Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency that can lead to loss of function in one of the most important human senses. Recently, hyperbaric oxygen therapy (HBOT) has gained popularity with pharmacotherapy in ISSNHL. This study aimed to determine changes induced in thiol/disulfide homeostasis (TDH, a new biomarker of systemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL.
Methods: This prospective study analyzed the albumin, total thiol, native thiol, and disulfide levels and disulfide-native thiol, disulfide-total thiol, and native thiol-total thiol ratios before and after HBOT with standardizing pharmacotherapy using a new colorimetric method in patients with ISSNHL.
Results: 41 patients with ISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study. The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) had hearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear. There was a statistically significant decrease in the albumin (p<0.001), total thiol (p<0.001), native thiol (p<0.001), and disulfide (p<0.001) levels after treatment compared to baseline. There was no statistically significant difference in the disulfide-native thiol (p=0.148), disulfide-total thiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatment compared to baseline.
Conclusion: Consequently, this study demonstrated that the thiol-disulphide balance tended to shift towards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL and that patients with high oxidation level after treatment had better treatment response.
Idiopathic sudden sensorineural hearing loss, oxidative stress, thiol/disulfide homeostasis, hyperbaric oxygen therapy
Giriş: İdyopatik ani sensorinöral işitme kaybı (ISSNHL) en önemli insan duyularından birinin işlev kaybına neden olabilen otolojik acil bir durumdur. Son zamanlarda ISSNHL’ nda hiperbarik oksijen tedavisi (HBOT), farmakoterapi ile birlikte popülerlik kazanmaktadır. Bu çalışmada ISSNHL olan hastalarda farmakoterapi ile HBOT’nin sistemik oksidatif stresin yeni bir göstergesi olan tiyol/disülfit homeostrazisinde (TDH) meydana getirdiği değişikliklerin tespiti amaçlandı.
Yöntem: Bu prospektif çalışmada ISSNHL olan hastalarda, çalışma başında ve standart tedaviyle birlikte HBOT uygulandıktan sonra albümin, total tiyol, native tiyol, disülfit düzeyleri ile disülfit /native tiyol, disülfit /total tiyol ve native tiyol/total tiyol oranları yeni bir kolorimetrik yöntem kullanılarak analiz edilmiştir.
Bulgular: Çalışmaya 14’ü (%34,1) kadın 27’si (%65,9) erkek olmak üzere 41 ISSNH’ li hasta katıldı. Hastaların yaş ortalaması 48,02±13,10 idi. Hastaların 24’ü (%58,5) sağ kulaktan 17’si (%41,5) sol kulaktan şikayeti vardı. Hastaların başlangıca göre tedavi sonrasında native tiyol (p<0,001), total tiyol (p<0,001), disülfit (p<0,001) ve albümin (p<0,001) değerlerinde istatistiksel olarak anlamlı düşme olmuştur. Disülfit /native tiyol (p=0,148), disülfit /total tiyol (p=0,172) ve native tiyol/total tiyol (p=0,169) oranlarında tedavi sonrasında öncesine göre istatistiki olarak anlamlı fark bulunamamıştır.
Sonuç: Sonuç olarak bu çalışmada, ISSNHL hastalarda başlangıca göre HBOT ve medikal tedavi verildikten sonra tiyol-disülfit dengesinin oksidasyon yönüne doğru kayma eğiliminde olduğu ve tedavi sonrası oksidasyonun yüksek olduğu hastalarda tedaviye cevabın daha iyi olduğu görülmektedir.
İdiopatik ani sensorinöral işitme kaybı, hiperbarik oksijen tedavisi, oksidatif stres, tiyol/disülfit homeostazisi, hiperbarik oksijen tedavisi
Primary Language | English |
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Subjects | Health Care Sciences and Services |
Published Date | Dec 2018 |
Journal Section | Original Research |
Authors |
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Publication Date | October 4, 2018 |
Application Date | October 14, 2018 |
Acceptance Date | October 22, 2018 |
Published in Issue | Year 2018, Volume 3, Issue 3 |
Bibtex | @research article { fppc470360, journal = {Family Practice and Palliative Care}, issn = {2458-8865}, eissn = {2459-1505}, address = {}, publisher = {Yusuf Haydar ERTEKİN}, year = {2018}, volume = {3}, pages = {133 - 138}, doi = {10.22391/fppc.470360}, title = {Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss}, key = {cite}, author = {Solak, İbrahim and Arslan, Abdullah and Kutlu, Ruhusen and Kozanhan, Betul and Neselioglu, Salim and Erel, Ozcan and Cetinkaya, Cigdem Damla and Eryilmaz, Mehmet Ali} } |
APA | Solak, İ. , Arslan, A. , Kutlu, R. , Kozanhan, B. , Neselioglu, S. , Erel, O. , Cetinkaya, C. D. & Eryilmaz, M. A. (2018). Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss . Family Practice and Palliative Care , 3 (3) , 133-138 . DOI: 10.22391/fppc.470360 |
MLA | Solak, İ. , Arslan, A. , Kutlu, R. , Kozanhan, B. , Neselioglu, S. , Erel, O. , Cetinkaya, C. D. , Eryilmaz, M. A. "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss" . Family Practice and Palliative Care 3 (2018 ): 133-138 <http://www.fppc.com.tr/en/pub/issue/39527/470360> |
Chicago | Solak, İ. , Arslan, A. , Kutlu, R. , Kozanhan, B. , Neselioglu, S. , Erel, O. , Cetinkaya, C. D. , Eryilmaz, M. A. "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss". Family Practice and Palliative Care 3 (2018 ): 133-138 |
RIS | TY - JOUR T1 - Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss AU - İbrahim Solak , Abdullah Arslan , Ruhusen Kutlu , Betul Kozanhan , Salim Neselioglu , Ozcan Erel , Cigdem Damla Cetinkaya , Mehmet Ali Eryilmaz Y1 - 2018 PY - 2018 N1 - doi: 10.22391/fppc.470360 DO - 10.22391/fppc.470360 T2 - Family Practice and Palliative Care JF - Journal JO - JOR SP - 133 EP - 138 VL - 3 IS - 3 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.470360 UR - https://doi.org/10.22391/fppc.470360 Y2 - 2018 ER - |
EndNote | %0 Family Practice and Palliative Care Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss %A İbrahim Solak , Abdullah Arslan , Ruhusen Kutlu , Betul Kozanhan , Salim Neselioglu , Ozcan Erel , Cigdem Damla Cetinkaya , Mehmet Ali Eryilmaz %T Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss %D 2018 %J Family Practice and Palliative Care %P 2458-8865-2459-1505 %V 3 %N 3 %R doi: 10.22391/fppc.470360 %U 10.22391/fppc.470360 |
ISNAD | Solak, İbrahim , Arslan, Abdullah , Kutlu, Ruhusen , Kozanhan, Betul , Neselioglu, Salim , Erel, Ozcan , Cetinkaya, Cigdem Damla , Eryilmaz, Mehmet Ali . "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss". Family Practice and Palliative Care 3 / 3 (October 2018): 133-138 . https://doi.org/10.22391/fppc.470360 |
AMA | Solak İ. , Arslan A. , Kutlu R. , Kozanhan B. , Neselioglu S. , Erel O. , Cetinkaya C. D. , Eryilmaz M. A. Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. Fam Pract Palliat Care. 2018; 3(3): 133-138. |
Vancouver | Solak İ. , Arslan A. , Kutlu R. , Kozanhan B. , Neselioglu S. , Erel O. , Cetinkaya C. D. , Eryilmaz M. A. Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. Family Practice and Palliative Care. 2018; 3(3): 133-138. |
IEEE | İ. Solak , A. Arslan , R. Kutlu , B. Kozanhan , S. Neselioglu , O. Erel , C. D. Cetinkaya and M. A. Eryilmaz , "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss", Family Practice and Palliative Care, vol. 3, no. 3, pp. 133-138, Oct. 2018, doi:10.22391/fppc.470360 |