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Research Article
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Ailesinde nodüler guatr olan çocukların tiroid lezyon prevalansı

Year 2017, Volume: 2 Issue: 3, 16 - 21, 28.12.2017

Zuhal Aşık Hakan Aylanç

https://doi.org/10.22391/fppc.333879

Abstract

Giriş: Nodüler guatrın genetik
olarak kümelenmesi ile ilgili yeterli çalışma yoktur. Her ne kadar ikiz
çalışmaları genetik bir kümelenme göstermişse de, bu konuyla ilgili yapılmış
prospektif bir çalışma yoktur. Bu çalışmanın amacı ailesinde nodüler guatrı
olan çocuklardaki nodül prevelansının değerlendirilerek ailesel kümelenmenin
varlığının araştırılmasıdır.

Yöntem: Ailesinde nodüler guatr
tespit edilen ve edilmeyen çocukların tiroit ultrasonu ile değerlendirilerek
nodül prevelansı hesaplanmıştır.

Bulgular: Tüm çocukların 5’inde
(%3,4) nodüler guatr saptandı. Ailesinde nodüler guatr öyküsü olan çocukların
2’sinde (%2,5), kontrol grubundaki çocukların 3’ünde (%4,7) nodüler guatr
tespit edildi. 2 grup arasında istatistiksel olarak anlamlı fark saptanmadı.







Sonuç: Bu çalışma nodüler guatr
hastalığının ailesel yönünü araştıran ilk prospektif çalışmadır. Çalışmamızda
nodüler guatrlı hastaların çocuk kitlesi hedeflenmiştir. Yapılan istatistiksel
analiz sonucunda MNG’lı hastaların çocuklarında nodüler guatrın kümelenmediği
izlenmiştir.

Keywords

guatr tiroit nodülleri çocuk

References

  • 1. Mussa A, De Andrea M, Motta M, Mormile A, Palestini N, Corrias A. Predictors of Malignancy in Children with Thyroid Nodules. J Pediatr. 2015 Oct;167(4):886-892.
  • 2. Niedziela M. Pathogenesis, diagnosis and management of thyroid nodules in children. Endocr Relat Cancer 2006;13:427-53.
  • 3. Niedziela M. Thyroid nodules. Best Pract Res Clin Endocrinol Metab 2014;28:245-77.
  • 4. Dean DS, Gharib H. Epidemiology of thyroid nodules. Best Pract Res Clin Endocrinol Metab 2008;22:901-11.
  • 5. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, Mcıver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2009;19:1167-1214.
  • 6. Khurana KK, Labrador E, Izquıerdo R, Mesonero CE, Pısharodı LR. The role of fine-needle aspiration biopsy in the management of thyroid nodules in children, adolescents, and young adults: a multi-institutional study. Thyroid. 1999;9: 383-386.
  • 7. Gupta A, Ly S, Castroneves LA, Frates MC, Benson CB, Feldman HA, et al. A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. J Clin Endocrinol Metab 2013;98:3238-45.
  • 8. Corrıas A, Mussa A, Baronıo F, Arrıgo T, Salerno M, Segnı M, Vıgone MC, Gastaldı R, Zırıllı G, Tulı G, Beccarıa L, Iughettı L, Eınaudı S, Weber G, DE Luca F. Diagnostic features of thyroid nodules in pediatrics. Arch Pediatr Adolesc Med. 2010;164:714–719.
  • 9. Aghini-Lombardi F, Antonangelı L, Martıno E, Vıttı P, Maccherını D, Leolı F, Rago T, Grasso L, Valerıano R, Balestrıerı A, Pınchera A. The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. J Clin Endocrinol Metab 1999;84: 561–566.
  • 10. Hansen PS, Brıx TH, Bennedbaek FN, Bonnema SJ, Iachıne I, Kyvık KO, Hegedüs L. The relative importance of genetic and environmental factors in the etiology of thyroid nodularity: a study of healthy Danish twins. Clin Endocrinol (Oxf).2005; 62: 380-386.
  • 11. Taş F, Bulut S, Eğilmez H, Oztoprak I, Ergür AT, Candan F. Normal thyroid volume by ultrasonography in healthy children. Ann Trop Paediatr.2002;22: 375-379.
  • 12. CASTRO, M.R., GHARİB, H. (2000). Thyroid nodules and cancer. Postgrad Med. 107: 113-124.
  • 13. Dıttmar M, Lıbıch C, Brenzel T, Kahaly GJ. Increased familial clustering of autoimmune thyroid diseases. Horm Metab Res. 2011;43: 200-204.
  • 14. Sadowskı SM, He M, Gesuwan K, Gulatı N, Celi F, Merıno M, Nilubol N, Kebebew E. Prospective screening in familial nonmedullary thyroid cancer. Surgery. 2013;154:1194-1198.
  • 15. Langer P, Tajtáková M, Bohov P, Klımes I. Possible role of genetic factors in thyroid growth rate and in the assessment of upper limit of normal thyroid volume in iodine-replete adolescents. Thyroid. 1999;9: 557-562.
  • 16. Halac I, Zimmerman D. Thyroid nodules and cancers in children. Endocrinol Metab Clin North Am 2005;34: 725–774.
  • 17. Baş VN, Aycan Z, Cetinkaya S, Uner C, Cavuşoğlu YH, Arda N. Thyroid nodules in children and adolescents: a single institution's experience. J Pediatr Endocrinol Metab. 2012;25: 633-638.
  • 18. Arda IS, Yıldırım S, Demırhan B, Fırat S. Fine needle aspiration biopsy of thyroid nodules. Arch Dis Child 2001;85: 313-317.
  • 19. Erdoğan G, Erdoğan MF, Delange F, Sav H, Güllü S, Kamel N. Moderate to severe iodine deficiency in three endemic goitre areas from the Black Sea region and the capital of Turkey. Eur J Epidemiol 2000;16:1131-1134.
  • 20. Erdoğan MF, Demır O, Emral R, Kamel AN, Erdoğan G. More than a decade of iodine prophylaxis is needed to eradicate goiter among school age children in a moderately iodine-deficient region. Thyroid. 2009;19: 265-268.

The prevalence of thyroid nodules in children with family history for nodular goiter

Year 2017, Volume: 2 Issue: 3, 16 - 21, 28.12.2017

Zuhal Aşık Hakan Aylanç

https://doi.org/10.22391/fppc.333879

Abstract

Introduction: There is insufficient study on the genetic
clustering of nodular goiter. Although twin studies have proved genetic
clustering, there is no prospective study on this topic. The aim of this study
is to investigate the existence of familial clustering by evaluating the
prevalence of thyroid nodules in the children of families with nodular goiter.

Methods: The prevalence of thyroid nodules was calculated by
evaluating the thyroid ultrasound results of children from families with and
without nodular goiter.

Results: Nodular goiter was detected in 5 children (3.4%), 2
(2.5%) from families with nodular goiter history and 3 (4.7%) from the control
group. There was no statistically significant difference between these two
groups.

Conclusions: This is the first prospective study to investigate
the familial aspect of nodular goiter disease. In our study, children with
nodular goiter were the target group. Following statistical analysis,
clustering of nodular goiter was observed in the children of patients with
multinodular goiter.








Keywords

goiter thyroid nodules children

References

  • 1. Mussa A, De Andrea M, Motta M, Mormile A, Palestini N, Corrias A. Predictors of Malignancy in Children with Thyroid Nodules. J Pediatr. 2015 Oct;167(4):886-892.
  • 2. Niedziela M. Pathogenesis, diagnosis and management of thyroid nodules in children. Endocr Relat Cancer 2006;13:427-53.
  • 3. Niedziela M. Thyroid nodules. Best Pract Res Clin Endocrinol Metab 2014;28:245-77.
  • 4. Dean DS, Gharib H. Epidemiology of thyroid nodules. Best Pract Res Clin Endocrinol Metab 2008;22:901-11.
  • 5. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, Mcıver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2009;19:1167-1214.
  • 6. Khurana KK, Labrador E, Izquıerdo R, Mesonero CE, Pısharodı LR. The role of fine-needle aspiration biopsy in the management of thyroid nodules in children, adolescents, and young adults: a multi-institutional study. Thyroid. 1999;9: 383-386.
  • 7. Gupta A, Ly S, Castroneves LA, Frates MC, Benson CB, Feldman HA, et al. A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. J Clin Endocrinol Metab 2013;98:3238-45.
  • 8. Corrıas A, Mussa A, Baronıo F, Arrıgo T, Salerno M, Segnı M, Vıgone MC, Gastaldı R, Zırıllı G, Tulı G, Beccarıa L, Iughettı L, Eınaudı S, Weber G, DE Luca F. Diagnostic features of thyroid nodules in pediatrics. Arch Pediatr Adolesc Med. 2010;164:714–719.
  • 9. Aghini-Lombardi F, Antonangelı L, Martıno E, Vıttı P, Maccherını D, Leolı F, Rago T, Grasso L, Valerıano R, Balestrıerı A, Pınchera A. The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. J Clin Endocrinol Metab 1999;84: 561–566.
  • 10. Hansen PS, Brıx TH, Bennedbaek FN, Bonnema SJ, Iachıne I, Kyvık KO, Hegedüs L. The relative importance of genetic and environmental factors in the etiology of thyroid nodularity: a study of healthy Danish twins. Clin Endocrinol (Oxf).2005; 62: 380-386.
  • 11. Taş F, Bulut S, Eğilmez H, Oztoprak I, Ergür AT, Candan F. Normal thyroid volume by ultrasonography in healthy children. Ann Trop Paediatr.2002;22: 375-379.
  • 12. CASTRO, M.R., GHARİB, H. (2000). Thyroid nodules and cancer. Postgrad Med. 107: 113-124.
  • 13. Dıttmar M, Lıbıch C, Brenzel T, Kahaly GJ. Increased familial clustering of autoimmune thyroid diseases. Horm Metab Res. 2011;43: 200-204.
  • 14. Sadowskı SM, He M, Gesuwan K, Gulatı N, Celi F, Merıno M, Nilubol N, Kebebew E. Prospective screening in familial nonmedullary thyroid cancer. Surgery. 2013;154:1194-1198.
  • 15. Langer P, Tajtáková M, Bohov P, Klımes I. Possible role of genetic factors in thyroid growth rate and in the assessment of upper limit of normal thyroid volume in iodine-replete adolescents. Thyroid. 1999;9: 557-562.
  • 16. Halac I, Zimmerman D. Thyroid nodules and cancers in children. Endocrinol Metab Clin North Am 2005;34: 725–774.
  • 17. Baş VN, Aycan Z, Cetinkaya S, Uner C, Cavuşoğlu YH, Arda N. Thyroid nodules in children and adolescents: a single institution's experience. J Pediatr Endocrinol Metab. 2012;25: 633-638.
  • 18. Arda IS, Yıldırım S, Demırhan B, Fırat S. Fine needle aspiration biopsy of thyroid nodules. Arch Dis Child 2001;85: 313-317.
  • 19. Erdoğan G, Erdoğan MF, Delange F, Sav H, Güllü S, Kamel N. Moderate to severe iodine deficiency in three endemic goitre areas from the Black Sea region and the capital of Turkey. Eur J Epidemiol 2000;16:1131-1134.
  • 20. Erdoğan MF, Demır O, Emral R, Kamel AN, Erdoğan G. More than a decade of iodine prophylaxis is needed to eradicate goiter among school age children in a moderately iodine-deficient region. Thyroid. 2009;19: 265-268.
There are 20 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research
Authors

Zuhal Aşık 0000-0003-3062-6066

Hakan Aylanç 0000-0002-8907-3809

Publication Date December 28, 2017
Submission Date August 10, 2017
Acceptance Date December 13, 2017
Published in Issue Year 2017 Volume: 2 Issue: 3

Cite

APA Aşık, Z., & Aylanç, H. (2017). The prevalence of thyroid nodules in children with family history for nodular goiter. Family Practice and Palliative Care, 2(3), 16-21. https://doi.org/10.22391/fppc.333879
AMA Aşık Z, Aylanç H. The prevalence of thyroid nodules in children with family history for nodular goiter. Fam Pract Palliat Care. December 2017;2(3):16-21. doi:10.22391/fppc.333879
Chicago Aşık, Zuhal, and Hakan Aylanç. “The Prevalence of Thyroid Nodules in Children With Family History for Nodular Goiter”. Family Practice and Palliative Care 2, no. 3 (December 2017): 16-21. https://doi.org/10.22391/fppc.333879.
EndNote Aşık Z, Aylanç H (December 1, 2017) The prevalence of thyroid nodules in children with family history for nodular goiter. Family Practice and Palliative Care 2 3 16–21.
IEEE Z. Aşık and H. Aylanç, “The prevalence of thyroid nodules in children with family history for nodular goiter”, Fam Pract Palliat Care, vol. 2, no. 3, pp. 16–21, 2017, doi: 10.22391/fppc.333879.
ISNAD Aşık, Zuhal - Aylanç, Hakan. “The Prevalence of Thyroid Nodules in Children With Family History for Nodular Goiter”. Family Practice and Palliative Care 2/3 (December2017), 16-21. https://doi.org/10.22391/fppc.333879.
JAMA Aşık Z, Aylanç H. The prevalence of thyroid nodules in children with family history for nodular goiter. Fam Pract Palliat Care. 2017;2:16–21.
MLA Aşık, Zuhal and Hakan Aylanç. “The Prevalence of Thyroid Nodules in Children With Family History for Nodular Goiter”. Family Practice and Palliative Care, vol. 2, no. 3, 2017, pp. 16-21, doi:10.22391/fppc.333879.
Vancouver Aşık Z, Aylanç H. The prevalence of thyroid nodules in children with family history for nodular goiter. Fam Pract Palliat Care. 2017;2(3):16-21.
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Family Practice and Palliative Care       ISSN 2458-8865       E-ISSN 2459-1505