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Research Article
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Gebe sıçanlarda kantaron otunun fetüse etkisi

Year 2018, Volume: 3 Issue: 2, 85 - 91, 30.08.2018

Basak Buyuk , Mehmet Yuncu , Ayhan Eralp Serap Inaloz Demir

https://doi.org/10.22391/fppc.406844

Abstract

Giriş: Fetüste
gelişebilecek toksik ve teratolojik yan etkilerinden dolayı, gebelikte görülen
depresyonun tedavisinde kullanılabilecek ilaç sayısı oldukça sınırlıdır.
Çalışmamızda, gebelik sırasında depresyon tedavisi için halk arasında sık
kullanılan kantaron otunun fetüs karaciğeri üzerine yan etkilerini araştırdık.

Yöntem: Çalışmada kullanılan 13 adet dişi Wistar albino sıçan, 8 adet deney
grubu,  5 adet de kontrol grubu olmak
üzere ayrıldı. Gebe kalmaları sağlanan deney grubundaki hayvanlara, gebeliğin
ilk gününden itibaren, gebelik süresince 100 mg/kg/gün kantaron otu ekstresi
orogastrik sonda yardımıyla verildi. Kontrol grubundaki sıçanlara ise gebeliğin
ilk gününden itibaren her gün 2 ml distile su orogastrik sonda yardımıyla
verildi. Doğan yavruların karaciğer dokuları çıkarıldı, %10 nötral formalin ile
fiksasyonu yapıldı, alkol takibinden sonra parafin blokları hazırlandı, alınan
kesitler hematoksilen ve eosin ile boyanarak incelendi.

Bulgular: Deney grubuna ait karaciğer dokularının histopatolojik
değerlendirmesinde mikroveziküler yağlanma ve hidropik dejenerasyon gözlendi.







Sonuç: Kantaron
otunun gebe kadınlar veya fetus açısından güvenilir olduğunu iddia etmek için
yeterli bilgi bulunmadığı sonucuna varıldı. Bu otun gebelik kullanımıyla ilgili
sakıncaların hekimler tarafından değerlendirilmesi ve özellikle birinci
basamakta hekimlerin, gebe takiplerinde hastaları bu konuda bilinçlendirmesi
önem arz etmektedir. Kantaron otunun gebelikte kullanımı ve gerek anne gerek
fetüste tüm vücuttaki etkilerinin ortaya konması için daha ileri çalışmalar
yapılması gerekmektedir.

Keywords

Kantaron otu fetüs karaciğer

References

  • Dugoua JJ, Mills E, Perri D, et al. Safety and efficacy of St. John’s Wort (hypericum) during pregnancy and lactation. Can J Clin Pharmacol 2006; 13(3):268-276. PMID: 17085775
  • Hışıl Y, Şahin F, Omay S B. Composition of Hypericum perforatum L. and its medical importance. UHOD 2005; 15:212-21
  • Di Carlo G, Borrelli F, Ernst E, et al. St John's Wort: Prozac from the plant kingdom. Trends Pharmacol Sci 2001; 22(6):292-297. doi: https://doi.org/10.1016/S0165-6147(00)01716-8
  • Kolding L, Pedersen L H, Henriksen T B, et al. Hypericum perforatum use during pregnancy and pregnancy outcome. Reprod Toxicol 2015; 58:234-237. doi: https://doi.org/10.1016/j.reprotox.2015.10.003
  • Henderson L, Yue Q Y, Bergquist C, et al. St John's Wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol 2002; 54(4):349-356. doi: https://doi.org/10.1046/j.1365-2125.2002.01683.x
  • Mennini T, Gobbi M. The antidepressant mechanism of Hypericum perforatum. Life Sci J 2004; 75(9):1021-1027. doi: https://doi.org/10.1016/j.lfs.2004.04.005
  • Çelik S, Konkan R, Erkmen H, et al. [Herbal medicine and its use in psychiatry]. Düşünen Adam 2007; 20:186-95.
  • Erdem S, Eren P A. [Herbs used for therapeutic purposes and the side effects of herbal products]. Türk Hijyen ve Deneysel Biyoloji Dergisi 2009;133.
  • Dugoua J J, Mills E, Perri D, et al. Safety and efficacy of St. John’s Wort (hypericum) during pregnancy and lactation. Can J Clin Pharmacol 2006; 13(3):e268-76. PMID: 17085775
  • Harrer G, Schulz V. Clinical investigation of the antidepressant effectiveness of Hypericum. J Geria Psychiatry Neurol 1994; 7(1_suppl):6-8. doi: https://doi.org/10.1177/089198879400701s03
  • Sağduyu A, Ögel K, Özmen E, et al. [Depression in primary care]. Türk Psikiyatri Dergisi 2000; 11(1):3-16.
  • Muzik M, Marcus S M, Heringhausen J E, et al. When depression complicates childbearing: guidelines for screening and treatment during antenatal and postpartum obstetric care. Obstet Gynecol Clin North Am 2009; 36(4):771-788. doi: https://doi.org/10.1016/j.ogc.2009.10.006
  • Stewart D E. Depression during pregnancy. N Eng J Med 2011; 365(17):1605-1611. doi: https://doi.org/10.1056/NEJMcp1102730
  • Akbaş E., Vırıt O, Savaş A H, et al. [The relationship of sociodemographic variables on the anxiety and depression during pregnancy]. Arch Neuropsychiatry/Noropsikiatri Arsivi 2008; 45(3).
  • Marakoğlu K, Şahsıvar M Ş. [Depression in pregnancy]. Turkiye Klinikleri J Med Sci 2008; 28(4):525-532.
  • Doğan Ö, Avcı A. [Herbal therapy and drug interactions]. Turkiye Klinikleri Journal of Public Health-Special Topic 2018; 4(1):49-54.
  • Vieira M L, Hamada R Y, Gonzaga N I, et al. Could maternal exposure to the antidepressants fluoxetine and St. John's Wort induce long-term reproductive effects on male rats? Reprod Toxicol 2013; 35:102-107. doi: https://doi.org/10.1016/j.reprotox.2012.07.006
  • Moretti M E.-, Maxson A, Hanna F, et al. Evaluating the safety of St. John's Wort in human pregnancy. Reprod Toxicol 2009; 28(1):96-99. doi: https://doi.org/10.1016/j.reprotox.2009.02.003
  • Grush L R, Nierenberg A, Keefe B, et al. St John's wort during pregnancy. JAMA 1998; 280(18):1566-1566. doi: https://doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-280-18-jbk1111
  • Chan L Y S, Chiu P Y, Lau T K. A study of hypericin-induced teratogenicity during organogenesis using a whole rat embryo culture model. Fertil steril 2001; 76(5):1073-1074. doi: https://doi.org/10.1016/S0015-0282(01)02730-3
  • Cada A M, Hansen D K, LaBorde J B, et al. Minimal effects from developmental exposure to St. John's wort (Hypericum perforatum) in Sprague-Dawley rats. Nutr Neurosci 2001; 4(2):135-141. doi: https://doi.org/10.1080/1028415X.2001.11747357
  • Rayburn W F, Christensen H D, Gonzalez C L. Effect of antenatal exposure to Saint John’s wort (Hypericum) on neurobehavior of developing mice. Am J Obstet Gynecol 2000; 183(5):1225-1231. doi: https://doi.org/10.1067/mob.2000.108889
  • Rayburn W F, Gonzalez C L, Christensen H D, et al. Impact of hypericum (St.-John's-wort) given prenatally on cognition of mice offspring. Neurotoxicol teratol 2001; 23(6):629-637. doi: https://doi.org/10.1016/S0892-0362(01)00179-9
  • Rayburn W F, Gonzalez C L, Christensen H D, et al. Effect of prenatally administered hypericum (St John’s wort) on growth and physical maturation of mouse offspring. Am J Obstet Gynecol 2001; 184(2):191-195. doi: https://doi.org/10.1067/mob.2001.108339
  • Gregoretti B, Stebel M, Candussio L, et al. Toxicity of Hypericum perforatum (St. John's wort) administered during pregnancy and lactation in rats. Toxicol Appl Pharmacol 2004; 200(3):201-205. doi: https://doi.org/10.1016/j.taap.2004.04.020
  • Borges L V, do Carmo Cancino J C, Peters V M, et al. Development of pregnancy in rats treated with Hypericum perforatum. Phytother Res 2005; 19(10):885-887. doi: https://doi.org/10.1002/ptr.1748

Effects of Saint John’s wort on the fetus in pregnant rats

Year 2018, Volume: 3 Issue: 2, 85 - 91, 30.08.2018

Basak Buyuk , Mehmet Yuncu , Ayhan Eralp Serap Inaloz Demir

https://doi.org/10.22391/fppc.406844

Abstract

Introduction: Because of the toxic and teratologic side effects that might develop
into the fetus, the number of drugs that can be used in the treatment of
depression seen in pregnancy is very limited. In this study, we investigated
whether the Saint John’s wort used during pregnancy has side effects on the
liver of fetus.

Methods: Thirteen Wistar albino female rats were used in this study. The animals
divided into two groups as 8 rats for the experimental group and 5 rats for the
control group.  The animals detected for
pregnancy in the experimental group were fed with the Saint John’s wort extract
as 100 mg/kg/day through orogastric probe from the first day of the pregnancy.
The animals in the control group were fed with 2 ml distiled water through an
orogastric probe every day begining from the first day of the pregnancy. The
newborn pups were taken. Their liver tissues were harvested and investigated after
the tissue processing and staining procedure.

Results: Microvesicular lipidosis and hydropic degeneration were observed in
histopathological evaluation of the harvested tissues of experimental group.







Conclusion: As a result, there is not enough data in the literature in order to
claim that Saint John’s worth is reliable for the pregnant women or fetus. It
is important for the physician to evaluate the complaints related to the use of
pregnancy and to raise the awareness of the physicians in the first stage of
the pregnancy follow-up. For the usage of this herb as an alternative or
addition to antidepressive drugs more preclinical (basic) and clinical studies
need to be performed.

Keywords

Saint John’s wort fetus liver

References

  • Dugoua JJ, Mills E, Perri D, et al. Safety and efficacy of St. John’s Wort (hypericum) during pregnancy and lactation. Can J Clin Pharmacol 2006; 13(3):268-276. PMID: 17085775
  • Hışıl Y, Şahin F, Omay S B. Composition of Hypericum perforatum L. and its medical importance. UHOD 2005; 15:212-21
  • Di Carlo G, Borrelli F, Ernst E, et al. St John's Wort: Prozac from the plant kingdom. Trends Pharmacol Sci 2001; 22(6):292-297. doi: https://doi.org/10.1016/S0165-6147(00)01716-8
  • Kolding L, Pedersen L H, Henriksen T B, et al. Hypericum perforatum use during pregnancy and pregnancy outcome. Reprod Toxicol 2015; 58:234-237. doi: https://doi.org/10.1016/j.reprotox.2015.10.003
  • Henderson L, Yue Q Y, Bergquist C, et al. St John's Wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol 2002; 54(4):349-356. doi: https://doi.org/10.1046/j.1365-2125.2002.01683.x
  • Mennini T, Gobbi M. The antidepressant mechanism of Hypericum perforatum. Life Sci J 2004; 75(9):1021-1027. doi: https://doi.org/10.1016/j.lfs.2004.04.005
  • Çelik S, Konkan R, Erkmen H, et al. [Herbal medicine and its use in psychiatry]. Düşünen Adam 2007; 20:186-95.
  • Erdem S, Eren P A. [Herbs used for therapeutic purposes and the side effects of herbal products]. Türk Hijyen ve Deneysel Biyoloji Dergisi 2009;133.
  • Dugoua J J, Mills E, Perri D, et al. Safety and efficacy of St. John’s Wort (hypericum) during pregnancy and lactation. Can J Clin Pharmacol 2006; 13(3):e268-76. PMID: 17085775
  • Harrer G, Schulz V. Clinical investigation of the antidepressant effectiveness of Hypericum. J Geria Psychiatry Neurol 1994; 7(1_suppl):6-8. doi: https://doi.org/10.1177/089198879400701s03
  • Sağduyu A, Ögel K, Özmen E, et al. [Depression in primary care]. Türk Psikiyatri Dergisi 2000; 11(1):3-16.
  • Muzik M, Marcus S M, Heringhausen J E, et al. When depression complicates childbearing: guidelines for screening and treatment during antenatal and postpartum obstetric care. Obstet Gynecol Clin North Am 2009; 36(4):771-788. doi: https://doi.org/10.1016/j.ogc.2009.10.006
  • Stewart D E. Depression during pregnancy. N Eng J Med 2011; 365(17):1605-1611. doi: https://doi.org/10.1056/NEJMcp1102730
  • Akbaş E., Vırıt O, Savaş A H, et al. [The relationship of sociodemographic variables on the anxiety and depression during pregnancy]. Arch Neuropsychiatry/Noropsikiatri Arsivi 2008; 45(3).
  • Marakoğlu K, Şahsıvar M Ş. [Depression in pregnancy]. Turkiye Klinikleri J Med Sci 2008; 28(4):525-532.
  • Doğan Ö, Avcı A. [Herbal therapy and drug interactions]. Turkiye Klinikleri Journal of Public Health-Special Topic 2018; 4(1):49-54.
  • Vieira M L, Hamada R Y, Gonzaga N I, et al. Could maternal exposure to the antidepressants fluoxetine and St. John's Wort induce long-term reproductive effects on male rats? Reprod Toxicol 2013; 35:102-107. doi: https://doi.org/10.1016/j.reprotox.2012.07.006
  • Moretti M E.-, Maxson A, Hanna F, et al. Evaluating the safety of St. John's Wort in human pregnancy. Reprod Toxicol 2009; 28(1):96-99. doi: https://doi.org/10.1016/j.reprotox.2009.02.003
  • Grush L R, Nierenberg A, Keefe B, et al. St John's wort during pregnancy. JAMA 1998; 280(18):1566-1566. doi: https://doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-280-18-jbk1111
  • Chan L Y S, Chiu P Y, Lau T K. A study of hypericin-induced teratogenicity during organogenesis using a whole rat embryo culture model. Fertil steril 2001; 76(5):1073-1074. doi: https://doi.org/10.1016/S0015-0282(01)02730-3
  • Cada A M, Hansen D K, LaBorde J B, et al. Minimal effects from developmental exposure to St. John's wort (Hypericum perforatum) in Sprague-Dawley rats. Nutr Neurosci 2001; 4(2):135-141. doi: https://doi.org/10.1080/1028415X.2001.11747357
  • Rayburn W F, Christensen H D, Gonzalez C L. Effect of antenatal exposure to Saint John’s wort (Hypericum) on neurobehavior of developing mice. Am J Obstet Gynecol 2000; 183(5):1225-1231. doi: https://doi.org/10.1067/mob.2000.108889
  • Rayburn W F, Gonzalez C L, Christensen H D, et al. Impact of hypericum (St.-John's-wort) given prenatally on cognition of mice offspring. Neurotoxicol teratol 2001; 23(6):629-637. doi: https://doi.org/10.1016/S0892-0362(01)00179-9
  • Rayburn W F, Gonzalez C L, Christensen H D, et al. Effect of prenatally administered hypericum (St John’s wort) on growth and physical maturation of mouse offspring. Am J Obstet Gynecol 2001; 184(2):191-195. doi: https://doi.org/10.1067/mob.2001.108339
  • Gregoretti B, Stebel M, Candussio L, et al. Toxicity of Hypericum perforatum (St. John's wort) administered during pregnancy and lactation in rats. Toxicol Appl Pharmacol 2004; 200(3):201-205. doi: https://doi.org/10.1016/j.taap.2004.04.020
  • Borges L V, do Carmo Cancino J C, Peters V M, et al. Development of pregnancy in rats treated with Hypericum perforatum. Phytother Res 2005; 19(10):885-887. doi: https://doi.org/10.1002/ptr.1748
There are 26 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research
Authors

Basak Buyuk 0000-0003-1817-2241

Mehmet Yuncu 0000-0002-2519-6834

Ayhan Eralp 0000-0002-0224-6173

Serap Inaloz Demir 0000-0001-9684-255X

Publication Date August 30, 2018
Submission Date March 16, 2018
Acceptance Date June 26, 2018
Published in Issue Year 2018 Volume: 3 Issue: 2

Cite

APA Buyuk, B., Yuncu, M., Eralp, A., Inaloz Demir, S. (2018). Effects of Saint John’s wort on the fetus in pregnant rats. Family Practice and Palliative Care, 3(2), 85-91. https://doi.org/10.22391/fppc.406844
AMA Buyuk B, Yuncu M, Eralp A, Inaloz Demir S. Effects of Saint John’s wort on the fetus in pregnant rats. Fam Pract Palliat Care. August 2018;3(2):85-91. doi:10.22391/fppc.406844
Chicago Buyuk, Basak, Mehmet Yuncu, Ayhan Eralp, and Serap Inaloz Demir. “Effects of Saint John’s Wort on the Fetus in Pregnant Rats”. Family Practice and Palliative Care 3, no. 2 (August 2018): 85-91. https://doi.org/10.22391/fppc.406844.
EndNote Buyuk B, Yuncu M, Eralp A, Inaloz Demir S (August 1, 2018) Effects of Saint John’s wort on the fetus in pregnant rats. Family Practice and Palliative Care 3 2 85–91.
IEEE B. Buyuk, M. Yuncu, A. Eralp, and S. Inaloz Demir, “Effects of Saint John’s wort on the fetus in pregnant rats”, Fam Pract Palliat Care, vol. 3, no. 2, pp. 85–91, 2018, doi: 10.22391/fppc.406844.
ISNAD Buyuk, Basak et al. “Effects of Saint John’s Wort on the Fetus in Pregnant Rats”. Family Practice and Palliative Care 3/2 (August2018), 85-91. https://doi.org/10.22391/fppc.406844.
JAMA Buyuk B, Yuncu M, Eralp A, Inaloz Demir S. Effects of Saint John’s wort on the fetus in pregnant rats. Fam Pract Palliat Care. 2018;3:85–91.
MLA Buyuk, Basak et al. “Effects of Saint John’s Wort on the Fetus in Pregnant Rats”. Family Practice and Palliative Care, vol. 3, no. 2, 2018, pp. 85-91, doi:10.22391/fppc.406844.
Vancouver Buyuk B, Yuncu M, Eralp A, Inaloz Demir S. Effects of Saint John’s wort on the fetus in pregnant rats. Fam Pract Palliat Care. 2018;3(2):85-91.
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Family Practice and Palliative Care       ISSN 2458-8865       E-ISSN 2459-1505