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Serum netrin-1 seviyesinin meme kitleleriyle ilişkisi

Year 2018, Volume 3, Issue 3, 123 - 126, 04.10.2018
https://doi.org/10.22391/fppc.467700

Abstract

Giriş: Netrin-1'in anjiyogenezi indüklediği ve proto-onkogen olarak işlev gördüğü gösterilmiştir. Serum netrin-1 düzeyinin meme kitlesi varlığı ve kitlenin yapısı ile ilişkisini değerlendirmeyi amaçladık.

Yöntem: Çalışmaya 27 benign kitlesi olan, 31 hasta malign kitlesi olan ve 26 sağlıklı kontrol olmak üzere toplam 84 hasta alındı.

Bulgular: Çalışmamızda malign kitlesi olan hastalarda ortalama netrin-1 düzeyi 479 ± 325 pg / ml, benign kitlesi olanlarda 336.9 ± 178.2 pg / ml ve sağlıklı kontrollerde 264.7 ± 112.4 pg / ml bulundu. Bu üç grup arasında ortalama serum netrin-1 seviyesinde istatistiksel olarak anlamlı bir fark vardı (p = 0.007). Çalışmaya katılan hastalar (benign ve malign gruplar) ve kontrol grubu olmak üzere iki gruba ayrıldığında, ortalama netrin-1 düzeyi kitlesi olmayanlarda ortalama 264.7 ± 112.4 pg / ml ve kitlesi olanlarda 412.8 ± 274.2 pg / ml. Kitle saptananların ortalama netrin-1 düzeyi kitle olmayanlara göre istatistiksel olarak anlamlı yüksek olduğu görüldü (p = 0.016).

Sonuç: Ortalama serum netrin-1 düzeyi, meme kitlesi olan, özellikle de malign kitle olan hastalarda anlamlı olarak daha yüksek bulundu.

References

  • World HO. World Health Organization Statistical Information System (WHOSIS). 2015.
  • Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer. 2015;136(5):E359-E86. https://doi.org/10.1002/ijc.29210
  • Rajasekharan S, Kennedy TE. The netrin protein family. Genome biology. 2009;10(9):239. https://doi.org/10.1186/gb-2009-10-9-239
  • Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 1996;87(6):1001-14. https://doi.org/10.1016/S0092-8674(00)81795-X
  • Mehlen P, Furne C. Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. Cellular and molecular life sciences. 2005;62(22):2599-616. https://doi.org/10.1007/s00018-005-5191-3
  • Barallobre MJ, Pascual M, Del Río JA, Soriano E. The Netrin family of guidance factors: emphasis on Netrin-1 signalling. Brain Research Reviews. 2005;49(1):22-47. https://doi.org/10.1016/j.brainresrev.2004.11.003
  • Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nature Reviews Cancer. 2004;4(12):978-87. https://doi.org/10.1038/nrc1504
  • Llambi F, Causeret F, Bloch‐Gallego E, Mehlen P. Netrin‐1 acts as a survival factor via its receptors UNC5H and DCC. The EMBO journal. 2001;20(11):2715-22. https://doi.org/10.1093/emboj/20.11.2715
  • Ramesh G, Berg A, Jayakumar C. Plasma netrin-1 is a diagnostic biomarker of human cancers. Biomarkers. 2011;16(2):172-80. https://doi.org/10.3109/1354750X.2010.541564
  • Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. The American journal of pathology. 1995;146(5):1029. https://www.ncbi.nlm.nih.gov/pubmed/7538264 Gong B-S, Feng Q. Netrin-1: the new tumor markers in renal clear cell carcinoma. Asian Pacific journal of tropical medicine. 2015;8(6):489-93. https://doi.org/10.1016/j.apjtm.2015.05.005
  • Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, et al. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell growth and differentiation. 1999;10:35-42. https://www.ncbi.nlm.nih.gov/pubmed/9950216
  • Fitamant J, Guenebeaud C, Coissieux M-M, Guix C, Treilleux I, Scoazec J-Y, et al. Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proceedings of the National Academy of Sciences. 2008;105(12):4850-5. https://doi.org/10.1073/pnas.0709810105
  • Delloye-Bourgeois C, Brambilla E, Coissieux M-M, Guenebeaud C, Pedeux R, Firlej V, et al. Interference with netrin-1 and tumor cell death in Non–small cell lung cancer. Journal of the National Cancer Institute. 2009. https://doi.org/10.1093/jnci/djn491
  • Dumartin L, Quemener C, Laklai H, Herbert J, Bicknell R, Bousquet C, et al. Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells. Gastroenterology. 2010;138(4):1595-606. e8. https://doi.org/10.1053/j.gastro.2009.12.061
  • Paradisi A, Maisse C, Coissieux M-M, Gadot N, Lépinasse F, Delloye-Bourgeois C, et al. Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proceedings of the National Academy of Sciences. 2009;106(40):17146-51. https://doi.org/10.1073/pnas.0901767106
  • Yıldırım ME, Kefeli U, Aydın D, Sener N, Gümüş M. The value of plasma netrin-1 in non-small cell lung cancer patients as diagnostic and prognostic biomarker. Tumor Biology. 2016;37(9):11903-7. https://doi.org/10.1007/s13277-016-5025-y

Relationship of serum netrin-1 levels with breast masses

Year 2018, Volume 3, Issue 3, 123 - 126, 04.10.2018
https://doi.org/10.22391/fppc.467700

Abstract

Introduction: Netrin-1 has been shown to induce angiogenesis and is considered to function as a proto-oncogene. We aimed to evaluate the relationship of serum netrin-1 level with the presence of breast mass and the nature of mass.

Methods: A total of 84 patients, including 27 patients with benign mass, 31 patients with malignant mass and 26 healthy controls, were enrolled in the study.

Results: In our study, the mean serum netrin-1 level was 479±325 pg/ml in the patients with malignant mass, 336.9±178.2 pg/ml in the patients with benign mass and 264.7±112.4 pg/ml in the healthy controls, respectively. There was a statistically significant difference in mean serum netrin-1 level between these three groups (p=0.007). When the patients participating in the study were divided in to two groups as those with (the benign and malign groups) and without (the control group) mass, the mean serum netrin-1 level was 264.7±112.4 pg/ml in those without mass and 412.8±274.2 pg/ml in those with mass, respectively. It was seen that the mean serum netrin-1 level of those with mass was statistically significantly higher than that of those without mass (p=0.016).

Conclusion: The mean serum netrin-1 level was found to be significantly higher in the patients with breast mass, especially those with malignant mass.

References

  • World HO. World Health Organization Statistical Information System (WHOSIS). 2015.
  • Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer. 2015;136(5):E359-E86. https://doi.org/10.1002/ijc.29210
  • Rajasekharan S, Kennedy TE. The netrin protein family. Genome biology. 2009;10(9):239. https://doi.org/10.1186/gb-2009-10-9-239
  • Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 1996;87(6):1001-14. https://doi.org/10.1016/S0092-8674(00)81795-X
  • Mehlen P, Furne C. Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. Cellular and molecular life sciences. 2005;62(22):2599-616. https://doi.org/10.1007/s00018-005-5191-3
  • Barallobre MJ, Pascual M, Del Río JA, Soriano E. The Netrin family of guidance factors: emphasis on Netrin-1 signalling. Brain Research Reviews. 2005;49(1):22-47. https://doi.org/10.1016/j.brainresrev.2004.11.003
  • Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nature Reviews Cancer. 2004;4(12):978-87. https://doi.org/10.1038/nrc1504
  • Llambi F, Causeret F, Bloch‐Gallego E, Mehlen P. Netrin‐1 acts as a survival factor via its receptors UNC5H and DCC. The EMBO journal. 2001;20(11):2715-22. https://doi.org/10.1093/emboj/20.11.2715
  • Ramesh G, Berg A, Jayakumar C. Plasma netrin-1 is a diagnostic biomarker of human cancers. Biomarkers. 2011;16(2):172-80. https://doi.org/10.3109/1354750X.2010.541564
  • Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. The American journal of pathology. 1995;146(5):1029. https://www.ncbi.nlm.nih.gov/pubmed/7538264 Gong B-S, Feng Q. Netrin-1: the new tumor markers in renal clear cell carcinoma. Asian Pacific journal of tropical medicine. 2015;8(6):489-93. https://doi.org/10.1016/j.apjtm.2015.05.005
  • Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, et al. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell growth and differentiation. 1999;10:35-42. https://www.ncbi.nlm.nih.gov/pubmed/9950216
  • Fitamant J, Guenebeaud C, Coissieux M-M, Guix C, Treilleux I, Scoazec J-Y, et al. Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proceedings of the National Academy of Sciences. 2008;105(12):4850-5. https://doi.org/10.1073/pnas.0709810105
  • Delloye-Bourgeois C, Brambilla E, Coissieux M-M, Guenebeaud C, Pedeux R, Firlej V, et al. Interference with netrin-1 and tumor cell death in Non–small cell lung cancer. Journal of the National Cancer Institute. 2009. https://doi.org/10.1093/jnci/djn491
  • Dumartin L, Quemener C, Laklai H, Herbert J, Bicknell R, Bousquet C, et al. Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells. Gastroenterology. 2010;138(4):1595-606. e8. https://doi.org/10.1053/j.gastro.2009.12.061
  • Paradisi A, Maisse C, Coissieux M-M, Gadot N, Lépinasse F, Delloye-Bourgeois C, et al. Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proceedings of the National Academy of Sciences. 2009;106(40):17146-51. https://doi.org/10.1073/pnas.0901767106
  • Yıldırım ME, Kefeli U, Aydın D, Sener N, Gümüş M. The value of plasma netrin-1 in non-small cell lung cancer patients as diagnostic and prognostic biomarker. Tumor Biology. 2016;37(9):11903-7. https://doi.org/10.1007/s13277-016-5025-y

Details

Primary Language English
Subjects Health Care Sciences and Services
Published Date Dec 2018
Journal Section Original Research
Authors

İbrahim SOLAK (Primary Author)
University of Health Sciences, Training and Research Hospital, Department of Family Medicine, Konya
0000-0001-5311-0631
Türkiye


Duygu İlke YİLDİRİM This is me
University of Health Sciences, Training and Research Hospital, Department of Family Medicine, Konya
0000-0002-3893-5173
Türkiye


Mustafa SOLAK This is me
Hisar Intercontinental Hospital, Department of Oncology, Istanbul
0000-0001-7939-7781
Türkiye


Cigdem Damla CETİNKAYA This is me
University of Health Sciences, Training and Research Hospital, Department of Biochemistry, Konya
0000-0002-6052-4645
Türkiye


Ayse BOYACİ This is me
University of Health Sciences, Training and Research Hospital, Department of General Surgery, Konya
0000-0002-9191-7687
Türkiye


Mehmet Ali ERYİLMAZ This is me
University of Health Sciences, Training and Research Hospital, Department of General Surgery, Konya
0000-0002-5280-3943
Türkiye

Publication Date October 4, 2018
Application Date October 5, 2018
Acceptance Date October 16, 2018
Published in Issue Year 2018, Volume 3, Issue 3

Cite

Bibtex @research article { fppc467700, journal = {Family Practice and Palliative Care}, issn = {2458-8865}, eissn = {2459-1505}, address = {}, publisher = {Yusuf Haydar ERTEKİN}, year = {2018}, volume = {3}, pages = {123 - 126}, doi = {10.22391/fppc.467700}, title = {Relationship of serum netrin-1 levels with breast masses}, key = {cite}, author = {Solak, İbrahim and Yildirim, Duygu İlke and Solak, Mustafa and Cetinkaya, Cigdem Damla and Boyaci, Ayse and Eryilmaz, Mehmet Ali} }
APA Solak, İ. , Yildirim, D. İ. , Solak, M. , Cetinkaya, C. D. , Boyaci, A. & Eryilmaz, M. A. (2018). Relationship of serum netrin-1 levels with breast masses . Family Practice and Palliative Care , 3 (3) , 123-126 . DOI: 10.22391/fppc.467700
MLA Solak, İ. , Yildirim, D. İ. , Solak, M. , Cetinkaya, C. D. , Boyaci, A. , Eryilmaz, M. A. "Relationship of serum netrin-1 levels with breast masses" . Family Practice and Palliative Care 3 (2018 ): 123-126 <http://www.fppc.com.tr/en/pub/issue/39527/467700>
Chicago Solak, İ. , Yildirim, D. İ. , Solak, M. , Cetinkaya, C. D. , Boyaci, A. , Eryilmaz, M. A. "Relationship of serum netrin-1 levels with breast masses". Family Practice and Palliative Care 3 (2018 ): 123-126
RIS TY - JOUR T1 - Relationship of serum netrin-1 levels with breast masses AU - İbrahim Solak , Duygu İlke Yildirim , Mustafa Solak , Cigdem Damla Cetinkaya , Ayse Boyaci , Mehmet Ali Eryilmaz Y1 - 2018 PY - 2018 N1 - doi: 10.22391/fppc.467700 DO - 10.22391/fppc.467700 T2 - Family Practice and Palliative Care JF - Journal JO - JOR SP - 123 EP - 126 VL - 3 IS - 3 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.467700 UR - https://doi.org/10.22391/fppc.467700 Y2 - 2018 ER -
EndNote %0 Family Practice and Palliative Care Relationship of serum netrin-1 levels with breast masses %A İbrahim Solak , Duygu İlke Yildirim , Mustafa Solak , Cigdem Damla Cetinkaya , Ayse Boyaci , Mehmet Ali Eryilmaz %T Relationship of serum netrin-1 levels with breast masses %D 2018 %J Family Practice and Palliative Care %P 2458-8865-2459-1505 %V 3 %N 3 %R doi: 10.22391/fppc.467700 %U 10.22391/fppc.467700
ISNAD Solak, İbrahim , Yildirim, Duygu İlke , Solak, Mustafa , Cetinkaya, Cigdem Damla , Boyaci, Ayse , Eryilmaz, Mehmet Ali . "Relationship of serum netrin-1 levels with breast masses". Family Practice and Palliative Care 3 / 3 (October 2018): 123-126 . https://doi.org/10.22391/fppc.467700
AMA Solak İ. , Yildirim D. İ. , Solak M. , Cetinkaya C. D. , Boyaci A. , Eryilmaz M. A. Relationship of serum netrin-1 levels with breast masses. Fam Pract Palliat Care. 2018; 3(3): 123-126.
Vancouver Solak İ. , Yildirim D. İ. , Solak M. , Cetinkaya C. D. , Boyaci A. , Eryilmaz M. A. Relationship of serum netrin-1 levels with breast masses. Family Practice and Palliative Care. 2018; 3(3): 123-126.
IEEE İ. Solak , D. İ. Yildirim , M. Solak , C. D. Cetinkaya , A. Boyaci and M. A. Eryilmaz , "Relationship of serum netrin-1 levels with breast masses", Family Practice and Palliative Care, vol. 3, no. 3, pp. 123-126, Oct. 2018, doi:10.22391/fppc.467700

Family Practice and Palliative Care       ISSN 2458-8865       E-ISSN 2459-1505

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