonuçları karşılaştırıldığında, iki yöntem arasında HP pozitifliğinin tespiti açısından fark olmadığı tespit edildi
(p > 0.05).

Sonuç: C-14 ÜNT, HP tanısında kullanılabilecek güvenilir, noninvaziv ve pratik bir testtir

Keywords

Dispepsi , Endoskopi , Gastrointestinal , Helikobakter Pilori , Nefes Testleri

References

Dunn B E, Cohen H, Blaser M J. Helicobacter pylori. Clinical microbiology Reviews.1997; 720-741.
European Helicobacter pylori Study Group. Current European concepts in the management of Helicobacter pylori infection. The Maastricht consensus report. Gut. 1997;(41):8– 13.
Dooley CP. Background and historical considerations of Helicobacter pylori. Gastroenterology Clin. North Am. 1993;22(1):1–19.
National Institutes of Health Consensus Development Conference Statement 1994;(2):7-9.
Malfertheiner P, Megraud F, O’Morain C ve ark. Current concepts in the management of Helicobacter pylori infection. The Maastrich III Consensus Report. Gut 2007; 56:772-81.
Erdoğan AF, Turan İ, Gereklioğlu Ç ve ark. Aile hekimliği polikliniğinde dispeptik hastalarda Helicobacter pylori sıklığı. Türk Aile Hek Derg 2008;12(4):198-202.
Balon H, Gold CA, Dworkin HJ, McCormick VA, Freitas JE. Procedure guideline for carbon-14-urea breath test. The Journal of Nuclear Medicine 1998;39:2012-14.
Everhart J E. Recent developments in the epidemiology of Helicobacter pylori. Gastroenterology Clinics of North America. 2000;29(3):559–578.
Altındiş M, Özdemir M. Helicobacter Pylori ve Tanısı. Kocatepe Tıp Dergisi. 2003;2:1-12.
Selçukcan Aydın F, Demirkıran Urgancı N, Üzüm Yenici F. Pediatrik Yaş Grubunda Helikobakter Pilori Kaynaklı Gastrit Tanısında Kullanılan Yöntemlerin Karşılaştırılması Ve Tedavi Sonrası Takipte Noninvaziv Bir Test Olarak Üre Nefes Testinin Kullanılabilirliği. Düzce Tıp Dergisi 2011;13(1):6-14.
Altıntaş E, Ulu O, Sezgin O, Aydin O, Camdeviren H. Comparison of ranitidine, bismuth citrate, tetracycline and metronidazole with ranitidine, bismuth citrate and azithromycin for the eradication of Helicobacter pylori in patients resistant to PPI based triple therapy. Turk J Gastroenterol 2004;15:90-93.
Köksal AS, Önder FO, Torun S, Parlak E, Sayılır A, Tayfur O, et al. Twice a day quadruple therapy for the first-line treatment of Helicobacter pylori in an area with a high prevalence of background antibiotic resistance. Acta Gastroenterol Belg 2013;76:34-37.
Wong WM, Gu Q, Lam SK, Fung FM, Lai KC, Hu WH, et al. Randomized controlled study of rabeprazole, levofloxacin and rifabutin triple therapy vs. quadruple therapy as second-line treatment for Helicobacter pylori infection. Aliment Pharmacol Ther 2003;17:553-560.
Zheng Q, Chen WJ, Lu H, Sun QJ, Xiao SD. Comparison of the efficacy of triple versus quadruple therapy on the eradication of Helicobacter pylori and antibiotic resistance. J Dig Dis 2010;11:313-318.
Frenck RW Jr, Clemens J. Helicobacter in the developing world. Microbes Infect 2003;5:705-713.
Özbalcı G, Yürüker S, Tarım İ ve ark. Helikobakter pilori eradikasyonunda birinci basamak tedavi: bir cerrahi kliniğinin deneyimleri. Ulusal Cer Derg 2014;30:133-7.
Bingöl R. Helicobacter pylori Mikrobiyolojisi. 9. Türk Klinik ve Mikrobiyoloji İnfeksiyon Hastalıkları Kongresi, 3-8 Ekim, Antalya; Kongre Kitabı. 1999;51-55.
Georgopoulos SD, Papastergiou V, Karatapanis S. Current options for the treatment of Helicobacter pylori. Expert Opin Pharmacother 2013;14:211-223.
Mégraud F, Lehours P. Helicobacter pylori Detection and Antimicrobial Susceptibility Testing Clin Microbiol Rev. 2007;20(2):280–322.
Köksal AŞ, Oğuz D, Özden A. Türkiye’de birinci basamak sağlık kurumlarına başvuran hastalarda dispepsi görülme sıklığı. Akademik Gastroenteroloji Dergisi 2008;7(1):11-17.
Özaydın ANG. Türkiye’de Helicobacter pylori prevalans çalışması sonucu TURHEP çalışması. Panel II. Hepato-Gastroenteroloji Kongresi 2005.
Türkölmez S, Cayır D, Aydoğan F, Korkmaz M. The relationship of Helicobacter pylori positivity with age, sex, and ABO / rhesus blood groups in patients with gastrointestinal complaints in Turkey. Helicobacter 2007;12:244-50.
Duynhoven YTH, de Jonge R. Transmission of helicobacter pylori: A role for food? Bulletin of the World Health Organization 2001;79:455-60.

There are 23 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Original Research
Authors	Yasemin Korkut Türkan Kilit İlknur Işık Celal Kilit
Publication Date	February 29, 2016
Submission Date	February 29, 2016
Acceptance Date	April 4, 2016
Published in Issue	Year 2016 Volume: 1 Issue: 1

Cite

APA	Korkut, Y., Kilit, T., Işık, İ., Kilit, C. (2016). Comparison of endoscopy and C-14 urea breath test in terms of helicobacter pylori positivity in patients admitted with complaints of dyspepsia. Family Practice and Palliative Care, 1(1), 9-12. https://doi.org/10.22391/920.182937
AMA	Korkut Y, Kilit T, Işık İ, Kilit C. Comparison of endoscopy and C-14 urea breath test in terms of helicobacter pylori positivity in patients admitted with complaints of dyspepsia. Fam Pract Palliat Care. April 2016;1(1):9-12. doi:10.22391/920.182937
Chicago	Korkut, Yasemin, Türkan Kilit, İlknur Işık, and Celal Kilit. “Comparison of Endoscopy and C-14 Urea Breath Test in Terms of Helicobacter Pylori Positivity in Patients Admitted With Complaints of Dyspepsia”. Family Practice and Palliative Care 1, no. 1 (April 2016): 9-12. https://doi.org/10.22391/920.182937.
EndNote	Korkut Y, Kilit T, Işık İ, Kilit C (April 1, 2016) Comparison of endoscopy and C-14 urea breath test in terms of helicobacter pylori positivity in patients admitted with complaints of dyspepsia. Family Practice and Palliative Care 1 1 9–12.
IEEE	Y. Korkut, T. Kilit, İ. Işık, and C. Kilit, “Comparison of endoscopy and C-14 urea breath test in terms of helicobacter pylori positivity in patients admitted with complaints of dyspepsia”, Fam Pract Palliat Care, vol. 1, no. 1, pp. 9–12, 2016, doi: 10.22391/920.182937.
ISNAD	Korkut, Yasemin et al. “Comparison of Endoscopy and C-14 Urea Breath Test in Terms of Helicobacter Pylori Positivity in Patients Admitted With Complaints of Dyspepsia”. Family Practice and Palliative Care 1/1 (April2016), 9-12. https://doi.org/10.22391/920.182937.
JAMA	Korkut Y, Kilit T, Işık İ, Kilit C. Comparison of endoscopy and C-14 urea breath test in terms of helicobacter pylori positivity in patients admitted with complaints of dyspepsia. Fam Pract Palliat Care. 2016;1:9–12.
MLA	Korkut, Yasemin et al. “Comparison of Endoscopy and C-14 Urea Breath Test in Terms of Helicobacter Pylori Positivity in Patients Admitted With Complaints of Dyspepsia”. Family Practice and Palliative Care, vol. 1, no. 1, 2016, pp. 9-12, doi:10.22391/920.182937.
Vancouver	Korkut Y, Kilit T, Işık İ, Kilit C. Comparison of endoscopy and C-14 urea breath test in terms of helicobacter pylori positivity in patients admitted with complaints of dyspepsia. Fam Pract Palliat Care. 2016;1(1):9-12.