Year 2020, Volume 5 , Issue 1, Pages 1 - 5 2020-01-22

The relationship between bone mineral density and hematological parameters in the geriatric age group
Geriatrik yaş grubunda kemik mineral dansitesinin hematolojik parametrelerle ilişkisi

Erhan ÖNALAN [1] , Yusuf GOKALP [2]


Introduction: As populations gradually become older, osteoporosis manifests itself as an important public health problem. Studies have shown that inflammation plays a critical role in the pathogenesis of osteoporosis. NLR (neutrophil to lymphocyte ratio) and PLR (platelet to lymphocyte ratio) are simple, non-invasive, and inexpensive markers of inflammation in malignancies and inflammatory diseases. This study aims to compare osteopenic, osteoporotic, and control subjects, who do not have other known diseases or a history of medication use, in terms of their NLR and PLR levels and evaluate the relationship between NLR, PLR levels and BMD.

Methods: This cross-sectional study included a total of 308 patients aged 65 or above. Total bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DEXA). Complete blood count (CBC), biomarkers of inflammation (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), glucose/lipid metabolism, and thyroid function test results were recorded.

Results: The osteoporosis group demonstrated higher NLR levels compared to the osteopenic and control groups (respectively 3.58 ± 4.22, 2.64 ± 1.99, and 2.36 ± 1.39), and this relationship between the groups was found to be statistically significant (p=0.025). Our data revealed higher sedimentation values for the osteoporosis group than for the osteopenic and healthy control groups with statistical significance (p=0.011).

Conclusions: The fact that individuals with geriatric osteoporosis demonstrate elevated NLR levels and that this elevation is also seen in sedimentation suggests that inflammation plays an important role in bone remodelling.

Giriş: Toplumların giderek yaşlanması sonucu osteoporoz önemli bir halk sağlığı sorunu olarak karşımıza çıkmaktadır. Yapılan çalışmalarda inflamasyonun osteoporozun patogenezinde kritik bir rol oynadığı gösterilmiştir. NLR (neutrophil to lyphocyte ratio ) ve PLR (platelet to lyphocyte ratiomaligniteler ve inflamatuar hastalıklarda basit, invazif olmayan ve uygun maliyetli bir inflamasyon belirtecidir. Bu çalışmanın amacı bilinen başka ek hastalığı ve ilaç kullanım öyküsü olmayan osteopenik, osteoporotik ve kontrol deneklerinde NLR ve PLR düzeylerini karşılaştırmak ve NLR, PLR düzeyleri ile KMY arasındaki ilişkiyi değerlendirmektir.

Yöntem: Bu kesitsel çalışmaya 65 yaş ve üzeri toplam 308 hasta dahil edildi. Tüm vücut BMD (bone mineral densıty) çift enerjili X ışını absorpsiyometrisi (DEXA) ile ölçülmüştür. Tam kan sayımı (CBC), inflamasyonun biyobelirteçleri C-reaktif protein (CRP), eritrosit sedimantasyon hızı (ESR), glukoz / lipid metabolizması, tiroid fonksiyon testleri kayıt altına alınmıştır.

Bulgular:  Osteoporoz grubunda, NLR düzeylerinin osteopenik ve kontrol grubuna göre yüksek olduğu bulundu (sırasıyla 3,58 ± 4,22,  2,64 ± 1,99 ve 2,36 ± 1,39) ve gruplar arasındaki bu ilişki istatistiksel olarak anlamlı saptandı ( p = 0,025). Elde ettiğimiz verilerde sedimantasyon değerleri osteoporoz grubunda osteopenik ve sağlıklı kontrol grubuna göre yüksek saptanmış olup istatistiksel olarakta anlamlıydı (p=0,011).

Sonuç: Yaşlı osteoporozu olan bireylerde NLR seviyelerinin yükselmesi ve bu yüksekliğin sedimantasyonda da olması kemik remodellinginde iltihaplanmanın önemli bir rol oynayabileceğini düşündürmektedir.

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Primary Language en
Subjects General and Internal Medicine
Published Date Apr 2020
Journal Section Original Research
Authors

Orcid: 0000-0001-5395-0390
Author: Erhan ÖNALAN (Primary Author)
Institution: Department of Internal Medicine, School of Medicine, Firat University, Elazig
Country: Turkey


Orcid: 0000-0003-2242-6937
Author: Yusuf GOKALP
Institution: Department of Internal Medicine, School of Medicine, Firat University, Elazig
Country: Turkey


Dates

Application Date : October 17, 2019
Acceptance Date : November 25, 2019
Publication Date : January 22, 2020

Bibtex @research article { fppc634197, journal = {Family Practice and Palliative Care}, issn = {2458-8865}, eissn = {2459-1505}, address = {}, publisher = {SERNEV}, year = {2020}, volume = {5}, pages = {1 - 5}, doi = {10.22391/fppc.634197}, title = {The relationship between bone mineral density and hematological parameters in the geriatric age group}, key = {cite}, author = {Önalan, Erhan and Gokalp, Yusuf} }
APA Önalan, E , Gokalp, Y . (2020). The relationship between bone mineral density and hematological parameters in the geriatric age group . Family Practice and Palliative Care , 5 (1) , 1-5 . DOI: 10.22391/fppc.634197
MLA Önalan, E , Gokalp, Y . "The relationship between bone mineral density and hematological parameters in the geriatric age group" . Family Practice and Palliative Care 5 (2020 ): 1-5 <http://www.fppc.com.tr/en/pub/issue/52039/634197>
Chicago Önalan, E , Gokalp, Y . "The relationship between bone mineral density and hematological parameters in the geriatric age group". Family Practice and Palliative Care 5 (2020 ): 1-5
RIS TY - JOUR T1 - The relationship between bone mineral density and hematological parameters in the geriatric age group AU - Erhan Önalan , Yusuf Gokalp Y1 - 2020 PY - 2020 N1 - doi: 10.22391/fppc.634197 DO - 10.22391/fppc.634197 T2 - Family Practice and Palliative Care JF - Journal JO - JOR SP - 1 EP - 5 VL - 5 IS - 1 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.634197 UR - https://doi.org/10.22391/fppc.634197 Y2 - 2019 ER -
EndNote %0 Family Practice and Palliative Care The relationship between bone mineral density and hematological parameters in the geriatric age group %A Erhan Önalan , Yusuf Gokalp %T The relationship between bone mineral density and hematological parameters in the geriatric age group %D 2020 %J Family Practice and Palliative Care %P 2458-8865-2459-1505 %V 5 %N 1 %R doi: 10.22391/fppc.634197 %U 10.22391/fppc.634197
ISNAD Önalan, Erhan , Gokalp, Yusuf . "The relationship between bone mineral density and hematological parameters in the geriatric age group". Family Practice and Palliative Care 5 / 1 (January 2020): 1-5 . https://doi.org/10.22391/fppc.634197
AMA Önalan E , Gokalp Y . The relationship between bone mineral density and hematological parameters in the geriatric age group. Fam Pract Palliat Care. 2020; 5(1): 1-5.
Vancouver Önalan E , Gokalp Y . The relationship between bone mineral density and hematological parameters in the geriatric age group. Family Practice and Palliative Care. 2020; 5(1): 1-5.