Year 2019, Volume 4 , Issue 3, Pages 85 - 88 2019-12-31

İnsidental tiroid papiller karsinomda enflamatuar hücre oranlarının prediktif değeri
Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma

Huseyin Avni EROGLU [1] , Sunay Sibel KARAYOL [2] , Bulent GUVENDİ [3] , Yasemen ADALİ [4]


Giriş: İnflamatuvar süreçlerin karsinogenetik süreçler ile ilişkisi bilinmekte ve sistemik inflamatuvar belirteçlerin tanısal ve prognostik değeri araştırılmaktadır. Bu çalışmada insidental olarak saptanan tiroid papiller karsinomlarda tam kan sayımından elde edilen inflamatuvar hücre verilerinin prediktif değerini araştırmak amaçlanmıştır.

Yöntem: Histopatolojik tanıları multinodüler hiperplazi (MNH) (n=20), lenfositik tiroidit (LT) (n=20), insidental tiroid papiller karsinom (İTPK) (n=20), insidental papiller karsinom ve lenfositik tiroidit (İTPKLT) (n=20) ve tiroid papiller karsinom (TPK) (n=20) olmak üzere toplam 100 olgu çalışmaya dahil edildi. Olguların nötrofil/ lenfosit oranı (NLO), platelet lenfosit oranı (PLO), platelet/ nötrofil oranı (PNO), lenfosit monosit oranı (LMO) ve lenfosit eozinofil oranı (LEO) değerleri gruplar arasında karşılaştırıldı.

Bulgular: İnflamatuvar hücre ortalamaları ve platelet verileri incelendiğinde gruplar arasında bariz farklılık dikkati çekmedi.  İnsidental tiroid papiller karsinom ile yapılan analizlerde İTPKLT grubu ile arasında LMO ve LEO açısından belirgin istatistiksel anlamlılık gözlendi (p değerleri sırası ile 0,009 ve 0,037). Buna göre LMO İTPK'da yüksek, LEO ise İTPKLT grubunda yüksek saptandı.

Sonuç: İnflamatuvar hücrelere dair karsinogenetik süreçlerde salt sistemik inflamatuvar belirteçler olarak kullanılan NLR, PLR gibi oranların değil LEO ve LMO gibi oranlarında değerlendirilmesinin gelecekte önem arz edebileceğini ve bu nedenle özellikle inflamatuvar süreçlerin etyolojide yer aldığı tümörlerde geniş olgu serilerinde incelenmesi gerektiğini düşünmekteyiz. 

Introduction: Due to the well-known relationship between inflammatory processes and carcinogenesis, the diagnostic and prognostic value of systemic inflammatory markers are at the focus of research. This study aimed to investigate the predictive value of inflammatory cell data obtained from complete blood count in incidentally detected thyroid papillary carcinoma.

Methods: A total of 100 cases were included in the study, consisting of histopathologically diagnosed multinodular hyperplasia (MNH) (N = 20), lymphocytic thyroiditis (LT) (n = 20), incidental thyroid papillary carcinoma (ITPC) (n = 20), incidental papillary carcinoma and lymphocytic thyroiditis (ITPCLT) (n = 20), and thyroid papillary carcinoma (TPC) (n = 20). Neutrophil / lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), platelet/neutrophil ratio (PNR), lymphocyte/ monocyte ratio (LMR) and lymphocyte/ eosinophil ratio (LER) values were compared between the groups.

Results: No significant difference was detected between the groups concerning the mean inflammatory cell and platelet values. However, statistical significance was observed between the ITPC and ITPCLT groups regarding the mean LMR and LER values (p=0.009 and p=0.037, respectively). Higher LMR was found in the ITPC group, while higher LER was seen in the ITPCLT group.

Conclusions: We suggest that besides ratios such as NLR and PLR used as systemic inflammatory markers in carcinogenetic processes, the evaluation of LER and LMR might be imperative as well. Therefore, these potential markers should be studied in bigger series of tumors, especially where inflammatory processes are involved in the etiology.

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Primary Language en
Subjects Medicine
Published Date Dec 2019
Journal Section Original Research
Authors

Orcid: 0000-0002-1040-3255
Author: Huseyin Avni EROGLU
Institution: Department of Physiology, Canakkale Onsekiz Mart University, Canakkale
Country: Turkey


Orcid: 0000-0002-2696-3580
Author: Sunay Sibel KARAYOL
Institution: Department of Radiology, Harran University, Sanliurfa
Country: Turkey


Orcid: 0000-0002-0930-0443
Author: Bulent GUVENDİ
Institution: Department of General Surgery, Recep Tayyip Erdogan University, Rize
Country: Turkey


Orcid: 0000-0002-8004-7364
Author: Yasemen ADALİ (Primary Author)
Institution: Department of Pathology, Canakkale Onsekiz Mart University, Canakkale
Country: Turkey


Thanks We thank Dr. Tugba Toyran for helping in data collection.
Dates

Application Date : January 26, 2019
Acceptance Date : July 14, 2019
Publication Date : December 31, 2019

Bibtex @research article { fppc518251, journal = {Family Practice and Palliative Care}, issn = {2458-8865}, eissn = {2459-1505}, address = {}, publisher = {SERNEV}, year = {2019}, volume = {4}, pages = {85 - 88}, doi = {10.22391/fppc.518251}, title = {Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma}, key = {cite}, author = {EROGLU, Huseyin Avni and KARAYOL, Sunay Sibel and GUVENDİ, Bulent and ADALİ, Yasemen} }
APA EROGLU, H , KARAYOL, S , GUVENDİ, B , ADALİ, Y . (2019). Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma. Family Practice and Palliative Care , 4 (3) , 85-88 . DOI: 10.22391/fppc.518251
MLA EROGLU, H , KARAYOL, S , GUVENDİ, B , ADALİ, Y . "Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma". Family Practice and Palliative Care 4 (2019 ): 85-88 <http://www.fppc.com.tr/en/issue/50274/518251>
Chicago EROGLU, H , KARAYOL, S , GUVENDİ, B , ADALİ, Y . "Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma". Family Practice and Palliative Care 4 (2019 ): 85-88
RIS TY - JOUR T1 - Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma AU - Huseyin Avni EROGLU , Sunay Sibel KARAYOL , Bulent GUVENDİ , Yasemen ADALİ Y1 - 2019 PY - 2019 N1 - doi: 10.22391/fppc.518251 DO - 10.22391/fppc.518251 T2 - Family Practice and Palliative Care JF - Journal JO - JOR SP - 85 EP - 88 VL - 4 IS - 3 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.518251 UR - https://doi.org/10.22391/fppc.518251 Y2 - 2019 ER -
EndNote %0 Family Practice and Palliative Care Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma %A Huseyin Avni EROGLU , Sunay Sibel KARAYOL , Bulent GUVENDİ , Yasemen ADALİ %T Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma %D 2019 %J Family Practice and Palliative Care %P 2458-8865-2459-1505 %V 4 %N 3 %R doi: 10.22391/fppc.518251 %U 10.22391/fppc.518251
ISNAD EROGLU, Huseyin Avni , KARAYOL, Sunay Sibel , GUVENDİ, Bulent , ADALİ, Yasemen . "Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma". Family Practice and Palliative Care 4 / 3 (December 2020): 85-88 . https://doi.org/10.22391/fppc.518251
AMA EROGLU H , KARAYOL S , GUVENDİ B , ADALİ Y . Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma. Fam Pract Palliat Care. 2019; 4(3): 85-88.
Vancouver EROGLU H , KARAYOL S , GUVENDİ B , ADALİ Y . Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma. Family Practice and Palliative Care. 2019; 4(3): 88-85.