Year 2019, Volume 4 , Issue 2, Pages 57 - 61 2019-08-30

Febrile seizures: is there a significance of chronological ranking of fever and seizure?
Febril nöbetler: Ateş sonrası nöbet zamansal sıralamasının bir önemi var mıdır?

Turgay Cokyaman [1]


Introduction:Seizures observed in febrile disease periods in healthy children aged from 3 months to 6 years are known as febrile seizures (FS). There is usually a chronological sequence involving seizure following fever in most FS, but some cases may not follow this pattern. This study investigated the chronological relation between fever and convulsion and whether clinical and laboratory findings affect this.

Methods:Patients with FS between 1 December, 2015, and 1 April, 2016, were included in this study. Cases with a regular fever plus seizure chronological sequence were classified as classical FS. Without a regular chronological sequence, fever after seizure, were classified as non-classical FS. The effect on both groups of parameters such as gender, age, height, weight, type of FS (simple or complex), previous history of FS, family history of FS, family history of epilepsy, qualitative c-reactive protein (CRP) and white blood cell (WBC) count were evaluated.

Results:Twenty-seven percent of FS were non-classical and 73% were classical. Negative CRP and low WBC emerged as significant predictors of non-classical FS at binary logistic regression (OR=1.388, 95% CI 1.051-1.834 and OR=9.021, 95% CI 1.298-62.702, respectively). Other factors such as gender, age, height, weight, type of FS, previous history of FS, familyhistory of FS, familyhistory of epilepsyhad no effect in terms of nonclassic FS.

Conclusions:Acute inflammatory response findings such as increased CRP, WBC and fever may not accompany in non-classical FS. Although the diagnosis of FS is correct in such cases, misunderstandings may occur between the physician and parents because of the nomenclature employed.

Giriş: 3 ay-6 yaş arası sağlıklı çocuklarda ateşli hastalık dönemlerinde görülen nöbetlere febril nöbetler (FN)denilmektedir. FN’lerin çoğunda ateş sonrası nöbet zamansal sıralaması görülmekte iken bazı vakalarda bu durum görülmemektedir. Bu çalışmada FN’li hastalarda ateş ve nöbetin zamansal sıralaması ve klinik ve laboratuar bulguların bu zamansal sıralamaya etkilerinin olup olmadığı araştırılmıştır.

Yöntem: 1 Aralık 2015 ve 1 Nisan 2016 tarihleri arasında FN tanısı alan hastalar çalışmaya alındı. Ateş sonrası nöbet zamansal sıralaması gösteren vakalar klasik FN olarak sınıflandırıldı. Ateş sonrası nöbet zamansal sıralaması göstermeyen vakalar ise klasik olmayan FN olarak sınıflandırıldı. Cinsiyet, yaş, boy, vücut ağırlığı, febril nöbet tipi (basit, kompleks), daha önce geçirilmiş FN hikayesi varlığı, ailede FN hikayesi olması, ailede epilepsi varlığı, kalitatif C-reaktif protein (CRP) ve beyaz kan hücre (WBC) sayısından oluşan kategorik ve sayısal değişkenlerinin klasik ve klasik olmayan FN’lere etkisi değerlendirildi.

Bulgular: Hastaların %73’ü klasik, %27’si ise klasik olmayan FN tanısı aldı. Gruplar arası karşılaştırmalarda yalnız WBC sayısı farklı bulundu ve klasik olmayan FN grubunda anlamlı düzeyde düşüktü. İkili lojistik regresyon analizi sonucu negatif kalitatif CRP ve düşük WBC sayısının klasik olmayan FN’ler için anlamlı prediktörler olduğu ortaya çıktı (sırasıyla OR=1,388; 95%CI 1,051-1,834 ve OR=9,021; 95%CI 1,298-62,702).     

Sonuç: Klasik olmayan FN’lerde ateş, pozitif CRP yanıtı ve WBC sayısı artışı gibi akut inflamatuar yanıtın göstergeleri görülmeyebilir. Bu tarz vakalarda FN tanısı doğru olsa da tıbbi isimlendirmeden kaynaklanan hekim ve ebeveyn iletişim sorunları doğabilmektedir. 

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Primary Language en
Subjects Health Care Sciences and Services
Published Date Aug 2019
Journal Section Original Research
Authors

Orcid: 0000-0002-7108-6839
Author: Turgay Cokyaman (Primary Author)
Institution: Cengiz Gokcek Maternity and Children’s Hospital, Department of Pediatrics, Division of Pediatric Neurology, Gaziantep
Country: Turkey


Dates

Publication Date : August 30, 2019

Bibtex @research article { fppc491220, journal = {Family Practice and Palliative Care}, issn = {2458-8865}, eissn = {2459-1505}, address = {}, publisher = {SERNEV}, year = {2019}, volume = {4}, pages = {57 - 61}, doi = {10.22391/fppc.491220}, title = {Febrile seizures: is there a significance of chronological ranking of fever and seizure?}, key = {cite}, author = {Cokyaman, Turgay} }
APA Cokyaman, T . (2019). Febrile seizures: is there a significance of chronological ranking of fever and seizure?. Family Practice and Palliative Care , 4 (2) , 57-61 . DOI: 10.22391/fppc.491220
MLA Cokyaman, T . "Febrile seizures: is there a significance of chronological ranking of fever and seizure?". Family Practice and Palliative Care 4 (2019 ): 57-61 <http://www.fppc.com.tr/en/issue/48029/491220>
Chicago Cokyaman, T . "Febrile seizures: is there a significance of chronological ranking of fever and seizure?". Family Practice and Palliative Care 4 (2019 ): 57-61
RIS TY - JOUR T1 - Febrile seizures: is there a significance of chronological ranking of fever and seizure? AU - Turgay Cokyaman Y1 - 2019 PY - 2019 N1 - doi: 10.22391/fppc.491220 DO - 10.22391/fppc.491220 T2 - Family Practice and Palliative Care JF - Journal JO - JOR SP - 57 EP - 61 VL - 4 IS - 2 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.491220 UR - https://doi.org/10.22391/fppc.491220 Y2 - 2019 ER -
EndNote %0 Family Practice and Palliative Care Febrile seizures: is there a significance of chronological ranking of fever and seizure? %A Turgay Cokyaman %T Febrile seizures: is there a significance of chronological ranking of fever and seizure? %D 2019 %J Family Practice and Palliative Care %P 2458-8865-2459-1505 %V 4 %N 2 %R doi: 10.22391/fppc.491220 %U 10.22391/fppc.491220
ISNAD Cokyaman, Turgay . "Febrile seizures: is there a significance of chronological ranking of fever and seizure?". Family Practice and Palliative Care 4 / 2 (August 2019): 57-61 . https://doi.org/10.22391/fppc.491220
AMA Cokyaman T . Febrile seizures: is there a significance of chronological ranking of fever and seizure?. Fam Pract Palliat Care. 2019; 4(2): 57-61.
Vancouver Cokyaman T . Febrile seizures: is there a significance of chronological ranking of fever and seizure?. Family Practice and Palliative Care. 2019; 4(2): 61-57.