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Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss

Year 2018, Volume: 3 Issue: 3, 133 - 138, 04.10.2018

İbrahim Solak , Abdullah Arslan , Ruhusen Kutlu , Betul Kozanhan , Salim Neselioglu Ozcan Erel Cigdem Damla Cetinkaya Mehmet Ali Eryilmaz

https://doi.org/10.22391/fppc.470360

Abstract

Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is
an otologic emergency that can lead to loss of function in one of the most
important human senses. Recently, hyperbaric oxygen therapy (HBOT) has gained
popularity with pharmacotherapy in ISSNHL. This study aimed to determine
changes induced in thiol/disulfide homeostasis (TDH, a new biomarker of
systemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL.

Methods: This prospective
study analyzed the albumin, total thiol, native thiol, and disulfide levels and
disulfide-native thiol, disulfide-total thiol, and native thiol-total thiol
ratios before and after HBOT with standardizing pharmacotherapy using a new
colorimetric method in patients
with ISSNHL.

Results: 41 patients with
ISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study.
The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) had
hearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear.
There was a statistically significant decrease in the albumin (p<0.001),
total thiol (p<0.001), native thiol (p<0.001), and disulfide (p<0.001)
levels after treatment compared to baseline. There was no statistically
significant difference in the disulfide-native thiol (p=0.148), disulfide-total
thiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatment
compared to baseline.







Conclusion: Consequently,
this study demonstrated that the thiol-disulphide balance tended to shift
towards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL and
that patients with high oxidation level after treatment had better treatment
response.

Keywords

Idiopathic sudden sensorineural hearing loss oxidative stress thiol/disulfide homeostasis hyperbaric oxygen therapy

References

  • 1. Stachler RJ, Chandrasekhar SS, Archer SM, et al. Clinical practice guideline: sudden hearing loss. Otolaryngology—Head and Neck Surgery. 2012;146(3_suppl):S1-S35. doi: https://doi.org/10.1177/0194599812436449
  • 2. Chin CJ, Kathryn Dorman MSc M. Sudden sensorineural hearing loss. CMAJ. 2017;189(11):E437. doi: https://doi.org/10.1503/cmaj.161191
  • 3. Seidman MD, Vivek P. Intratympanic treatment of hearing loss with novel and traditional agents. Otolaryngol Clin N Am. 2004;37(5):973-90. doi: https://doi.org/10.1016/j.otc.2004.03.005
  • 4. Devarajan P, Savoca M, Castaneda MP, et al. Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways. Hearing research. 2002;174(1-2):45-54. doi: https://doi.org/10.1016/S0378-5955(02)00634-2
  • 5. Ciorba A, Gasparini P, Chicca M, et al. Reactive oxygen species in human inner ear perilymph. Acta oto-laryngologica. 2010;130(2):240-6. doi: https://doi.org/10.3109/00016480903143978
  • 6. Henderson D, Bielefeld EC, Harris KC, et al. The role of oxidative stress in noise-induced hearing loss. Ear and Hearing.. 2006;27(1):1-19. doi: https://doi.org/10.1097/01.aud.0000191942.36672.f3
  • 7. Labbé D, Teranishi M-a, Hess A, et al. Activation of caspase-3 is associated with oxidative stress in the hydropic guinea pig cochlea. Hearing research. 2005;202(1-2):21-7. doi: https://doi.org/10.1016/j.heares.2004.10.002
  • 8. Singh R, Wangemann P. Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model. Am J Physiol Renal Physiol. 2008;294(1):F139-F48. doi: https://doi.org/10.1152/ajprenal.00433.2007
  • 9. Antunes de Souza Chelminski Barreto M, Lima Losno Ledesma A, Costa Pires de Oliveira CA, et al. Intratympanic corticosteroid for sudden hearing loss: does it really work? Braz J Otorhinolaryngol. 2016;82(3). doi: https://doi.org/10.1016/j.bjorl.2015.06.007
  • 10. Paprocki J, Gackowska M, Pawłowska M, et al. The current use of hyperbaric oxygen treatment. Medycyna Rodzinna. 2016.
  • 11. Paprocki J, Pawłowska M, Sutkowy P, et al. The Oxidant–Antioxidant Equilibrium in the Blood of People with Sudden Sensorineural Hearing Loss After the First Hyperbaric Oxygen Therapy Session–A Preliminary Study. Polish Hyperbaric Research. 2017;61(4):15-24. doi: https://doi.org/10.1515/phr-2017-0018
  • 12. Solak I, Cetinkaya C, Gederet Y, et al. Effects of smoking on thiol/disulfide homeostasis. Eur Rev Med Pharmacol Sci. 2017;21:2477-82. doi: https://doi.org/10.26355/eurrev_201804_14842
  • 13. Cadenas E. Biochemistry of oxygen toxicity. Annu. Rev. Biochem. 1989;58(1):79-110. doi: https://doi.org/10.1146/annurev.bi.58.070189.000455
  • 14. Young I, Woodside J. Antioxidants in health and disease. Journal of clinical pathology. 2001;54(3):176-86. doi: https://doi.org/10.1136/jcp.54.3.176
  • 15. Biswas S, Chida AS, Rahman I. Redox modifications of protein–thiols: emerging roles in cell signaling. Biochemical pharmacology. 2006;71(5):551-64. doi: https://doi.org/10.1016/j.bcp.2005.10.044
  • 16. Prabhu A, Sarcar B, Kahali S, et al. Cysteine catabolism: a novel metabolic pathway contributing to glioblastoma growth. Cancer research. 2014;74(3):787-96. doi: https://doi.org/10.1158/0008-5472.CAN-13-1423
  • 17. WHO – World Health Organization. Grades of Hearing impairment 2007 [acesso em 26 de fevereiro de 2010] Disponível em: http://www.who.int/pbd/desfness/hearing_impairment_grades/en/index.html
  • 18. Gul F, Muderris T, Yalciner G, et al. A comprehensive study of oxidative stress in sudden hearing loss. Eur Arch Otorhinolaryngol. 2017;274(3):1301-8. doi: https://doi.org/10.1007/s00405-016-4301-1
  • 19. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical biochemistry. 2014;47(18):326-32. doi: https://doi.org/10.1016/j.clinbiochem.2014.09.026
  • 20. Thanan R, Oikawa S, Hiraku Y, et al. Oxidative stress and its significant roles in neurodegenerative diseases and cancer. Int. J. Mol. Sci. 2014;16(1):193-217. doi: https://doi.org/10.3390/ijms16010193
  • 21. Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radical Biology and Medicine. 2013;65:244-53. doi: https://doi.org/10.1016/j.freeradbiomed.2013.05.050
  • 22. Jones DP, Liang Y. Measuring the poise of thiol/disulfide couples in vivo. Free Radical Biology and Medicine. 2009;47(10):1329-38. doi: https://doi.org/10.1016/j.freeradbiomed.2009.08.021
  • 23. Quaranta N, De Ceglie V, D’Elia A. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review. Audiology research. 2016;6(1). doi: https://doi.org/10.4081/audiores.2016.151
  • 24. Aslan I, Oysu C, Veyseller B, et al. Does the addition of hyperbaric oxygen therapy to the conventional treatment modalities influence the outcome of sudden deafness? Otolaryngology—Head and Neck Surgery. 2002;126(2):121-6. doi: https://doi.org/10.1067/mhn.2002.121915
  • 25. Topuz E, Yigit O, Cinar U, et al. Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss? Eur Arch Oto Rhino Laryngol and Head & Neck. 2004;261(7):393-6. doi: https://doi.org/10.1007/s00405-003-0688-6
  • 26. Cavaleriu BD, Mârţu DV, Hriţcu L, et al. Idiopathic sudden hearing loss: Oxidative status before and after corticoid treatment. Arch. Biol. Sci. 2015;67(4):1297-302. doi: https://doi.org/10.2298/ABS150909106C
  • 27. Ohno K, Noguchi Y, Kawashima Y, et al. Secondary hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss in the subacute and chronic phases. J Med Dent Sci. 2010;57(2):127-32. doi: https://doi.org/10.11480/jmds.570201
  • 28. Khater A, El-Anwar MW, Nofal AA-F, et al. Sudden Sensorineural Hearing Loss: Comparative Study of Different Treatment Modalities. Int Arch Otorhinolaryngol. 2018;22:245–249. doi: https://doi.org/10.1055/s-0037-1605376

İdiopatik ani işitme kaybı olan hastaların tiyol/disülfit homeostazisi üzerine hiperbarik oksijen tedavisinin etkisi

Year 2018, Volume: 3 Issue: 3, 133 - 138, 04.10.2018

İbrahim Solak , Abdullah Arslan , Ruhusen Kutlu , Betul Kozanhan , Salim Neselioglu Ozcan Erel Cigdem Damla Cetinkaya Mehmet Ali Eryilmaz

https://doi.org/10.22391/fppc.470360

Abstract

Giriş: İdyopatik ani sensorinöral işitme kaybı (ISSNHL) en
önemli insan duyularından birinin işlev kaybına neden olabilen otolojik acil
bir durumdur. Son zamanlarda ISSNHL’ nda hiperbarik oksijen tedavisi (HBOT),
farmakoterapi ile birlikte popülerlik kazanmaktadır. Bu çalışmada ISSNHL olan
hastalarda farmakoterapi ile HBOT’nin sistemik oksidatif stresin yeni bir göstergesi
olan tiyol/disülfit homeostrazisinde (TDH) meydana getirdiği değişikliklerin
tespiti amaçlandı.

Yöntem: Bu prospektif
çalışmada ISSNHL olan hastalarda, çalışma başında ve standart tedaviyle
birlikte HBOT uygulandıktan sonra albümin, total tiyol, native tiyol, disülfit
düzeyleri ile disülfit /native tiyol, disülfit /total tiyol ve native
tiyol/total tiyol oranları yeni bir kolorimetrik yöntem kullanılarak analiz
edilmiştir.

Bulgular: Çalışmaya 14’ü
(%34,1) kadın 27’si (%65,9) erkek olmak üzere 41 ISSNH’ li hasta katıldı.
Hastaların yaş ortalaması 48,02±13,10 idi. Hastaların 24’ü (%58,5) sağ kulaktan
17’si (%41,5) sol kulaktan şikayeti vardı. Hastaların başlangıca göre tedavi
sonrasında native tiyol (p<0,001), total tiyol (p<0,001), disülfit  (p<0,001) ve albümin (p<0,001)
değerlerinde istatistiksel olarak anlamlı düşme olmuştur. Disülfit /native
tiyol (p=0,148), disülfit /total tiyol (p=0,172) ve native tiyol/total tiyol
(p=0,169) oranlarında tedavi sonrasında öncesine göre istatistiki olarak
anlamlı fark bulunamamıştır.







Sonuç: Sonuç olarak bu
çalışmada, ISSNHL hastalarda başlangıca göre HBOT ve medikal tedavi verildikten
sonra tiyol-disülfit dengesinin oksidasyon yönüne doğru kayma eğiliminde olduğu
ve tedavi sonrası oksidasyonun yüksek olduğu hastalarda tedaviye cevabın daha
iyi olduğu görülmektedir.

Keywords

İdiopatik ani sensorinöral işitme kaybı hiperbarik oksijen tedavisi oksidatif stres tiyol/disülfit homeostazisi hiperbarik oksijen tedavisi

References

  • 1. Stachler RJ, Chandrasekhar SS, Archer SM, et al. Clinical practice guideline: sudden hearing loss. Otolaryngology—Head and Neck Surgery. 2012;146(3_suppl):S1-S35. doi: https://doi.org/10.1177/0194599812436449
  • 2. Chin CJ, Kathryn Dorman MSc M. Sudden sensorineural hearing loss. CMAJ. 2017;189(11):E437. doi: https://doi.org/10.1503/cmaj.161191
  • 3. Seidman MD, Vivek P. Intratympanic treatment of hearing loss with novel and traditional agents. Otolaryngol Clin N Am. 2004;37(5):973-90. doi: https://doi.org/10.1016/j.otc.2004.03.005
  • 4. Devarajan P, Savoca M, Castaneda MP, et al. Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways. Hearing research. 2002;174(1-2):45-54. doi: https://doi.org/10.1016/S0378-5955(02)00634-2
  • 5. Ciorba A, Gasparini P, Chicca M, et al. Reactive oxygen species in human inner ear perilymph. Acta oto-laryngologica. 2010;130(2):240-6. doi: https://doi.org/10.3109/00016480903143978
  • 6. Henderson D, Bielefeld EC, Harris KC, et al. The role of oxidative stress in noise-induced hearing loss. Ear and Hearing.. 2006;27(1):1-19. doi: https://doi.org/10.1097/01.aud.0000191942.36672.f3
  • 7. Labbé D, Teranishi M-a, Hess A, et al. Activation of caspase-3 is associated with oxidative stress in the hydropic guinea pig cochlea. Hearing research. 2005;202(1-2):21-7. doi: https://doi.org/10.1016/j.heares.2004.10.002
  • 8. Singh R, Wangemann P. Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model. Am J Physiol Renal Physiol. 2008;294(1):F139-F48. doi: https://doi.org/10.1152/ajprenal.00433.2007
  • 9. Antunes de Souza Chelminski Barreto M, Lima Losno Ledesma A, Costa Pires de Oliveira CA, et al. Intratympanic corticosteroid for sudden hearing loss: does it really work? Braz J Otorhinolaryngol. 2016;82(3). doi: https://doi.org/10.1016/j.bjorl.2015.06.007
  • 10. Paprocki J, Gackowska M, Pawłowska M, et al. The current use of hyperbaric oxygen treatment. Medycyna Rodzinna. 2016.
  • 11. Paprocki J, Pawłowska M, Sutkowy P, et al. The Oxidant–Antioxidant Equilibrium in the Blood of People with Sudden Sensorineural Hearing Loss After the First Hyperbaric Oxygen Therapy Session–A Preliminary Study. Polish Hyperbaric Research. 2017;61(4):15-24. doi: https://doi.org/10.1515/phr-2017-0018
  • 12. Solak I, Cetinkaya C, Gederet Y, et al. Effects of smoking on thiol/disulfide homeostasis. Eur Rev Med Pharmacol Sci. 2017;21:2477-82. doi: https://doi.org/10.26355/eurrev_201804_14842
  • 13. Cadenas E. Biochemistry of oxygen toxicity. Annu. Rev. Biochem. 1989;58(1):79-110. doi: https://doi.org/10.1146/annurev.bi.58.070189.000455
  • 14. Young I, Woodside J. Antioxidants in health and disease. Journal of clinical pathology. 2001;54(3):176-86. doi: https://doi.org/10.1136/jcp.54.3.176
  • 15. Biswas S, Chida AS, Rahman I. Redox modifications of protein–thiols: emerging roles in cell signaling. Biochemical pharmacology. 2006;71(5):551-64. doi: https://doi.org/10.1016/j.bcp.2005.10.044
  • 16. Prabhu A, Sarcar B, Kahali S, et al. Cysteine catabolism: a novel metabolic pathway contributing to glioblastoma growth. Cancer research. 2014;74(3):787-96. doi: https://doi.org/10.1158/0008-5472.CAN-13-1423
  • 17. WHO – World Health Organization. Grades of Hearing impairment 2007 [acesso em 26 de fevereiro de 2010] Disponível em: http://www.who.int/pbd/desfness/hearing_impairment_grades/en/index.html
  • 18. Gul F, Muderris T, Yalciner G, et al. A comprehensive study of oxidative stress in sudden hearing loss. Eur Arch Otorhinolaryngol. 2017;274(3):1301-8. doi: https://doi.org/10.1007/s00405-016-4301-1
  • 19. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical biochemistry. 2014;47(18):326-32. doi: https://doi.org/10.1016/j.clinbiochem.2014.09.026
  • 20. Thanan R, Oikawa S, Hiraku Y, et al. Oxidative stress and its significant roles in neurodegenerative diseases and cancer. Int. J. Mol. Sci. 2014;16(1):193-217. doi: https://doi.org/10.3390/ijms16010193
  • 21. Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radical Biology and Medicine. 2013;65:244-53. doi: https://doi.org/10.1016/j.freeradbiomed.2013.05.050
  • 22. Jones DP, Liang Y. Measuring the poise of thiol/disulfide couples in vivo. Free Radical Biology and Medicine. 2009;47(10):1329-38. doi: https://doi.org/10.1016/j.freeradbiomed.2009.08.021
  • 23. Quaranta N, De Ceglie V, D’Elia A. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review. Audiology research. 2016;6(1). doi: https://doi.org/10.4081/audiores.2016.151
  • 24. Aslan I, Oysu C, Veyseller B, et al. Does the addition of hyperbaric oxygen therapy to the conventional treatment modalities influence the outcome of sudden deafness? Otolaryngology—Head and Neck Surgery. 2002;126(2):121-6. doi: https://doi.org/10.1067/mhn.2002.121915
  • 25. Topuz E, Yigit O, Cinar U, et al. Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss? Eur Arch Oto Rhino Laryngol and Head & Neck. 2004;261(7):393-6. doi: https://doi.org/10.1007/s00405-003-0688-6
  • 26. Cavaleriu BD, Mârţu DV, Hriţcu L, et al. Idiopathic sudden hearing loss: Oxidative status before and after corticoid treatment. Arch. Biol. Sci. 2015;67(4):1297-302. doi: https://doi.org/10.2298/ABS150909106C
  • 27. Ohno K, Noguchi Y, Kawashima Y, et al. Secondary hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss in the subacute and chronic phases. J Med Dent Sci. 2010;57(2):127-32. doi: https://doi.org/10.11480/jmds.570201
  • 28. Khater A, El-Anwar MW, Nofal AA-F, et al. Sudden Sensorineural Hearing Loss: Comparative Study of Different Treatment Modalities. Int Arch Otorhinolaryngol. 2018;22:245–249. doi: https://doi.org/10.1055/s-0037-1605376
There are 28 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research
Authors

İbrahim Solak 0000-0001-5311-0631

Abdullah Arslan 0000-0001-5575-326X

Ruhusen Kutlu 0000-0002-8502-0232

Betul Kozanhan 0000-0002-5097-9291

Salim Neselioglu 0000-0001-7571-5949

Ozcan Erel 0000-0002-2483-1939

Cigdem Damla Cetinkaya 0000-0002-6052-4645

Mehmet Ali Eryilmaz 0000-0002-5280-3943

Publication Date October 4, 2018
Submission Date October 14, 2018
Acceptance Date October 22, 2018
Published in Issue Year 2018Volume: 3 Issue: 3

Cite

APA Solak, İ., Arslan, A., Kutlu, R., Kozanhan, B., et al. (2018). Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. Family Practice and Palliative Care, 3(3), 133-138. https://doi.org/10.22391/fppc.470360
AMA Solak İ, Arslan A, Kutlu R, Kozanhan B, Neselioglu S, Erel O, Cetinkaya CD, Eryilmaz MA. Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. Fam Pract Palliat Care. October 2018;3(3):133-138. doi:10.22391/fppc.470360
Chicago Solak, İbrahim, Abdullah Arslan, Ruhusen Kutlu, Betul Kozanhan, Salim Neselioglu, Ozcan Erel, Cigdem Damla Cetinkaya, and Mehmet Ali Eryilmaz. “Effect of Hyperbaric Oxygen Therapy on thiol/Disulfide Homeostasis in Patients With Idiopathic Sudden Sensorineural Hearing Loss”. Family Practice and Palliative Care 3, no. 3 (October 2018): 133-38. https://doi.org/10.22391/fppc.470360.
EndNote Solak İ, Arslan A, Kutlu R, Kozanhan B, Neselioglu S, Erel O, Cetinkaya CD, Eryilmaz MA (October 1, 2018) Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. Family Practice and Palliative Care 3 3 133–138.
IEEE İ. Solak, A. Arslan, R. Kutlu, B. Kozanhan, S. Neselioglu, O. Erel, C. D. Cetinkaya, and M. A. Eryilmaz, “Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss”, Fam Pract Palliat Care, vol. 3, no. 3, pp. 133–138, 2018, doi: 10.22391/fppc.470360.
ISNAD Solak, İbrahim et al. “Effect of Hyperbaric Oxygen Therapy on thiol/Disulfide Homeostasis in Patients With Idiopathic Sudden Sensorineural Hearing Loss”. Family Practice and Palliative Care 3/3 (October 2018), 133-138. https://doi.org/10.22391/fppc.470360.
JAMA Solak İ, Arslan A, Kutlu R, Kozanhan B, Neselioglu S, Erel O, Cetinkaya CD, Eryilmaz MA. Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. Fam Pract Palliat Care. 2018;3:133–138.
MLA Solak, İbrahim et al. “Effect of Hyperbaric Oxygen Therapy on thiol/Disulfide Homeostasis in Patients With Idiopathic Sudden Sensorineural Hearing Loss”. Family Practice and Palliative Care, vol. 3, no. 3, 2018, pp. 133-8, doi:10.22391/fppc.470360.
Vancouver Solak İ, Arslan A, Kutlu R, Kozanhan B, Neselioglu S, Erel O, Cetinkaya CD, Eryilmaz MA. Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. Fam Pract Palliat Care. 2018;3(3):133-8.
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Family Practice and Palliative Care       ISSN 2458-8865       E-ISSN 2459-1505