Family Practice and Palliative Care
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Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss

Year 2018, Volume 3, Issue 3, 133 - 138, 04.10.2018

İbrahim SOLAK Abdullah ARSLAN Ruhusen KUTLU Betul KOZANHAN Salim NESELİOGLU Ozcan EREL Cigdem Damla CETİNKAYA Mehmet Ali ERYİLMAZ

https://doi.org/10.22391/fppc.470360

Abstract

Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency that can lead to loss of function in one of the most important human senses. Recently, hyperbaric oxygen therapy (HBOT) has gained popularity with pharmacotherapy in ISSNHL. This study aimed to determine changes induced in thiol/disulfide homeostasis (TDH, a new biomarker of systemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL.

Methods: This prospective study analyzed the albumin, total thiol, native thiol, and disulfide levels and disulfide-native thiol, disulfide-total thiol, and native thiol-total thiol ratios before and after HBOT with standardizing pharmacotherapy using a new colorimetric method in patients with ISSNHL.

Results: 41 patients with ISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study. The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) had hearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear. There was a statistically significant decrease in the albumin (p<0.001), total thiol (p<0.001), native thiol (p<0.001), and disulfide (p<0.001) levels after treatment compared to baseline. There was no statistically significant difference in the disulfide-native thiol (p=0.148), disulfide-total thiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatment compared to baseline.

Conclusion: Consequently, this study demonstrated that the thiol-disulphide balance tended to shift towards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL and that patients with high oxidation level after treatment had better treatment response.

Keywords

Idiopathic sudden sensorineural hearing loss, oxidative stress, thiol/disulfide homeostasis, hyperbaric oxygen therapy

References

  • 1. Stachler RJ, Chandrasekhar SS, Archer SM, et al. Clinical practice guideline: sudden hearing loss. Otolaryngology—Head and Neck Surgery. 2012;146(3_suppl):S1-S35. doi: https://doi.org/10.1177/0194599812436449
  • 2. Chin CJ, Kathryn Dorman MSc M. Sudden sensorineural hearing loss. CMAJ. 2017;189(11):E437. doi: https://doi.org/10.1503/cmaj.161191
  • 3. Seidman MD, Vivek P. Intratympanic treatment of hearing loss with novel and traditional agents. Otolaryngol Clin N Am. 2004;37(5):973-90. doi: https://doi.org/10.1016/j.otc.2004.03.005
  • 4. Devarajan P, Savoca M, Castaneda MP, et al. Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways. Hearing research. 2002;174(1-2):45-54. doi: https://doi.org/10.1016/S0378-5955(02)00634-2
  • 5. Ciorba A, Gasparini P, Chicca M, et al. Reactive oxygen species in human inner ear perilymph. Acta oto-laryngologica. 2010;130(2):240-6. doi: https://doi.org/10.3109/00016480903143978
  • 6. Henderson D, Bielefeld EC, Harris KC, et al. The role of oxidative stress in noise-induced hearing loss. Ear and Hearing.. 2006;27(1):1-19. doi: https://doi.org/10.1097/01.aud.0000191942.36672.f3
  • 7. Labbé D, Teranishi M-a, Hess A, et al. Activation of caspase-3 is associated with oxidative stress in the hydropic guinea pig cochlea. Hearing research. 2005;202(1-2):21-7. doi: https://doi.org/10.1016/j.heares.2004.10.002
  • 8. Singh R, Wangemann P. Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model. Am J Physiol Renal Physiol. 2008;294(1):F139-F48. doi: https://doi.org/10.1152/ajprenal.00433.2007
  • 9. Antunes de Souza Chelminski Barreto M, Lima Losno Ledesma A, Costa Pires de Oliveira CA, et al. Intratympanic corticosteroid for sudden hearing loss: does it really work? Braz J Otorhinolaryngol. 2016;82(3). doi: https://doi.org/10.1016/j.bjorl.2015.06.007
  • 10. Paprocki J, Gackowska M, Pawłowska M, et al. The current use of hyperbaric oxygen treatment. Medycyna Rodzinna. 2016.
  • 11. Paprocki J, Pawłowska M, Sutkowy P, et al. The Oxidant–Antioxidant Equilibrium in the Blood of People with Sudden Sensorineural Hearing Loss After the First Hyperbaric Oxygen Therapy Session–A Preliminary Study. Polish Hyperbaric Research. 2017;61(4):15-24. doi: https://doi.org/10.1515/phr-2017-0018
  • 12. Solak I, Cetinkaya C, Gederet Y, et al. Effects of smoking on thiol/disulfide homeostasis. Eur Rev Med Pharmacol Sci. 2017;21:2477-82. doi: https://doi.org/10.26355/eurrev_201804_14842
  • 13. Cadenas E. Biochemistry of oxygen toxicity. Annu. Rev. Biochem. 1989;58(1):79-110. doi: https://doi.org/10.1146/annurev.bi.58.070189.000455
  • 14. Young I, Woodside J. Antioxidants in health and disease. Journal of clinical pathology. 2001;54(3):176-86. doi: https://doi.org/10.1136/jcp.54.3.176
  • 15. Biswas S, Chida AS, Rahman I. Redox modifications of protein–thiols: emerging roles in cell signaling. Biochemical pharmacology. 2006;71(5):551-64. doi: https://doi.org/10.1016/j.bcp.2005.10.044
  • 16. Prabhu A, Sarcar B, Kahali S, et al. Cysteine catabolism: a novel metabolic pathway contributing to glioblastoma growth. Cancer research. 2014;74(3):787-96. doi: https://doi.org/10.1158/0008-5472.CAN-13-1423
  • 17. WHO – World Health Organization. Grades of Hearing impairment 2007 [acesso em 26 de fevereiro de 2010] Disponível em: http://www.who.int/pbd/desfness/hearing_impairment_grades/en/index.html
  • 18. Gul F, Muderris T, Yalciner G, et al. A comprehensive study of oxidative stress in sudden hearing loss. Eur Arch Otorhinolaryngol. 2017;274(3):1301-8. doi: https://doi.org/10.1007/s00405-016-4301-1
  • 19. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical biochemistry. 2014;47(18):326-32. doi: https://doi.org/10.1016/j.clinbiochem.2014.09.026
  • 20. Thanan R, Oikawa S, Hiraku Y, et al. Oxidative stress and its significant roles in neurodegenerative diseases and cancer. Int. J. Mol. Sci. 2014;16(1):193-217. doi: https://doi.org/10.3390/ijms16010193
  • 21. Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radical Biology and Medicine. 2013;65:244-53. doi: https://doi.org/10.1016/j.freeradbiomed.2013.05.050
  • 22. Jones DP, Liang Y. Measuring the poise of thiol/disulfide couples in vivo. Free Radical Biology and Medicine. 2009;47(10):1329-38. doi: https://doi.org/10.1016/j.freeradbiomed.2009.08.021
  • 23. Quaranta N, De Ceglie V, D’Elia A. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review. Audiology research. 2016;6(1). doi: https://doi.org/10.4081/audiores.2016.151
  • 24. Aslan I, Oysu C, Veyseller B, et al. Does the addition of hyperbaric oxygen therapy to the conventional treatment modalities influence the outcome of sudden deafness? Otolaryngology—Head and Neck Surgery. 2002;126(2):121-6. doi: https://doi.org/10.1067/mhn.2002.121915
  • 25. Topuz E, Yigit O, Cinar U, et al. Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss? Eur Arch Oto Rhino Laryngol and Head & Neck. 2004;261(7):393-6. doi: https://doi.org/10.1007/s00405-003-0688-6
  • 26. Cavaleriu BD, Mârţu DV, Hriţcu L, et al. Idiopathic sudden hearing loss: Oxidative status before and after corticoid treatment. Arch. Biol. Sci. 2015;67(4):1297-302. doi: https://doi.org/10.2298/ABS150909106C
  • 27. Ohno K, Noguchi Y, Kawashima Y, et al. Secondary hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss in the subacute and chronic phases. J Med Dent Sci. 2010;57(2):127-32. doi: https://doi.org/10.11480/jmds.570201
  • 28. Khater A, El-Anwar MW, Nofal AA-F, et al. Sudden Sensorineural Hearing Loss: Comparative Study of Different Treatment Modalities. Int Arch Otorhinolaryngol. 2018;22:245–249. doi: https://doi.org/10.1055/s-0037-1605376

İdiopatik ani işitme kaybı olan hastaların tiyol/disülfit homeostazisi üzerine hiperbarik oksijen tedavisinin etkisi

Year 2018, Volume 3, Issue 3, 133 - 138, 04.10.2018

İbrahim SOLAK Abdullah ARSLAN Ruhusen KUTLU Betul KOZANHAN Salim NESELİOGLU Ozcan EREL Cigdem Damla CETİNKAYA Mehmet Ali ERYİLMAZ

https://doi.org/10.22391/fppc.470360

Abstract

Giriş: İdyopatik ani sensorinöral işitme kaybı (ISSNHL) en önemli insan duyularından birinin işlev kaybına neden olabilen otolojik acil bir durumdur. Son zamanlarda ISSNHL’ nda hiperbarik oksijen tedavisi (HBOT), farmakoterapi ile birlikte popülerlik kazanmaktadır. Bu çalışmada ISSNHL olan hastalarda farmakoterapi ile HBOT’nin sistemik oksidatif stresin yeni bir göstergesi olan tiyol/disülfit homeostrazisinde (TDH) meydana getirdiği değişikliklerin tespiti amaçlandı.

Yöntem: Bu prospektif çalışmada ISSNHL olan hastalarda, çalışma başında ve standart tedaviyle birlikte HBOT uygulandıktan sonra albümin, total tiyol, native tiyol, disülfit düzeyleri ile disülfit /native tiyol, disülfit /total tiyol ve native tiyol/total tiyol oranları yeni bir kolorimetrik yöntem kullanılarak analiz edilmiştir.

Bulgular: Çalışmaya 14’ü (%34,1) kadın 27’si (%65,9) erkek olmak üzere 41 ISSNH’ li hasta katıldı. Hastaların yaş ortalaması 48,02±13,10 idi. Hastaların 24’ü (%58,5) sağ kulaktan 17’si (%41,5) sol kulaktan şikayeti vardı. Hastaların başlangıca göre tedavi sonrasında native tiyol (p<0,001), total tiyol (p<0,001), disülfit  (p<0,001) ve albümin (p<0,001) değerlerinde istatistiksel olarak anlamlı düşme olmuştur. Disülfit /native tiyol (p=0,148), disülfit /total tiyol (p=0,172) ve native tiyol/total tiyol (p=0,169) oranlarında tedavi sonrasında öncesine göre istatistiki olarak anlamlı fark bulunamamıştır.

Sonuç: Sonuç olarak bu çalışmada, ISSNHL hastalarda başlangıca göre HBOT ve medikal tedavi verildikten sonra tiyol-disülfit dengesinin oksidasyon yönüne doğru kayma eğiliminde olduğu ve tedavi sonrası oksidasyonun yüksek olduğu hastalarda tedaviye cevabın daha iyi olduğu görülmektedir.

Keywords

İdiopatik ani sensorinöral işitme kaybı, hiperbarik oksijen tedavisi, oksidatif stres, tiyol/disülfit homeostazisi, hiperbarik oksijen tedavisi

References

  • 1. Stachler RJ, Chandrasekhar SS, Archer SM, et al. Clinical practice guideline: sudden hearing loss. Otolaryngology—Head and Neck Surgery. 2012;146(3_suppl):S1-S35. doi: https://doi.org/10.1177/0194599812436449
  • 2. Chin CJ, Kathryn Dorman MSc M. Sudden sensorineural hearing loss. CMAJ. 2017;189(11):E437. doi: https://doi.org/10.1503/cmaj.161191
  • 3. Seidman MD, Vivek P. Intratympanic treatment of hearing loss with novel and traditional agents. Otolaryngol Clin N Am. 2004;37(5):973-90. doi: https://doi.org/10.1016/j.otc.2004.03.005
  • 4. Devarajan P, Savoca M, Castaneda MP, et al. Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways. Hearing research. 2002;174(1-2):45-54. doi: https://doi.org/10.1016/S0378-5955(02)00634-2
  • 5. Ciorba A, Gasparini P, Chicca M, et al. Reactive oxygen species in human inner ear perilymph. Acta oto-laryngologica. 2010;130(2):240-6. doi: https://doi.org/10.3109/00016480903143978
  • 6. Henderson D, Bielefeld EC, Harris KC, et al. The role of oxidative stress in noise-induced hearing loss. Ear and Hearing.. 2006;27(1):1-19. doi: https://doi.org/10.1097/01.aud.0000191942.36672.f3
  • 7. Labbé D, Teranishi M-a, Hess A, et al. Activation of caspase-3 is associated with oxidative stress in the hydropic guinea pig cochlea. Hearing research. 2005;202(1-2):21-7. doi: https://doi.org/10.1016/j.heares.2004.10.002
  • 8. Singh R, Wangemann P. Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model. Am J Physiol Renal Physiol. 2008;294(1):F139-F48. doi: https://doi.org/10.1152/ajprenal.00433.2007
  • 9. Antunes de Souza Chelminski Barreto M, Lima Losno Ledesma A, Costa Pires de Oliveira CA, et al. Intratympanic corticosteroid for sudden hearing loss: does it really work? Braz J Otorhinolaryngol. 2016;82(3). doi: https://doi.org/10.1016/j.bjorl.2015.06.007
  • 10. Paprocki J, Gackowska M, Pawłowska M, et al. The current use of hyperbaric oxygen treatment. Medycyna Rodzinna. 2016.
  • 11. Paprocki J, Pawłowska M, Sutkowy P, et al. The Oxidant–Antioxidant Equilibrium in the Blood of People with Sudden Sensorineural Hearing Loss After the First Hyperbaric Oxygen Therapy Session–A Preliminary Study. Polish Hyperbaric Research. 2017;61(4):15-24. doi: https://doi.org/10.1515/phr-2017-0018
  • 12. Solak I, Cetinkaya C, Gederet Y, et al. Effects of smoking on thiol/disulfide homeostasis. Eur Rev Med Pharmacol Sci. 2017;21:2477-82. doi: https://doi.org/10.26355/eurrev_201804_14842
  • 13. Cadenas E. Biochemistry of oxygen toxicity. Annu. Rev. Biochem. 1989;58(1):79-110. doi: https://doi.org/10.1146/annurev.bi.58.070189.000455
  • 14. Young I, Woodside J. Antioxidants in health and disease. Journal of clinical pathology. 2001;54(3):176-86. doi: https://doi.org/10.1136/jcp.54.3.176
  • 15. Biswas S, Chida AS, Rahman I. Redox modifications of protein–thiols: emerging roles in cell signaling. Biochemical pharmacology. 2006;71(5):551-64. doi: https://doi.org/10.1016/j.bcp.2005.10.044
  • 16. Prabhu A, Sarcar B, Kahali S, et al. Cysteine catabolism: a novel metabolic pathway contributing to glioblastoma growth. Cancer research. 2014;74(3):787-96. doi: https://doi.org/10.1158/0008-5472.CAN-13-1423
  • 17. WHO – World Health Organization. Grades of Hearing impairment 2007 [acesso em 26 de fevereiro de 2010] Disponível em: http://www.who.int/pbd/desfness/hearing_impairment_grades/en/index.html
  • 18. Gul F, Muderris T, Yalciner G, et al. A comprehensive study of oxidative stress in sudden hearing loss. Eur Arch Otorhinolaryngol. 2017;274(3):1301-8. doi: https://doi.org/10.1007/s00405-016-4301-1
  • 19. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical biochemistry. 2014;47(18):326-32. doi: https://doi.org/10.1016/j.clinbiochem.2014.09.026
  • 20. Thanan R, Oikawa S, Hiraku Y, et al. Oxidative stress and its significant roles in neurodegenerative diseases and cancer. Int. J. Mol. Sci. 2014;16(1):193-217. doi: https://doi.org/10.3390/ijms16010193
  • 21. Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radical Biology and Medicine. 2013;65:244-53. doi: https://doi.org/10.1016/j.freeradbiomed.2013.05.050
  • 22. Jones DP, Liang Y. Measuring the poise of thiol/disulfide couples in vivo. Free Radical Biology and Medicine. 2009;47(10):1329-38. doi: https://doi.org/10.1016/j.freeradbiomed.2009.08.021
  • 23. Quaranta N, De Ceglie V, D’Elia A. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review. Audiology research. 2016;6(1). doi: https://doi.org/10.4081/audiores.2016.151
  • 24. Aslan I, Oysu C, Veyseller B, et al. Does the addition of hyperbaric oxygen therapy to the conventional treatment modalities influence the outcome of sudden deafness? Otolaryngology—Head and Neck Surgery. 2002;126(2):121-6. doi: https://doi.org/10.1067/mhn.2002.121915
  • 25. Topuz E, Yigit O, Cinar U, et al. Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss? Eur Arch Oto Rhino Laryngol and Head & Neck. 2004;261(7):393-6. doi: https://doi.org/10.1007/s00405-003-0688-6
  • 26. Cavaleriu BD, Mârţu DV, Hriţcu L, et al. Idiopathic sudden hearing loss: Oxidative status before and after corticoid treatment. Arch. Biol. Sci. 2015;67(4):1297-302. doi: https://doi.org/10.2298/ABS150909106C
  • 27. Ohno K, Noguchi Y, Kawashima Y, et al. Secondary hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss in the subacute and chronic phases. J Med Dent Sci. 2010;57(2):127-32. doi: https://doi.org/10.11480/jmds.570201
  • 28. Khater A, El-Anwar MW, Nofal AA-F, et al. Sudden Sensorineural Hearing Loss: Comparative Study of Different Treatment Modalities. Int Arch Otorhinolaryngol. 2018;22:245–249. doi: https://doi.org/10.1055/s-0037-1605376

Details

Primary Language English
Subjects Health Care Sciences and Services
Published Date Dec 2018
Journal Section Original Research
Authors

İbrahim SOLAK (Primary Author)
University of Health Sciences, Training and Research Hospital, Department of Family Medicine, Konya
0000-0001-5311-0631
Türkiye

Abdullah ARSLAN
University of Health Sciences, Training and Research Hospital, Department of Underwater and Hyperbaric, Konya
0000-0001-5575-326X
Türkiye

Ruhusen KUTLU
Necmettin Erbakan University, School of Medicine, Department of Family Medicine, Konya
0000-0002-8502-0232
Türkiye

Betul KOZANHAN
University of Health Sciences, Training and Research Hospital, Department of Anesthesiology, Konya
0000-0002-5097-9291
Türkiye

Salim NESELİOGLU This is me
Yildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Department of Biochemistry, Ankara
0000-0001-7571-5949
Türkiye

Ozcan EREL This is me
Yildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Department of Biochemistry, Ankara
0000-0002-2483-1939
Türkiye

Cigdem Damla CETİNKAYA This is me
University of Health Sciences, Training and Research Hospital, Department of Biochemistry, Konya
0000-0002-6052-4645
Türkiye

Mehmet Ali ERYİLMAZ This is me
University of Health Sciences, Training and Research Hospital, Department of General Surgery, Konya
0000-0002-5280-3943
Türkiye

Publication Date October 4, 2018
Application Date October 14, 2018
Acceptance Date October 22, 2018
Published in Issue Year 2018, Volume 3, Issue 3

Cite

Bibtex @research article { fppc470360, journal = {Family Practice and Palliative Care}, issn = {2458-8865}, eissn = {2459-1505}, address = {}, publisher = {Yusuf Haydar ERTEKİN}, year = {2018}, volume = {3}, number = {3}, pages = {133 - 138}, doi = {10.22391/fppc.470360}, title = {Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss}, key = {cite}, author = {Solak, İbrahim and Arslan, Abdullah and Kutlu, Ruhusen and Kozanhan, Betul and Neselioglu, Salim and Erel, Ozcan and Cetinkaya, Cigdem Damla and Eryilmaz, Mehmet Ali} }
APA Solak, İ. , Arslan, A. , Kutlu, R. , Kozanhan, B. , Neselioglu, S. , Erel, O. , Cetinkaya, C. D. & Eryilmaz, M. A. (2018). Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss . Family Practice and Palliative Care , 3 (3) , 133-138 . DOI: 10.22391/fppc.470360
MLA Solak, İ. , Arslan, A. , Kutlu, R. , Kozanhan, B. , Neselioglu, S. , Erel, O. , Cetinkaya, C. D. , Eryilmaz, M. A. "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss" . Family Practice and Palliative Care 3 (2018 ): 133-138 <http://www.fppc.com.tr/en/pub/issue/39527/470360>
Chicago Solak, İ. , Arslan, A. , Kutlu, R. , Kozanhan, B. , Neselioglu, S. , Erel, O. , Cetinkaya, C. D. , Eryilmaz, M. A. "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss". Family Practice and Palliative Care 3 (2018 ): 133-138
RIS TY - JOUR T1 - Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss AU - İbrahim Solak , Abdullah Arslan , Ruhusen Kutlu , Betul Kozanhan , Salim Neselioglu , Ozcan Erel , Cigdem Damla Cetinkaya , Mehmet Ali Eryilmaz Y1 - 2018 PY - 2018 N1 - doi: 10.22391/fppc.470360 DO - 10.22391/fppc.470360 T2 - Family Practice and Palliative Care JF - Journal JO - JOR SP - 133 EP - 138 VL - 3 IS - 3 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.470360 UR - https://doi.org/10.22391/fppc.470360 Y2 - 2018 ER -
EndNote %0 Family Practice and Palliative Care Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss %A İbrahim Solak , Abdullah Arslan , Ruhusen Kutlu , Betul Kozanhan , Salim Neselioglu , Ozcan Erel , Cigdem Damla Cetinkaya , Mehmet Ali Eryilmaz %T Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss %D 2018 %J Family Practice and Palliative Care %P 2458-8865-2459-1505 %V 3 %N 3 %R doi: 10.22391/fppc.470360 %U 10.22391/fppc.470360
ISNAD Solak, İbrahim , Arslan, Abdullah , Kutlu, Ruhusen , Kozanhan, Betul , Neselioglu, Salim , Erel, Ozcan , Cetinkaya, Cigdem Damla , Eryilmaz, Mehmet Ali . "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss". Family Practice and Palliative Care 3 / 3 (October 2018): 133-138 . https://doi.org/10.22391/fppc.470360
AMA Solak İ. , Arslan A. , Kutlu R. , Kozanhan B. , Neselioglu S. , Erel O. , Cetinkaya C. D. , Eryilmaz M. A. Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. Fam Pract Palliat Care. 2018; 3(3): 133-138.
Vancouver Solak İ. , Arslan A. , Kutlu R. , Kozanhan B. , Neselioglu S. , Erel O. , Cetinkaya C. D. , Eryilmaz M. A. Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. Family Practice and Palliative Care. 2018; 3(3): 133-138.
IEEE İ. Solak , A. Arslan , R. Kutlu , B. Kozanhan , S. Neselioglu , O. Erel , C. D. Cetinkaya and M. A. Eryilmaz , "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss", Family Practice and Palliative Care, vol. 3, no. 3, pp. 133-138, Oct. 2018, doi:10.22391/fppc.470360
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Family Practice and Palliative Care       ISSN 2458-8865       E-ISSN 2459-1505

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