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Research Article
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The autoantibody frequency in patients with drug allergy

Year 2022, Volume: 7 Issue: 4, 97 - 102, 19.10.2022

Zeynep Altın , Papatya Bayrak Değirmenci

https://doi.org/10.22391/fppc.1134893

Abstract

Introduction: This study is aimed to analyze the autoantibody frequency in patients with drug allergy. Descriptive, observational research on drug allergy will contribute to the creation of new hypotheses about the pathophysiology of autoimmunity.
Methods: The data of patients who were registered in the Training and Research Hospital database until the end of December 31, 2018 and diagnosed with drug allergy were retrospectively evaluated. Overall, 617 adult patients who had been diagnosed as “allergy status to drugs,” according to ICD 10, and had had at least one autoantibody result were included in the study.
Results: The frequency of having at least one autoantibody varied between 0% and 92.1%. The most commonly detected autoantibody was rheumatoid factor (RF) (n = 241; 92.1%). The second most common one was anti-tissue transglutaminase IgA antibody (Anti-tTG-IgA) (n=22; 68.2%). The frequencies of anti-thyroglobulin (Anti-TG), anti-thyroid peroxidase (anti-TPO), and anti-double stranded DNA (Anti-dsDNA) were 65.2% (n = 155), 59.7% (n = 159), and 43.6% (n= 55), respectively.
Conclusions: Many drugs can trigger the development of autoantibodies with no progression to autoimmune disease. Autoantibodies should be suspected in patients with allergies to medications. Observational research on drug allergy will contribute to the creation of new hypotheses about the pathophysiology of autoimmunity. Numerous studies in this area can enable us to discuss the widespread use of risky drugs in a more objective way. We think that our study will shed light on the relationship between drug reaction and autoimmune diseases.
Keywords: Autoantibodies, autoimmunity, drug allergy, drug hypersensitivity 

Keywords

Autoantibodies autoimmunity drug allergy drug hypersensitivity

References

  • 1. Pichler WJ, Adam J, Watkins S, Wuillemin N, Yun J, Yerly D. Drug hypersensitivity: how drugs stimulate T cells via pharmacological interaction with immune receptors. Int Arch Allergy Immunol 2015;168:13-24. https://doi.org/10.1159/000441280
  • 2. Olsen NJ. Drug-induced autoimmunity. Best Pract Res Clin Rheumatol. 2004;18(5):677-88 https://doi.org/10.1016/j.berh.2004.05.006
  • 3. Chang C, Gershwin ME. Drugs and autoimmunity--a contemporary review and mechanistic approach. J Autoimmun. 2010;34(3):J266-75. https://doi.org/10.1016/j.jaut.2009.11.012
  • 4. Dedeoglu F. Drug-induced autoimmunity. Curr Opin Rheumatol. 2009;21(5):547-51. https://doi.org/10.1097/BOR.0b013e32832f13db
  • 5. Xiao X, Chang C. Diagnosis and classification of drug-induced autoimmunity (DIA). J Autoimmun. 2014;48-49:66-72. https://doi.org/10.1016/j.jaut.2014.01.005
  • 6. Colombo G, Yacoub MR, Burastero SE, Garattini E, Girlanda S, Saporiti N et al. Multiple drug hypersensitivity: insight into the underlying mechanism and correlation with autoimmune diseases. Eur Ann Allergy Clin Immunol. 2009;41(2):50-5. https://pubmed.ncbi.nlm.nih.gov/19585860/
  • 7. Lenth RV. Java applets for power and sample size [computer software]. Available at: http://homepage.divms.uiowa.edu/~rlenth/Power/. (Access Date: October 4, 2022)
  • 8. Falcao PL, Campos TPR. The role of regulatory T cells, interleukin-10 and in vivo scintigraphy in autoimmune and idiopathic diseases - Therapeutic perspectives and prognosis. Rev Assoc Med Bras. 2017;63(12):1090-9. https://doi.org/10.1590/1806-9282.63.12.1090
  • 9. Todoric K, Koontz JB, Mattox D, Tarrant TK. Autoimmunity in immunodeficiency. Curr Allergy Asthma Rep. 2013;13(4):361-70. https://doi.org/10.1007/s11882-013-0350-3
  • 10. Missaka RF, Penatti HC, Silvares MR, Nogueira CR, Mazeto GM. Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study. Sao Paulo Med J. 2012;130(5):294-8. https://pubmed.ncbi.nlm.nih.gov/23174868/
  • 11. Yung JA, Fuseini H, Newcomb DC. Hormones, sex, and asthma. Ann Allergy Asthma Immunol. 2018;120(5):488-94. https://doi.org/10.1016/j.anai.2018.01.016
  • 12. Eaddy NA, Broyles AD. Drug allergy in children and adults: is it the double X chromosome? Ann Allergy Asthma Immunol. 2019;122(2):148-55. https://doi.org/10.1016/j.anai.2018.11.014
  • 13. Iasella CJ, Johnson HJ, Dunn MA. Adverse drug reactions: type A (Intrinsic) or type B (Idiosyncratic). Clin Liver Dis. 2017;21(1):73-87. https://doi.org/10.1016/j.cld.2016.08.005
  • 14. Coleman JJ, Pontefract SK. Adverse drug reactions. Clin Med (Lond). 2016;16(5):481-5. https://doi.org/10.7861/clinmedicine.16-5-481
  • 15. Fernandes MR, Barreto WDR. Association between physical activity and vitamin D: a narrative literature review. Rev Assoc Med Bras. 2017;63(6):550-6. https://doi.org/10.1590/1806-9282.63.06.550
  • 16. Eugenio G, Tavares J, Ferreira JF, Malcata A. Unusual association between erythema nodosum and autoimmune atrophic gastritis. BMJ Case Rep. 2018;15;2018:bcr2017223638. https://doi.org/10.1136/bcr-2017-223638
  • 17. Lima CM, Schroeder JT, Galvao CES, Castro FM , Kalil J , Adkinson NF. Functional changes of dendritic cells in hypersensivity reactions to amoxicillin. Braz J Med Biol Res. 2010;43(10):964-8. https://pubmed.ncbi.nlm.nih.gov/20878012/
  • 18. Gianfrani C, Pisapia L, Picascia S, Strazzullo M, Del Pozzo G. Expression level of risk genes of MHC class II is a susceptibility factor for autoimmunity: New insights. J Autoimmun. 2018;89:1-10. https://doi.org/10.1016/j.jaut.2017.12.016
  • 19. He Y, Sawalha AH. Drug-induced lupus erythematosus: an update on drugs and mechanisms. Curr Opin Rheumatol. 2018;30(5):490-7. https://doi.org/10.1097/BOR.0000000000000522
  • 20. Bojinca VC, Bojinca M, Gheorghe M, Birceanu A, Iosif CI, Balanescu SM, et al. Stevens-Johnsons syndrome or drug-induced lupus - a clinical dilemma: a case report and review of the literature. Biomed Rep. 2018;9(1):37-41. https://doi.org/10.3892/br.2018.1098
  • 21. Licata A. Adverse drug reactions and organ damage: the liver. Eur J Intern Med. 2016;28:9-16. https://doi.org/10.1016/j.ejim.2015.12.017
  • 22. Marzano AV, Borghi A, Cugno M. Adverse drug reactions and organ damage: the skin. Eur J Intern Med. 2016;28:17-24. https://doi.org/10.1016/j.ejim.2015.11.017
  • 23. Siachoque H, Satisteban N, Gamarra AI. T regulatory lymphocytes: subpopulations, mechanism of action and importance in the control of autoimmunity. Revista colombiana de reumatologia. 2011;18(3):203-20. https://doi.org/10.1016/S0121-8123(11)70054-8

İlaç alerjisi olan hastalarda otoantikor sıklığı

Year 2022, Volume: 7 Issue: 4, 97 - 102, 19.10.2022

Zeynep Altın , Papatya Bayrak Değirmenci

https://doi.org/10.22391/fppc.1134893

Abstract

Giriş: Bu çalışma, ilaç alerjisi olan hastalarda otoantikor sıklığını incelemeyi amaçlamaktadır. İlaç alerjisi üzerine gözlemsel araştırmalar, otoimmünite patofizyolojisi hakkında yeni hipotezlerin oluşturulmasına katkıda bulunabilir.

Yöntem: Eğitim ve Araştırma Hastanesi veri tabanına 31 Aralık 2018 sonuna kadar kayıt olan ve ilaç alerjisi tanısı konan hastaların verileri geriye dönük olarak değerlendirildi. Genel olarak, ICD 10'a göre “ilaçlara alerji durumu” tanısı konan ve en az bir otoantikor sonucu olan 617 adet yetişkin hasta çalışmaya dahil edildi.

Bulgular: Araştırmada en az bir otoantikora sahip olma sıklığı % 0 ile % 92,1 arasında değişti. En sık saptanan otoantikor romatoid faktör (RF) idi (n = 241; % 92,1). İkinci en sık rastlanan oto antikorun anti-doku transglütaminaz IgA (Anti-tTG-IgA) (n = 22; % 68,2) olduğu görüldü. Anti-tiroglobulin (Anti-TG), anti-tiroid peroksidaz (anti-TPO) ve anti-çift sarmallı DNA (Anti-dsDNA) sıklıkları sırasıyla % 65,2 (n = 155), % 59,7 (n = 159) ve % 43,6 (n = 55) olarak saptandı.

Sonuç: Birçok ilaç, otoimmün hastalıkları için ilerleme olmaksızın otoantikor gelişimini tetikleyebilir. İlaçlara alerjisi olan hastalarda otoantikorlardan şüphelenilmesi gereklidir. İlaç alerjisi üzerine yapılan gözlemsel araştırmalar, otoimmünitenin patofizyolojisi hakkında yeni hipotezlerin oluşturulmasına katkı sağlayacaktır. Bu alanda yapılacak çok sayıda çalışma, riskli ilaçların yaygın kullanımını daha objektif bir şekilde tartışmamızı sağlayabilir. Çalışmamızın ilaç reaksiyonu ile otoimmün hastalıklar arasındaki ilişkiye ışık tutacağını düşünüyoruz.

Anahtar kelimeler: Otoantikorlar, otoimmünite, ilaç alerjisi, ilaç aşırı duyarlılığı

Keywords

Otoantikorlar otoimmünite ilaç alerjisi ilaç aşırı duyarlılığı

References

  • 1. Pichler WJ, Adam J, Watkins S, Wuillemin N, Yun J, Yerly D. Drug hypersensitivity: how drugs stimulate T cells via pharmacological interaction with immune receptors. Int Arch Allergy Immunol 2015;168:13-24. https://doi.org/10.1159/000441280
  • 2. Olsen NJ. Drug-induced autoimmunity. Best Pract Res Clin Rheumatol. 2004;18(5):677-88 https://doi.org/10.1016/j.berh.2004.05.006
  • 3. Chang C, Gershwin ME. Drugs and autoimmunity--a contemporary review and mechanistic approach. J Autoimmun. 2010;34(3):J266-75. https://doi.org/10.1016/j.jaut.2009.11.012
  • 4. Dedeoglu F. Drug-induced autoimmunity. Curr Opin Rheumatol. 2009;21(5):547-51. https://doi.org/10.1097/BOR.0b013e32832f13db
  • 5. Xiao X, Chang C. Diagnosis and classification of drug-induced autoimmunity (DIA). J Autoimmun. 2014;48-49:66-72. https://doi.org/10.1016/j.jaut.2014.01.005
  • 6. Colombo G, Yacoub MR, Burastero SE, Garattini E, Girlanda S, Saporiti N et al. Multiple drug hypersensitivity: insight into the underlying mechanism and correlation with autoimmune diseases. Eur Ann Allergy Clin Immunol. 2009;41(2):50-5. https://pubmed.ncbi.nlm.nih.gov/19585860/
  • 7. Lenth RV. Java applets for power and sample size [computer software]. Available at: http://homepage.divms.uiowa.edu/~rlenth/Power/. (Access Date: October 4, 2022)
  • 8. Falcao PL, Campos TPR. The role of regulatory T cells, interleukin-10 and in vivo scintigraphy in autoimmune and idiopathic diseases - Therapeutic perspectives and prognosis. Rev Assoc Med Bras. 2017;63(12):1090-9. https://doi.org/10.1590/1806-9282.63.12.1090
  • 9. Todoric K, Koontz JB, Mattox D, Tarrant TK. Autoimmunity in immunodeficiency. Curr Allergy Asthma Rep. 2013;13(4):361-70. https://doi.org/10.1007/s11882-013-0350-3
  • 10. Missaka RF, Penatti HC, Silvares MR, Nogueira CR, Mazeto GM. Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study. Sao Paulo Med J. 2012;130(5):294-8. https://pubmed.ncbi.nlm.nih.gov/23174868/
  • 11. Yung JA, Fuseini H, Newcomb DC. Hormones, sex, and asthma. Ann Allergy Asthma Immunol. 2018;120(5):488-94. https://doi.org/10.1016/j.anai.2018.01.016
  • 12. Eaddy NA, Broyles AD. Drug allergy in children and adults: is it the double X chromosome? Ann Allergy Asthma Immunol. 2019;122(2):148-55. https://doi.org/10.1016/j.anai.2018.11.014
  • 13. Iasella CJ, Johnson HJ, Dunn MA. Adverse drug reactions: type A (Intrinsic) or type B (Idiosyncratic). Clin Liver Dis. 2017;21(1):73-87. https://doi.org/10.1016/j.cld.2016.08.005
  • 14. Coleman JJ, Pontefract SK. Adverse drug reactions. Clin Med (Lond). 2016;16(5):481-5. https://doi.org/10.7861/clinmedicine.16-5-481
  • 15. Fernandes MR, Barreto WDR. Association between physical activity and vitamin D: a narrative literature review. Rev Assoc Med Bras. 2017;63(6):550-6. https://doi.org/10.1590/1806-9282.63.06.550
  • 16. Eugenio G, Tavares J, Ferreira JF, Malcata A. Unusual association between erythema nodosum and autoimmune atrophic gastritis. BMJ Case Rep. 2018;15;2018:bcr2017223638. https://doi.org/10.1136/bcr-2017-223638
  • 17. Lima CM, Schroeder JT, Galvao CES, Castro FM , Kalil J , Adkinson NF. Functional changes of dendritic cells in hypersensivity reactions to amoxicillin. Braz J Med Biol Res. 2010;43(10):964-8. https://pubmed.ncbi.nlm.nih.gov/20878012/
  • 18. Gianfrani C, Pisapia L, Picascia S, Strazzullo M, Del Pozzo G. Expression level of risk genes of MHC class II is a susceptibility factor for autoimmunity: New insights. J Autoimmun. 2018;89:1-10. https://doi.org/10.1016/j.jaut.2017.12.016
  • 19. He Y, Sawalha AH. Drug-induced lupus erythematosus: an update on drugs and mechanisms. Curr Opin Rheumatol. 2018;30(5):490-7. https://doi.org/10.1097/BOR.0000000000000522
  • 20. Bojinca VC, Bojinca M, Gheorghe M, Birceanu A, Iosif CI, Balanescu SM, et al. Stevens-Johnsons syndrome or drug-induced lupus - a clinical dilemma: a case report and review of the literature. Biomed Rep. 2018;9(1):37-41. https://doi.org/10.3892/br.2018.1098
  • 21. Licata A. Adverse drug reactions and organ damage: the liver. Eur J Intern Med. 2016;28:9-16. https://doi.org/10.1016/j.ejim.2015.12.017
  • 22. Marzano AV, Borghi A, Cugno M. Adverse drug reactions and organ damage: the skin. Eur J Intern Med. 2016;28:17-24. https://doi.org/10.1016/j.ejim.2015.11.017
  • 23. Siachoque H, Satisteban N, Gamarra AI. T regulatory lymphocytes: subpopulations, mechanism of action and importance in the control of autoimmunity. Revista colombiana de reumatologia. 2011;18(3):203-20. https://doi.org/10.1016/S0121-8123(11)70054-8
There are 23 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Original Research
Authors

Zeynep Altın 0000-0003-3682-1479

Papatya Bayrak Değirmenci 0000-0003-0039-302X

Publication Date October 19, 2022
Submission Date June 23, 2022
Acceptance Date September 15, 2022
Published in Issue Year 2022 Volume: 7 Issue: 4

Cite

APA Altın, Z., & Bayrak Değirmenci, P. (2022). The autoantibody frequency in patients with drug allergy. Family Practice and Palliative Care, 7(4), 97-102. https://doi.org/10.22391/fppc.1134893
AMA Altın Z, Bayrak Değirmenci P. The autoantibody frequency in patients with drug allergy. Fam Pract Palliat Care. October 2022;7(4):97-102. doi:10.22391/fppc.1134893
Chicago Altın, Zeynep, and Papatya Bayrak Değirmenci. “The Autoantibody Frequency in Patients With Drug Allergy”. Family Practice and Palliative Care 7, no. 4 (October 2022): 97-102. https://doi.org/10.22391/fppc.1134893.
EndNote Altın Z, Bayrak Değirmenci P (October 1, 2022) The autoantibody frequency in patients with drug allergy. Family Practice and Palliative Care 7 4 97–102.
IEEE Z. Altın and P. Bayrak Değirmenci, “The autoantibody frequency in patients with drug allergy”, Fam Pract Palliat Care, vol. 7, no. 4, pp. 97–102, 2022, doi: 10.22391/fppc.1134893.
ISNAD Altın, Zeynep - Bayrak Değirmenci, Papatya. “The Autoantibody Frequency in Patients With Drug Allergy”. Family Practice and Palliative Care 7/4 (October2022), 97-102. https://doi.org/10.22391/fppc.1134893.
JAMA Altın Z, Bayrak Değirmenci P. The autoantibody frequency in patients with drug allergy. Fam Pract Palliat Care. 2022;7:97–102.
MLA Altın, Zeynep and Papatya Bayrak Değirmenci. “The Autoantibody Frequency in Patients With Drug Allergy”. Family Practice and Palliative Care, vol. 7, no. 4, 2022, pp. 97-102, doi:10.22391/fppc.1134893.
Vancouver Altın Z, Bayrak Değirmenci P. The autoantibody frequency in patients with drug allergy. Fam Pract Palliat Care. 2022;7(4):97-102.
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Family Practice and Palliative Care       ISSN 2458-8865       E-ISSN 2459-1505