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Evaluation of children with acute gastroenteritis in Konya region

Year 2021, Volume: 6 Issue: 1, 1 - 6, 31.03.2021

Ahmet Osman Kılıç , Hussein M.h. Atwan , Abdullah Yazar , Fatih Akın

https://doi.org/10.22391/fppc.762330
Cited By: 1

Abstract

Introduction: Acute gastroenteritis is a major cause of pediatric morbidity and mortality around the world. It remains a frequent reason for infection-related admissions to emergency units among all age groups. Epidemiologic knowledge about etiology of gastroenteritis in a certain area allows early and correct diagnosis. The current study aimed at evaluating the prevalence of bacterial, viral, and parasitic pathogens in children with gastroenteritis who admitted to pediatric emergency unit.
Methods: The demographic, clinical and laboratory data of 450 children with acute gastroenteritis, within the age range of 0 months to 18 years who admitted to Pediatric Emergency Department of Meram Faculty of Medicine from September 2018 to September 2019 were retrospectively analyzed.
Results: While 31.10% of the patients had etiological agents, 68.90% of the patients could not be identified. The identified pathogens were 2.10% bacteria, 82.20% virus, 15.70% parasite. The most common pathogen was Rotavirus with a rate of 72.90%. This was followed by E. histolytica with 15.00% and Adenovirus with 9.30%. Rotavirus was most frequently detected at the age of 2 years, and E. histolytica was most frequently detected at the age of 5 years. Rotavirus was most common in the winter season [33.7%]. 7.10% of the patients were hospitalized. The average length of hospital stay was 3.34 ± 2.19 days.
Conclusion: Rotavirus, E. histolytica and Adenovirus were the most prevalent agents of diarrhea in children aged 0 month to 18 years who admitted to emergency unit in this study.

Keywords

Çocuklar Çocuk Acil Servis Gastroenterit

Project Number

yok

References

  • 1. Kotloff KL. Acute Gastroenteritis in Children. In: Kliegman RM, St. Geme III JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, editors. Nelson Textbook of Pediatrics. 21st ed. Philadelphia: Elsevier; 2020. p. 2012–32.
  • 2. Tekin M, Topaloglu N, Yildirim S, Binnetoglu K, Kaymaz N, Aylanc H, et al. Frequency of Rotavirus in children with acute gastroenteritis. Int J Clin Res. 2014;2(1):18-20.
  • 3. Gill CJ, Thea DM, Hibberd P. Diarrhoeal disease trends in the GBD 2015 study: optimism tempered by scepticism. Lancet Infect Dis. 2017;17(9):884–5. https://doi.org/10.1016/S1473-3099(17)30336-5
  • 4. Bialvaei AZ, Kafil HS, Asgharzadeh M, Aghazadeh M, Yousefi M. CTX-M extended-spectrum β-lactamase-producing Klebsiella spp, Salmonella spp, Shigella spp and Escherichia coli isolates in Iranian hospitals. Brazilian J Microbiol. 2016;47(3):706–11. https://doi.org/10.1016/j.bjm.2016.04.020
  • 5. Kail R. Child and Their Development. Campanella C, editor. Pearson; 2011.
  • 6. Karadag A, Acikgoz ZC, Avci Z, Catal F, Gocer S, Gamberzade S, et al. Childhood diarrhoea in Ankara, Turkey: Epidemiological and clinical features of rotavirus-positive versus rotavirus-negative cases. Scand J Infect Dis. 2005;37(4):269–75. https://doi.org/10.1080/00365540410020983
  • 7. Gurbuz F, Tezer H, Sayli TV. Etiologic factors and clinical findings of patients hospitalized children for acute gastroenteritis: epidemiologic study. Turkish J Pediatr Dis 2010;4(4):211–8.
  • 8. Ceyhan I, Cakir B, Cakir E, Tamkan S, Ozcay S. Pediatric acute gastroenteritis cases. [In Turkish] Medeniyet Med J 2002;634:11–2.
  • 9. Emiroglu MK Salman M. Seroprevalence and clinical feature of Rotavirus gastroenteritis among hospitalized children under five years old in Istanbul [In Turkish]. Rumi Pediatrics Congress Proceeding Booklet 2019. p. 268–75. https://irupec.com/tr/bildirikitabi.pdf
  • 10. Coffin SE, Elser J, Marchant C, Sawyer M, Pollara B, Fayorsey R, et al. Impact of acute rotavirus gastroenteritis on pediatric outpatient practices in the United States. Pediatr Infect Dis J 2006;25(7):584–9. https://doi.org/10.1097/01.inf.0000220251.27595.74
  • 11. Ghssein G, Salami A, Salloum L, Chedid P, Joumaa WH, Fakih H. Surveillance study of acute gastroenteritis etiologies in hospitalized children in South Lebanon [SAGE study]. Pediatr Gastroenterol Hepatol Nutr 2018;21(3):176–83. https://doi.org/10.5223/pghn.2018.21.3.176
  • 12. Charles MD, Holman RC, Curns AT, Parashar UD, Glass RI, Bresee JS. Hospitalizations associated with rotavirus gastroenteritis in the United States, 1993-2002. Pediatr Infect Dis J 2006;25(6):489–93. https://doi.org/10.1097/01.inf.0000215234.91997.21
  • 13. Giaquinto C. The paediatric burden of rotavirus disease in Europe. Epidemiol Infect 2006;134(5):908–16. https://doi.org/10.1017/S0950268806006091
  • 14. Brunser O, Espinoza J Brunser AM. Etiology of Diarrhea: Bacteria and parasites. Nestle Nutr Work Ser Lippincott-Raven comp 1997;(38):13–39. https://www.nestlenutrition-institute.org/resources/publication-series/publications/article/details/nniw38---diarrheal-disease/etiology-of-diarrhea-bacteria-and-parasites (Access Date: March 04, 2021)
  • 15. Friesema IHM, De Boer RF, Duizer E, Kortbeek LM, Notermans DW, Norbruis OF, et al. Etiology of acute gastroenteritis in children requiring hospitalization in the Netherlands Eur J Clin Microbiol Infect Dis 2012;31(4):405–15. https://doi.org/10.1007/s10096-011-1320-0
  • 16. Nicholson MR, Van Horn GT, Tang YW, Vinjé J, Payne DC, Edwards KM, et al. Using multiplex molecular testing to determine the etiology of acute gastroenteritis in children. J Pediatr 2016;176:50-56.e2. https://doi.org/10.1016/j.jpeds.2016.05.068
  • 17. Chen SM, Ni YH, Chen HL, Chang MH. Microbial etiology of acute gastroenteritis in hospitalized children in Taiwan. J Formos Med Assoc 2006;105(12):964–70. https://doi.org/10.1016/S0929-6646(09)60280-1
  • 18. Parashar U, Steele D, Neuzil K, Quadros C De, Tharmaphornpilas P, Serhan F, et al. Progress with rotavirus vaccines: Summary of the tenth international rotavirus symposium. Expert Rev Vaccines 2013;12(2):113–7. https://doi.org/10.1586/erv.12.148
  • 19. Berk E, Kayman T. Frequency of Rotavirus in children with acute gastroenteritis [In Turkish]. Ankem J 2012;25(2):103–6. https://doi.org/10.5222/ankem.2011.103
  • 20. Celik AY, Emiroglu M, Kurtoglu MG, Inci A, Odabas D. Investigation of the frequency of viral agents in children with acute gastroenteritis in the 0-5 years age group [In Turkish]. Turkish J Pediatr Dis 2016;(2):101–6.
  • 21. Kazi AM, Khan MMA, Zaidi AKM, Akhter R, Aziz F, Billoo AG, et al. Sentinel hospital-based surveillance for assessment of burden of rotavirus gastroenteritis in children in Pakistan. PLoS One 2014;9(10): e108221. https://doi.org/10.1371/journal.pone.0108221
  • 22. Bozdayi G, Dogan B, Dalgic B, Bostanci I, Sari S, Battaloglu NO, et al. Diversity of Human Rotavirus G9 among children in Turkey. J Med Virol 2008;(80):733–40. https://doi.org/10.1002/jmv.21120
  • 23. Kocak M, Caliskan E, Koksal AO. Rotavirus frequency in children with acute gastroenteritis who were hospitalized in Kecioren Education and Research Hospital Pediatric Clinic. [In Turkish] Ankem J 2014;28(4):134–7. https://doi.org/10.5222/ankem.2014.134
  • 24. Bulut Y, Iseri L, Agel E DB. The positivity of Rotavirus in children with suspected acute gastroenteritis. [In Turkish] J Med Faculty Inonu Univ 2003;10(3):143–5.
  • 25. Jia L, Qian Y, Zhang Y, Deng L, Liu L, Zhu R, et al. Prevalence and genetic diversity of noroviruses in outpatient pediatric clinics in Beijing, China 2010-2012. Infect Genet Evol 2014;28:71–7. https://doi.org/10.1016/j.meegid.2014.09.006
  • 26. Altındis M, Bastepe G, Ceri A, Yavru S, Kalayci R. Frequency of Rotavirus and Enteric Adenovirus infection in children with acute gastroenteritis. [In Turkish]. Med. J SDU 2008;15(2):17–20.
  • 27. Karagun BS, Gursu HA, Korkmaz O, Bozdag I, Hasbek M. A Search for the incidence of acute gastroenteritis due to Rotavirus and Enteric Adenovirus in children under five years old. J Turk Mikrobiyol Cem 2015;44(2):70–4. https://doi.org/10.5222/TMCD.2014.070
  • 28. Eroglu C. Approach to a patient with acute diarrhea. [In Turkish]. IU Cerrahpasa Faculty Med CME Act 2008;(61):171–8.
  • 29. Yapici F, Tamer GS, Arisoy ES. The Distribution of intestinal parasites and their causative factors in children. [In Turkish]. J Turkish Parasite 2008;32(4):346–50.
  • 30. Erdogan S, Yazar AS, Güven S, Durak U, Akova S. Serum transaminase elevation in patients with Rotavirus Gastroenteritis. [In Turkish] . J Clin Anal Med. 2017;8(6):488–91. https://doi.org/10.4328/JCAM.5225

Konya yöresindeki akut gastroenteritli çocukların değerlendirilmesi

Year 2021, Volume: 6 Issue: 1, 1 - 6, 31.03.2021

Ahmet Osman Kılıç , Hussein M.h. Atwan , Abdullah Yazar , Fatih Akın

https://doi.org/10.22391/fppc.762330
Cited By: 1

Abstract

Giriş:Akut gastroenterit dünya çapında çocukluk çağında morbidite ve mortalitenin önemli bir nedenidir. Tüm yaş grupları arasında acil servislere yapılan başvuruların sık görülen bir nedeni olmaya devam etmektedir. Bulunulan bölgedeki gastroenterit etkenlerinin bilinmesi, erken ve doğru tanı, etkin tedavi fırsatı sağlayacaktır. Bu çalışma Konya bölgesinde, çocuk acil servisinde gastroenterit tanısı alan çocuklarda bakteriyel, viral ve parazitik patojenlerin prevalansını değerlendirmeyi amaçlamıştır.
Yöntem: Eylül 2018-Eylül 2019 tarihleri arasında Meram Tıp Fakültesi Hastanesi Çocuk Acil Servisinde akut gastroenterit tanısı alan 0 ay ile 18 yaş arasındaki 450 akut çocuğun demografik, klinik ve laboratuvar verileri retrospektif olarak incelendi.
Bulgular: Hastaların %31,10’unda etiyolojik ajanlar bulunurken, hastaların %68,90’nda ajanlar gösterilemedi. Belirlenen patojenler 2,10'u bakteri,%82,20 virüs,%15,70 parazit idi. En sık saptanan patojen %72,90 oranı ile Rotavirus’tu. Bunu %15,00 ile E. histolytica ve %9,30 ile Adenovirus izledi. Rotavirus en sık ilk 2 yaşta, E. histolytica ise en sık 5 yaş üzerinde tespit edildi. Rotavirus en sık kış mevsiminde [%33,70] görüldü. Hastaların %7,10’u hastanede yatarak tedavi edildi. Ortalama hastanede yatış süresi 3,34 ± 2,19 gün idi.
Sonuç: Bu çalışmada Rotavirus, E. histolytica ve Adenovirus acil servise başvuran 0 ay ile 18 yaş arasındaki çocuklarda en yaygın gastroenterit etkenleridir.

Keywords

acute gastroenteritis children emergency clinic

Supporting Institution

yok

Project Number

yok

References

  • 1. Kotloff KL. Acute Gastroenteritis in Children. In: Kliegman RM, St. Geme III JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, editors. Nelson Textbook of Pediatrics. 21st ed. Philadelphia: Elsevier; 2020. p. 2012–32.
  • 2. Tekin M, Topaloglu N, Yildirim S, Binnetoglu K, Kaymaz N, Aylanc H, et al. Frequency of Rotavirus in children with acute gastroenteritis. Int J Clin Res. 2014;2(1):18-20.
  • 3. Gill CJ, Thea DM, Hibberd P. Diarrhoeal disease trends in the GBD 2015 study: optimism tempered by scepticism. Lancet Infect Dis. 2017;17(9):884–5. https://doi.org/10.1016/S1473-3099(17)30336-5
  • 4. Bialvaei AZ, Kafil HS, Asgharzadeh M, Aghazadeh M, Yousefi M. CTX-M extended-spectrum β-lactamase-producing Klebsiella spp, Salmonella spp, Shigella spp and Escherichia coli isolates in Iranian hospitals. Brazilian J Microbiol. 2016;47(3):706–11. https://doi.org/10.1016/j.bjm.2016.04.020
  • 5. Kail R. Child and Their Development. Campanella C, editor. Pearson; 2011.
  • 6. Karadag A, Acikgoz ZC, Avci Z, Catal F, Gocer S, Gamberzade S, et al. Childhood diarrhoea in Ankara, Turkey: Epidemiological and clinical features of rotavirus-positive versus rotavirus-negative cases. Scand J Infect Dis. 2005;37(4):269–75. https://doi.org/10.1080/00365540410020983
  • 7. Gurbuz F, Tezer H, Sayli TV. Etiologic factors and clinical findings of patients hospitalized children for acute gastroenteritis: epidemiologic study. Turkish J Pediatr Dis 2010;4(4):211–8.
  • 8. Ceyhan I, Cakir B, Cakir E, Tamkan S, Ozcay S. Pediatric acute gastroenteritis cases. [In Turkish] Medeniyet Med J 2002;634:11–2.
  • 9. Emiroglu MK Salman M. Seroprevalence and clinical feature of Rotavirus gastroenteritis among hospitalized children under five years old in Istanbul [In Turkish]. Rumi Pediatrics Congress Proceeding Booklet 2019. p. 268–75. https://irupec.com/tr/bildirikitabi.pdf
  • 10. Coffin SE, Elser J, Marchant C, Sawyer M, Pollara B, Fayorsey R, et al. Impact of acute rotavirus gastroenteritis on pediatric outpatient practices in the United States. Pediatr Infect Dis J 2006;25(7):584–9. https://doi.org/10.1097/01.inf.0000220251.27595.74
  • 11. Ghssein G, Salami A, Salloum L, Chedid P, Joumaa WH, Fakih H. Surveillance study of acute gastroenteritis etiologies in hospitalized children in South Lebanon [SAGE study]. Pediatr Gastroenterol Hepatol Nutr 2018;21(3):176–83. https://doi.org/10.5223/pghn.2018.21.3.176
  • 12. Charles MD, Holman RC, Curns AT, Parashar UD, Glass RI, Bresee JS. Hospitalizations associated with rotavirus gastroenteritis in the United States, 1993-2002. Pediatr Infect Dis J 2006;25(6):489–93. https://doi.org/10.1097/01.inf.0000215234.91997.21
  • 13. Giaquinto C. The paediatric burden of rotavirus disease in Europe. Epidemiol Infect 2006;134(5):908–16. https://doi.org/10.1017/S0950268806006091
  • 14. Brunser O, Espinoza J Brunser AM. Etiology of Diarrhea: Bacteria and parasites. Nestle Nutr Work Ser Lippincott-Raven comp 1997;(38):13–39. https://www.nestlenutrition-institute.org/resources/publication-series/publications/article/details/nniw38---diarrheal-disease/etiology-of-diarrhea-bacteria-and-parasites (Access Date: March 04, 2021)
  • 15. Friesema IHM, De Boer RF, Duizer E, Kortbeek LM, Notermans DW, Norbruis OF, et al. Etiology of acute gastroenteritis in children requiring hospitalization in the Netherlands Eur J Clin Microbiol Infect Dis 2012;31(4):405–15. https://doi.org/10.1007/s10096-011-1320-0
  • 16. Nicholson MR, Van Horn GT, Tang YW, Vinjé J, Payne DC, Edwards KM, et al. Using multiplex molecular testing to determine the etiology of acute gastroenteritis in children. J Pediatr 2016;176:50-56.e2. https://doi.org/10.1016/j.jpeds.2016.05.068
  • 17. Chen SM, Ni YH, Chen HL, Chang MH. Microbial etiology of acute gastroenteritis in hospitalized children in Taiwan. J Formos Med Assoc 2006;105(12):964–70. https://doi.org/10.1016/S0929-6646(09)60280-1
  • 18. Parashar U, Steele D, Neuzil K, Quadros C De, Tharmaphornpilas P, Serhan F, et al. Progress with rotavirus vaccines: Summary of the tenth international rotavirus symposium. Expert Rev Vaccines 2013;12(2):113–7. https://doi.org/10.1586/erv.12.148
  • 19. Berk E, Kayman T. Frequency of Rotavirus in children with acute gastroenteritis [In Turkish]. Ankem J 2012;25(2):103–6. https://doi.org/10.5222/ankem.2011.103
  • 20. Celik AY, Emiroglu M, Kurtoglu MG, Inci A, Odabas D. Investigation of the frequency of viral agents in children with acute gastroenteritis in the 0-5 years age group [In Turkish]. Turkish J Pediatr Dis 2016;(2):101–6.
  • 21. Kazi AM, Khan MMA, Zaidi AKM, Akhter R, Aziz F, Billoo AG, et al. Sentinel hospital-based surveillance for assessment of burden of rotavirus gastroenteritis in children in Pakistan. PLoS One 2014;9(10): e108221. https://doi.org/10.1371/journal.pone.0108221
  • 22. Bozdayi G, Dogan B, Dalgic B, Bostanci I, Sari S, Battaloglu NO, et al. Diversity of Human Rotavirus G9 among children in Turkey. J Med Virol 2008;(80):733–40. https://doi.org/10.1002/jmv.21120
  • 23. Kocak M, Caliskan E, Koksal AO. Rotavirus frequency in children with acute gastroenteritis who were hospitalized in Kecioren Education and Research Hospital Pediatric Clinic. [In Turkish] Ankem J 2014;28(4):134–7. https://doi.org/10.5222/ankem.2014.134
  • 24. Bulut Y, Iseri L, Agel E DB. The positivity of Rotavirus in children with suspected acute gastroenteritis. [In Turkish] J Med Faculty Inonu Univ 2003;10(3):143–5.
  • 25. Jia L, Qian Y, Zhang Y, Deng L, Liu L, Zhu R, et al. Prevalence and genetic diversity of noroviruses in outpatient pediatric clinics in Beijing, China 2010-2012. Infect Genet Evol 2014;28:71–7. https://doi.org/10.1016/j.meegid.2014.09.006
  • 26. Altındis M, Bastepe G, Ceri A, Yavru S, Kalayci R. Frequency of Rotavirus and Enteric Adenovirus infection in children with acute gastroenteritis. [In Turkish]. Med. J SDU 2008;15(2):17–20.
  • 27. Karagun BS, Gursu HA, Korkmaz O, Bozdag I, Hasbek M. A Search for the incidence of acute gastroenteritis due to Rotavirus and Enteric Adenovirus in children under five years old. J Turk Mikrobiyol Cem 2015;44(2):70–4. https://doi.org/10.5222/TMCD.2014.070
  • 28. Eroglu C. Approach to a patient with acute diarrhea. [In Turkish]. IU Cerrahpasa Faculty Med CME Act 2008;(61):171–8.
  • 29. Yapici F, Tamer GS, Arisoy ES. The Distribution of intestinal parasites and their causative factors in children. [In Turkish]. J Turkish Parasite 2008;32(4):346–50.
  • 30. Erdogan S, Yazar AS, Güven S, Durak U, Akova S. Serum transaminase elevation in patients with Rotavirus Gastroenteritis. [In Turkish] . J Clin Anal Med. 2017;8(6):488–91. https://doi.org/10.4328/JCAM.5225
There are 30 citations in total.

Details

Primary Language English
Subjects Paediatrics
Journal Section Original Research
Authors

Ahmet Osman Kılıç 0000-0002-3451-6764

Hussein M.h. Atwan 0000-0002-4217-0943

Abdullah Yazar 0000-0003-0733-3943

Fatih Akın 0000-0001-5725-3867

Project Number yok
Publication Date March 31, 2021
Submission Date July 2, 2020
Acceptance Date December 23, 2020
Published in Issue Year 2021 Volume: 6 Issue: 1

Cite

APA Kılıç, A. O., Atwan, H. M., Yazar, A., Akın, F. (2021). Evaluation of children with acute gastroenteritis in Konya region. Family Practice and Palliative Care, 6(1), 1-6. https://doi.org/10.22391/fppc.762330
AMA Kılıç AO, Atwan HM, Yazar A, Akın F. Evaluation of children with acute gastroenteritis in Konya region. Fam Pract Palliat Care. April 2021;6(1):1-6. doi:10.22391/fppc.762330
Chicago Kılıç, Ahmet Osman, Hussein M.h. Atwan, Abdullah Yazar, and Fatih Akın. “Evaluation of Children With Acute Gastroenteritis in Konya Region”. Family Practice and Palliative Care 6, no. 1 (April 2021): 1-6. https://doi.org/10.22391/fppc.762330.
EndNote Kılıç AO, Atwan HM, Yazar A, Akın F (April 1, 2021) Evaluation of children with acute gastroenteritis in Konya region. Family Practice and Palliative Care 6 1 1–6.
IEEE A. O. Kılıç, H. M. Atwan, A. Yazar, and F. Akın, “Evaluation of children with acute gastroenteritis in Konya region”, Fam Pract Palliat Care, vol. 6, no. 1, pp. 1–6, 2021, doi: 10.22391/fppc.762330.
ISNAD Kılıç, Ahmet Osman et al. “Evaluation of Children With Acute Gastroenteritis in Konya Region”. Family Practice and Palliative Care 6/1 (April2021), 1-6. https://doi.org/10.22391/fppc.762330.
JAMA Kılıç AO, Atwan HM, Yazar A, Akın F. Evaluation of children with acute gastroenteritis in Konya region. Fam Pract Palliat Care. 2021;6:1–6.
MLA Kılıç, Ahmet Osman et al. “Evaluation of Children With Acute Gastroenteritis in Konya Region”. Family Practice and Palliative Care, vol. 6, no. 1, 2021, pp. 1-6, doi:10.22391/fppc.762330.
Vancouver Kılıç AO, Atwan HM, Yazar A, Akın F. Evaluation of children with acute gastroenteritis in Konya region. Fam Pract Palliat Care. 2021;6(1):1-6.

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Archives of Virology
https://doi.org/10.1007/s00705-023-05950-z

Family Practice and Palliative Care       ISSN 2458-8865       E-ISSN 2459-1505