Correlation of voice and quality of life with adjuvant radiotherapy in patients with larynx cancer

Medine Kara; Hülya Ertekin; Başak Şahin; Sibel Cevizci; Fevzi Sefa Dereköy

doi:10.22391/920.308837

Research Article

Larenks kanserli hastalarda adjuvant radyoterapinin ses ve yaşam kalitesi ile ilişkisi

Year 2017, Volume: 2 Issue: 1, 9 - 16, 25.04.2017

Medine Kara Hülya Ertekin Başak Şahin Sibel Cevizci Fevzi Sefa Dereköy

https://doi.org/10.22391/920.308837

Cited By: 2

Abstract

Giriş: Bu çalışmanın
amacı larenks kanserli hastalarda ameliyat tipi ve adjuvant radyoterapinin (RT)
hastaların ses ve yaşam kalitesi üzerindeki etkisini araştırmaktır.

Yöntem: Larenks kanseri
nedeni ile ameliyat edilen 38 hasta (37 erkek, 1 kadın; ort. yaş 63,6 ± 9,63 yıl) bu çalışmaya dahil edildi. Tanı
esnasındaki tümör lokalizasyonu, TNM evrelemesi, uygulanan ameliyat tipi,
adjuvant/primer RT alımı, nüks varlığı ve postoperatif takip süresi kaydedildi.
Tüm katılımcıların öznel ses handikap indeksi (VHI-10) ve Washington
Üniversitesi Yaşam Kalitesi Anketi versiyon-IV (UWQOL-4) ile ses ve yaşam kalitesi
skorları hesaplandı. Ses analizi Xion Endo Strop-DX sistemi ile
gerçekleştirildi. Anket skorları ve ses parametreleri gruplar arasında
karşılaştırıldı.

Bulgular: VHI ortalamaları
stripping/kordektomi grubunda, parsiyel veya total larenjektomi gruplarına göre
istatistiksel olarak daha düşüktü. ortalama SPLmin, MFZ ve UWQOL’ın ağrı,
görünüş, yutma ve çiğneme puan ortalamaları RT almayan grupta RT alan gruptan
daha yüksek idi. VHI ve yaşam kalitesi parametreleri arasında bir negatif yönlü
bir korelasyon saptandı.

Sonuç: İleri evre
larenks kanserlerinde artan cerrahi manüpülasyonlar ve adjuvant RT ihtiyacı
hastaların ağrı, ses, konuşma, yutma, çiğneme fonksiyonlarını etkileyerek yaşam
kalitesini düşürmektedir. Bu nedenle hastalığın erken tanınıp tedavisinin
planlanması oldukça önemlidir. Öznel ses kalitesi arttıkça yaşam kalitesi
skorlarının da artmış olması hastaların tedavi sonrası ses terapisine ve
psikoterapiye yönlendirilmelerinin önemini bir kez daha göstermektedir.

Keywords

Larenks Kanseri, Adjuvan Radyoterapi, Yaşam Kalitesi, Washington Üniversitesi Yaşam Kalitesi Anketi, Ses Kalitesi, Ses Handikap İndeksi-10

References

1. Karabulut B, Basaran B, Yenice H, Ulusan M, Orhan KS, Hafiz G. The relationship between operation type, adjuvant radiation therapy, spinal accessory nerve and quality of life in patients with laryngeal cancer. Kulak Burun Bogaz Ihtis Derg. 2013;23:153-62. doi:10.5606/kbbihtisas.2013.89410.
2. Attar E, Dey S, Hablas A, Seifeldin IA, Ramadan M, Rozek LS, et al. Head and neck cancer in a developing country: a population-based perspective across 8 years. Oral Oncol. 2010;46:591-6. doi:10.1016/j.oraloncology.2010.05.002.
3. Vartanian JG, Carvalho AL, Yueh B, Priante AV, de Melo RL, Correia LM, et al. Long-term quality-of-life evaluation after head and neck cancer treatment in a developing country. Arch Otolaryngol Head Neck Surg. 2004;130:1209-13. doi:10.1001/archotol.130.10.1209.
4. Deleyiannis FW, Weymuller EA, Coltrera MD, Futran N. Quality of life after laryngectomy: are functional disabilities important? Head Neck. 1999;21:319-24. http://www.ncbi.nlm.nih.gov/pubmed/10376751.
5. Allal AS, Nicoucar K, Mach N, Dulguerov P. Quality of life in patients with oropharynx carcinomas: assessment after accelerated radiotherapy with or without chemotherapy versus radical surgery and postoperative radiotherapy. Head Neck. 2003;25:833-9. doi:10.1002/hed.10302.
6. Morton RP, Izzard ME. Quality-of-life outcomes in head and neck cancer patients. World J Surg. 2003;27:884-9. http://www.ncbi.nlm.nih.gov/pubmed/14509523.
7. List MA, Stracks J. Evaluation of quality of life in patients definitively treated for squamous carcinoma of the head and neck. Curr Opin Oncol. 2000;12:215-20. http://www.ncbi.nlm.nih.gov/pubmed/10841193.
8. Ringash J, Bezjak A. A structured review of quality of life instruments for head and neck cancer patients. Head Neck. 2001;23:201-13. http://www.ncbi.nlm.nih.gov/pubmed/11428450.
9. Rogers SN, Gwanne S, Lowe D, Humphris G, Yueh B, Weymuller EA. The addition of mood and anxiety domains to the University of Washington quality of life scale. Head Neck. 2002;24:521-9. doi:10.1002/hed.10106.
10. Senkal HA, Hayran M, Karakaya E, Yueh B, Weymuller EA, Hoşal AŞ. The validity and reliability of the Turkish version of the University of Washington Quality of Life Questionnaire for patients with head and neck cancer. Am J Otolaryngol. 2012;33:417-26. doi:10.1016/j.amjoto.2011.10.014.
11. Kiliç MA, Okur E, Yildirim I, Oğüt F, Denizoğlu I, Kizilay A, et al. Reliability and validity of the Turkish version of the Voice Handicap Index. Kulak Burun Bogaz Ihtis Derg. 2008;18:139-47.
12. Weymuller EA, Yueh B, Deleyiannis FW, Kuntz AL, Alsarraf R, Coltrera MD. Quality of life in patients with head and neck cancer: lessons learned from 549 prospectively evaluated patients. Arch Otolaryngol Head Neck Surg. 2000;126:329-36. http://www.ncbi.nlm.nih.gov/pubmed/10722005.
13. Gritz ER, Carmack CL, de Moor C, Coscarelli A, Schacherer CW, Meyers EG, et al. First year after head and neck cancer: quality of life. J Clin Oncol. 1999;17:352-60. http://www.ncbi.nlm.nih.gov/pubmed/10458254.
14. Murphy BA, Ridner S, Wells N, Dietrich M. Quality of life research in head and neck cancer: a review of the current state of the science. Crit Rev Oncol Hematol. 2007;62:251-67. doi:10.1016/j.critrevonc.2006.07.005.
15. Hammerlid E, Mercke C, Sullivan M, Westin T. A prospective quality of life study of patients with laryngeal carcinoma by tumor stage and different radiation therapy schedules. Laryngoscope. 1998;108:747-59. doi:10.1097/00005537-199805000-00023.
16. Finizia C, Hammerlid E, Westin T, Lindström J. Quality of life and voice in patients with laryngeal carcinoma: a posttreatment comparison of laryngectomy (salvage surgery) versus radiotherapy. Laryngoscope. 1998;108:1566-73. http://www.ncbi.nlm.nih.gov/pubmed/9778303.
17. Allal AS, Dulguerov P, Bieri S, Lehmann W, Kurtz JM. Assessment of quality of life in patients treated with accelerated radiotherapy for laryngeal and hypopharyngeal carcinomas. Head Neck. 2000;22:288-93. http://www.ncbi.nlm.nih.gov/pubmed/10748453.
18. Kuntz AL, Weymuller EA. Impact of neck dissection on quality of life. Laryngoscope. 1999;109:1334-8. doi:10.1097/00005537-199908000-00030.
19. Erisen L, Basel B, Irdesel J, Zarifoglu M, Coskun H, Basut O, et al. Shoulder function after accessory nerve-sparing neck dissections. Head Neck. 2004;26:967-71. doi:10.1002/hed.20095.
20. Orhan KS, Demirel T, Baslo B, Orhan EK, Yücel EA, Güldiken Y, et al. Spinal accessory nerve function after neck dissections. J Laryngol Otol. 2007;121:44-8. doi:10.1017/S0022215106002052.
21. Cappiello J, Piazza C, Nicolai P. The spinal accessory nerve in head and neck surgery. Curr Opin Otolaryngol Head Neck Surg. 2007;15:107-11. doi:10.1097/MOO.0b013e3280523ac5.
22. Timmermans B, De Bodt M, Wuyts F, Van de Heyning P. Voice quality change in future professional voice users after 9 months of voice training. Eur Arch Otorhinolaryngol. 2004;261:1-5. doi:10.1007/s00405-003-0652-5.
23. Silva DG, Oliveira LC, Andrea M. Jitter Estimation Algorithms for Detection of Pathological Voices. EURASIP J Adv Signal Process. 2009;2009:1-9. Article ID 567875. doi:10.1155/2009/567875.
24. Sanal A, Kandoğan T, Gültekin G, Olgun L, Cerçi U. Evaluation of dysphonia in partial laryngectomy patients. Kulak Burun Bogaz Ihtis Derg. 2006;16:54-9.
25. Nordenberg M, Sundberg J. Effect on LTAS of vocal loudness variation. TMH-QPSR. 2003;45:93-100.
26. Wuyts FL, De Bodt MS, Molenberghs G, Remacle M, Heylen L, Millet B, et al. The dysphonia severity index: an objective measure of vocal quality based on a multiparameter approach. J Speech Lang Hear Res. 2000;43:796-809. http://www.ncbi.nlm.nih.gov/pubmed/10877446.
27. Eadie TL, Day AMB, Sawin DE, Lamvik K, Doyle PC. Auditory-perceptual speech outcomes and quality of life after total laryngectomy. Otolaryngol Head Neck Surg. 2013;148:82-8. doi:10.1177/0194599812461755.
28. Polat B, Orhan KS, Kesimli MC, Gorgulu Y, Ulusan M, Deger K. The effects of indwelling voice prosthesis on the quality of life, depressive symptoms, and self-esteem in patients with total laryngectomy. Eur Arch Otorhinolaryngol. 2014;272:3431-7. doi:10.1007/s00405-014-3335-5.
29. Hanna E, Sherman A, Cash D, Adams D, Vural E, Fan CY, et al. Quality of life for patients following total laryngectomy vs chemoradiation for laryngeal preservation. Arch Otolaryngol Head Neck Surg. 2004;130:875-9. doi:10.1001/archotol.130.7.875.
30. Tuomi L, Johansson M, Lindell E, Folkestad L, Malmerfors M, Finizia C. Voice Range Profile and Health-related Quality of Life Measurements Following Voice Rehabilitation After Radiotherapy; a Randomized Controlled Study. J Voice. 2016 Apr 15. pii: S0892-1997(16)30010-8. doi: 10.1016/j.jvoice.2016.03.012.

Correlation of voice and quality of life with adjuvant radiotherapy in patients with larynx cancer

Year 2017, Volume: 2 Issue: 1, 9 - 16, 25.04.2017

Medine Kara Hülya Ertekin Başak Şahin Sibel Cevizci Fevzi Sefa Dereköy

https://doi.org/10.22391/920.308837

Cited By: 2

Abstract

Introduction: To evaluate the
effect of surgery type and adjuvant radiotherapy (RT) on voice quality and
quality of life in patients with larynx cancer.

Methods: 38 patients with
larynx cancer (37 males, 1 female; mean age 63.6 ± 9.63 years) were included in
this study. The parameters including tumor localization, TNM staging, and type
of surgery performed, adjuvant/primary RT intake and recurrence were recorded.
All participants filled voice handicap index (VHI-10) and University of Washington
Quality of Life Questionnaire version-IV (UWQOL-4). Voice analysis was
performed by Xion Endo Strop-DX system. Questionnaire scores and voice
parameters were compared between groups.

Results: There was a
statistically significant low mean values of VHI detected within the group of
stripping/cordectomy compared to groups of partial or total laryngectomy. In
the group without RT, the mean values of SPLmin, MPT, pain, appearance,
swallowing and chewing subgroups of UWQOL scale were higher than the group treated
with RT. There was a negative correlation identified between VHI and QOL
parameters.

Conclusion: In advanced stage
larynx cancer, increased surgical manipulation and adjuvant RT requirements
decrease QOL. As a result early diagnosis of disease and treatment is very
important. As subjective voice quality increases QOL scores rise, indicating
the importance of referring patients for voice therapy and psychotherapy after
treatment.

Keywords

Laryngeal Neoplasms, Radiotherapy/Adjuvant, quality of life, University of Washington Quality of Life Questionnaire version-IV, Voice quality, VHI-10

References

1. Karabulut B, Basaran B, Yenice H, Ulusan M, Orhan KS, Hafiz G. The relationship between operation type, adjuvant radiation therapy, spinal accessory nerve and quality of life in patients with laryngeal cancer. Kulak Burun Bogaz Ihtis Derg. 2013;23:153-62. doi:10.5606/kbbihtisas.2013.89410.
2. Attar E, Dey S, Hablas A, Seifeldin IA, Ramadan M, Rozek LS, et al. Head and neck cancer in a developing country: a population-based perspective across 8 years. Oral Oncol. 2010;46:591-6. doi:10.1016/j.oraloncology.2010.05.002.
3. Vartanian JG, Carvalho AL, Yueh B, Priante AV, de Melo RL, Correia LM, et al. Long-term quality-of-life evaluation after head and neck cancer treatment in a developing country. Arch Otolaryngol Head Neck Surg. 2004;130:1209-13. doi:10.1001/archotol.130.10.1209.
4. Deleyiannis FW, Weymuller EA, Coltrera MD, Futran N. Quality of life after laryngectomy: are functional disabilities important? Head Neck. 1999;21:319-24. http://www.ncbi.nlm.nih.gov/pubmed/10376751.
5. Allal AS, Nicoucar K, Mach N, Dulguerov P. Quality of life in patients with oropharynx carcinomas: assessment after accelerated radiotherapy with or without chemotherapy versus radical surgery and postoperative radiotherapy. Head Neck. 2003;25:833-9. doi:10.1002/hed.10302.
6. Morton RP, Izzard ME. Quality-of-life outcomes in head and neck cancer patients. World J Surg. 2003;27:884-9. http://www.ncbi.nlm.nih.gov/pubmed/14509523.
7. List MA, Stracks J. Evaluation of quality of life in patients definitively treated for squamous carcinoma of the head and neck. Curr Opin Oncol. 2000;12:215-20. http://www.ncbi.nlm.nih.gov/pubmed/10841193.
8. Ringash J, Bezjak A. A structured review of quality of life instruments for head and neck cancer patients. Head Neck. 2001;23:201-13. http://www.ncbi.nlm.nih.gov/pubmed/11428450.
9. Rogers SN, Gwanne S, Lowe D, Humphris G, Yueh B, Weymuller EA. The addition of mood and anxiety domains to the University of Washington quality of life scale. Head Neck. 2002;24:521-9. doi:10.1002/hed.10106.
10. Senkal HA, Hayran M, Karakaya E, Yueh B, Weymuller EA, Hoşal AŞ. The validity and reliability of the Turkish version of the University of Washington Quality of Life Questionnaire for patients with head and neck cancer. Am J Otolaryngol. 2012;33:417-26. doi:10.1016/j.amjoto.2011.10.014.
11. Kiliç MA, Okur E, Yildirim I, Oğüt F, Denizoğlu I, Kizilay A, et al. Reliability and validity of the Turkish version of the Voice Handicap Index. Kulak Burun Bogaz Ihtis Derg. 2008;18:139-47.
12. Weymuller EA, Yueh B, Deleyiannis FW, Kuntz AL, Alsarraf R, Coltrera MD. Quality of life in patients with head and neck cancer: lessons learned from 549 prospectively evaluated patients. Arch Otolaryngol Head Neck Surg. 2000;126:329-36. http://www.ncbi.nlm.nih.gov/pubmed/10722005.
13. Gritz ER, Carmack CL, de Moor C, Coscarelli A, Schacherer CW, Meyers EG, et al. First year after head and neck cancer: quality of life. J Clin Oncol. 1999;17:352-60. http://www.ncbi.nlm.nih.gov/pubmed/10458254.
14. Murphy BA, Ridner S, Wells N, Dietrich M. Quality of life research in head and neck cancer: a review of the current state of the science. Crit Rev Oncol Hematol. 2007;62:251-67. doi:10.1016/j.critrevonc.2006.07.005.
15. Hammerlid E, Mercke C, Sullivan M, Westin T. A prospective quality of life study of patients with laryngeal carcinoma by tumor stage and different radiation therapy schedules. Laryngoscope. 1998;108:747-59. doi:10.1097/00005537-199805000-00023.
16. Finizia C, Hammerlid E, Westin T, Lindström J. Quality of life and voice in patients with laryngeal carcinoma: a posttreatment comparison of laryngectomy (salvage surgery) versus radiotherapy. Laryngoscope. 1998;108:1566-73. http://www.ncbi.nlm.nih.gov/pubmed/9778303.
17. Allal AS, Dulguerov P, Bieri S, Lehmann W, Kurtz JM. Assessment of quality of life in patients treated with accelerated radiotherapy for laryngeal and hypopharyngeal carcinomas. Head Neck. 2000;22:288-93. http://www.ncbi.nlm.nih.gov/pubmed/10748453.
18. Kuntz AL, Weymuller EA. Impact of neck dissection on quality of life. Laryngoscope. 1999;109:1334-8. doi:10.1097/00005537-199908000-00030.
19. Erisen L, Basel B, Irdesel J, Zarifoglu M, Coskun H, Basut O, et al. Shoulder function after accessory nerve-sparing neck dissections. Head Neck. 2004;26:967-71. doi:10.1002/hed.20095.
20. Orhan KS, Demirel T, Baslo B, Orhan EK, Yücel EA, Güldiken Y, et al. Spinal accessory nerve function after neck dissections. J Laryngol Otol. 2007;121:44-8. doi:10.1017/S0022215106002052.
21. Cappiello J, Piazza C, Nicolai P. The spinal accessory nerve in head and neck surgery. Curr Opin Otolaryngol Head Neck Surg. 2007;15:107-11. doi:10.1097/MOO.0b013e3280523ac5.
22. Timmermans B, De Bodt M, Wuyts F, Van de Heyning P. Voice quality change in future professional voice users after 9 months of voice training. Eur Arch Otorhinolaryngol. 2004;261:1-5. doi:10.1007/s00405-003-0652-5.
23. Silva DG, Oliveira LC, Andrea M. Jitter Estimation Algorithms for Detection of Pathological Voices. EURASIP J Adv Signal Process. 2009;2009:1-9. Article ID 567875. doi:10.1155/2009/567875.
24. Sanal A, Kandoğan T, Gültekin G, Olgun L, Cerçi U. Evaluation of dysphonia in partial laryngectomy patients. Kulak Burun Bogaz Ihtis Derg. 2006;16:54-9.
25. Nordenberg M, Sundberg J. Effect on LTAS of vocal loudness variation. TMH-QPSR. 2003;45:93-100.
26. Wuyts FL, De Bodt MS, Molenberghs G, Remacle M, Heylen L, Millet B, et al. The dysphonia severity index: an objective measure of vocal quality based on a multiparameter approach. J Speech Lang Hear Res. 2000;43:796-809. http://www.ncbi.nlm.nih.gov/pubmed/10877446.
27. Eadie TL, Day AMB, Sawin DE, Lamvik K, Doyle PC. Auditory-perceptual speech outcomes and quality of life after total laryngectomy. Otolaryngol Head Neck Surg. 2013;148:82-8. doi:10.1177/0194599812461755.
28. Polat B, Orhan KS, Kesimli MC, Gorgulu Y, Ulusan M, Deger K. The effects of indwelling voice prosthesis on the quality of life, depressive symptoms, and self-esteem in patients with total laryngectomy. Eur Arch Otorhinolaryngol. 2014;272:3431-7. doi:10.1007/s00405-014-3335-5.
29. Hanna E, Sherman A, Cash D, Adams D, Vural E, Fan CY, et al. Quality of life for patients following total laryngectomy vs chemoradiation for laryngeal preservation. Arch Otolaryngol Head Neck Surg. 2004;130:875-9. doi:10.1001/archotol.130.7.875.
30. Tuomi L, Johansson M, Lindell E, Folkestad L, Malmerfors M, Finizia C. Voice Range Profile and Health-related Quality of Life Measurements Following Voice Rehabilitation After Radiotherapy; a Randomized Controlled Study. J Voice. 2016 Apr 15. pii: S0892-1997(16)30010-8. doi: 10.1016/j.jvoice.2016.03.012.

There are 30 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Original Research
Authors	Medine Kara Hülya Ertekin Başak Şahin Sibel Cevizci Fevzi Sefa Dereköy
Publication Date	April 25, 2017
Submission Date	October 26, 2016
Acceptance Date	March 30, 2017
Published in Issue	Year 2017Volume: 2 Issue: 1

Cite

APA	Kara, M., Ertekin, H., Şahin, B., Cevizci, S., et al. (2017). Correlation of voice and quality of life with adjuvant radiotherapy in patients with larynx cancer. Family Practice and Palliative Care, 2(1), 9-16. https://doi.org/10.22391/920.308837
AMA	Kara M, Ertekin H, Şahin B, Cevizci S, Dereköy FS. Correlation of voice and quality of life with adjuvant radiotherapy in patients with larynx cancer. Fam Pract Palliat Care. April 2017;2(1):9-16. doi:10.22391/920.308837
Chicago	Kara, Medine, Hülya Ertekin, Başak Şahin, Sibel Cevizci, and Fevzi Sefa Dereköy. “Correlation of Voice and Quality of Life With Adjuvant Radiotherapy in Patients With Larynx Cancer”. Family Practice and Palliative Care 2, no. 1 (April 2017): 9-16. https://doi.org/10.22391/920.308837.
EndNote	Kara M, Ertekin H, Şahin B, Cevizci S, Dereköy FS (April 1, 2017) Correlation of voice and quality of life with adjuvant radiotherapy in patients with larynx cancer. Family Practice and Palliative Care 2 1 9–16.
IEEE	M. Kara, H. Ertekin, B. Şahin, S. Cevizci, and F. S. Dereköy, “Correlation of voice and quality of life with adjuvant radiotherapy in patients with larynx cancer”, Fam Pract Palliat Care, vol. 2, no. 1, pp. 9–16, 2017, doi: 10.22391/920.308837.
ISNAD	Kara, Medine et al. “Correlation of Voice and Quality of Life With Adjuvant Radiotherapy in Patients With Larynx Cancer”. Family Practice and Palliative Care 2/1 (April 2017), 9-16. https://doi.org/10.22391/920.308837.
JAMA	Kara M, Ertekin H, Şahin B, Cevizci S, Dereköy FS. Correlation of voice and quality of life with adjuvant radiotherapy in patients with larynx cancer. Fam Pract Palliat Care. 2017;2:9–16.
MLA	Kara, Medine et al. “Correlation of Voice and Quality of Life With Adjuvant Radiotherapy in Patients With Larynx Cancer”. Family Practice and Palliative Care, vol. 2, no. 1, 2017, pp. 9-16, doi:10.22391/920.308837.
Vancouver	Kara M, Ertekin H, Şahin B, Cevizci S, Dereköy FS. Correlation of voice and quality of life with adjuvant radiotherapy in patients with larynx cancer. Fam Pract Palliat Care. 2017;2(1):9-16.