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Üst gastrointestinal kanamada ABO kan grubu ile kan transfüzyonu arasındaki ilişki

Year 2023, Volume: 8 Issue: 5, 130 - 133, 12.10.2023
https://doi.org/10.22391/fppc.1353468

Abstract

Giriş: Başta eritrositler olmak üzere birçok hücre ve dokuda bulunan ABO kan grubu (KG) antijenleri kardiyovasküler hastalıklar, enfeksiyonlar, maligniteler olmak üzere çok sayıda hastalıkla ilişkilendirilmiştir. ABO KG'nin duodenal ve gastrik ülserler, üst gastrointestinal kanaması (ÜGK) ile ilişkisi az sayıda çalışmada incelenmiş olup bu konudaki bilgiler kısıtlıdır. Çalışmamızın birincil amacı ABO KG ile ÜGK arasında bir ilişki olup olmadığını incelemek, ikincil amacıysa kanama sonrası kan transfüzyonu yapılan hastaların ABO KG ile ilişki olup olmadığını incelemektir.
Yöntem: Endoskopik inceleme ile ÜGK tanısı alan ve yatış yapılan hastaların A, B, AB, O KG ve Rh antijenlerinin prevalans değerleri, endoskopik işlem ve kan transfüzyon bilgileri kayıt altına alındı. Aynı dönemde ÜGK olmayan sağlıklı bireyler kontrol grubu (CG) olarak alındı. Endoskopik inceleme ile ÜGK olanlar çalışma grubunu (ÇG), en az 2 ünite kan transfüzyonu alanlar da transfüzyon grubunu (TG) oluşturdu.
Bulgular: ÇG 423 hasta, TG 383 hasta, CG 1650 hastadan oluştu. ÇG 0 KG olanlarda kanama riski daha yüksek tespit edilmiştir (OR 1.33 1.07-1.66 P=0.009). ÇG B KG olanlarda kanama riski daha düşük tespit edilmiştir (OR 0.77 0.63-0.95 P=0.014). TG O KG olanlarda kanama riski daha yüksek tespit edilmiştir (OR 1.35 1.08-1.70 P=0.009). TG B KG olanlarda kanama riski daha düşük tespit edilmiştir (OR 0.55 0.38-0.79 P=0.001). Diğer KG’ler A ve AB’de ÇG ve TG’de istatistiksel olarak anlamlı bir fark olmadığı gibi Rh’da da anlamlı bir fark tespit edilmemiştir.
Sonuç: 0 KG olan bireylerde ÜGK daha sık görülürken B KG olan bireylerde daha az rastlanmaktadır. Bu hastaların servis izlem sürelerinde kan transfüzyon ihtiyacı riski de 0 KG olanlarda daha fazla olurken B KG olanlarda daha az olmaktadır.
Anahtar Kelimeler: Kan grubu, kanama, transfüzyon

Ethical Statement

Local Ethics Committee Approval for this study was obtained from University of Health Sciences, Kocaeli Derince Training and Research Hospital, Clinical Research Ethics Committee (Decision no: 2019/102, decision date: 10.10.2019).

References

  • 1. Franchini M, Togliani T, Turdo R, Lucchini G, Bonfanti C, Giacomini I, et al. O blood type is a risk factor for upper gastrointestinal bleeding. J Thromb Thrombolysis. 2018;45(1):48-50. https://doi.org/10.1007/s11239-017-1576-z
  • 2. Abegaz SB. Human ABO blood groups and their associations with different diseases. Biomed Res Int. 2021;6629060. https://doi.org/10.1155/2021/6629060
  • 3. British Society of Gastroenterology Endoscopy C. Non-variceal upper gastrointestinal haemorrhage: guidelines. Gut. 2002;51 Suppl 4:iv1-6. http://dx.doi.org/10.1136/gut.51.suppl_4.iv1
  • 4. Kamboj AK, Hoversten P, Leggett CL. Upper gastrointestinal bleeding: etiologies and management. Mayo Clin Proc. 2019;94(4):697-703. https://doi.org/10.1016/j.mayocp.2019.01.022
  • 5. Evans DA, Horwich L, McConnell RB, Bullen MF. Influence of the ABO blood groups and secretor status on bleeding and on perforation of duodenal ulcer. Gut. 1968;9(3):319-22. https://doi.org/10.1136%2Fgut.9.3.319
  • 6. Rasmi Y, Sadreddini M, Peirovi T, Jamali M, Khosravifar F, Dadkhah A, et al. Frequency of ABO blood group in peptic ulcer disease in Iranian subjects. Pak J Biol Sci. 2009;12(13):991-3. https://doi.org/10.3923/pjbs.2009.991.993
  • 7. Merikas G, Christakopoulos P, Petropoulos E. Distribution of ABO blood groups in patients with ulcer disease. Its relationship to gastroduodenal bleeding. Am J Dig Dis. 1966;11(10):790-5. https://doi.org/10.1007/bf02233839
  • 8. Bayan K, Tuzun Y, Yilmaz S, Dursun M, Canoruc F. Clarifying the relationship between ABO/Rhesus blood group antigens and upper gastrointestinal bleeding. Dig Dis Sci. 2009;54(5):1029-34. https://doi.org/10.1007/s10620-008-0446-0
  • 9. Dentali F, Sironi AP, Ageno W, Bonfanti C, Crestani S, Frattini F, et al. Relationship between ABO blood group and hemorrhage: a systematic literature review and meta-analysis. Semin Thromb Hemost. 2013;39(1):72-82. https://doi.org/10.1055/s-0032-1329550
  • 10. General Directorate of Blood Services [2021 Activity report] (in Turkish). 2021. 1-110p https://www.kanver.org/Upload/Dokuman/Dosya/khgm-2021-28-06-2022-29983962.pdf (Access Date: October 9, 2023)
  • 11. Aird I, Bentall HH, Mehigan JA, Roberts JA. The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration. Br Med J. 1954;2(4883):315-21. https://doi.org/10.1136/bmj.2.4883.315
  • 12. Horwich L, Evans DA, McConnell RB, Donohoe WT. ABO blood groups in gastric bleeding. Gut. 1966;7(6):680-5. https://doi.org/10.1136/gut.7.6.680
  • 13. Mentis A, Blackwell CC, Weir DM, Spiliadis C, Dailianas A, Skandalis N. ABO blood group, secretor status and detection of Helicobacter pylori among patients with gastric or duodenal ulcers. Epidemiol Infect. 1991;106(2):221-9. https://doi.org/10.1017/s0950268800048366
  • 14. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci. 2012;49(4):137-49. https://doi.org/10.3109/10408363.2012.708647
  • 15. Garcia AA, van der Heijden JF, Meijers JC, Rosendaal FR, Reitsma PH. The relationship between ABO blood group and the risk of bleeding during vitamin K antagonist treatment. J Thromb Haemost. 2006;4(6):1418-20. https://doi.org/10.1111/j.1538-7836.2006.01962.x
  • 16. Pruissen DM, Rosendaal FR, Gorter JW, Garcia AA, Kappelle LJ, Algra A, et al. Haemostatic genetic variants, ABO blood group and bleeding risk during oral anticoagulant treatment after cerebral ischaemia of arterial origin. J Neurol. 2007;254(12):1660-5. https://doi.org/10.1007/s00415-007-0609-5
  • 17. Separham A, Dinparvar S, Savadi-Oskouei S, Pourafkari L, Baghbani-Oskouei A, Nader ND. Association of ABO blood types with ST resolution following thrombolysis in acute ST elevation myocardial infarction. J Cardiovasc Thorac Res. 2020;12(2):106-13. https://doi.org/10.34172/jcvtr.2020.18

The relationship between ABO blood group and blood transfusion in upper gastrointestinal bleeding

Year 2023, Volume: 8 Issue: 5, 130 - 133, 12.10.2023
https://doi.org/10.22391/fppc.1353468

Abstract

Introduction: ABO blood group (BG) antigens found in many cells and tissues, especially in erythrocytes, have been associated with many diseases including cardiovascular diseases, infections, and malignancies. The association of ABO BG with duodenal and gastric ulcers and upper gastrointestinal bleeding (UGB) has been investigated in few studies and the information on this subject is limited. The primary objective of our study is to examine whether there is an association between ABO BG and UGB, and the secondary objective is to examine whether there is an association between ABO BG and UGB in patients who received blood transfusions after bleeding.
Methods: The prevalence values of A, B, AB, 0 BG and Rh antigens, endoscopic procedure, and blood transfusion information of patients who were diagnosed with UGB by endoscopic examination and hospitalized were recorded. Healthy individuals without UGB in the same period were included as the control group (CG). Those who had UGB by endoscopic examination constituted the study group (SG) while those who received at least 2 units of blood transfusion formed the transfusion group (TG).
Results: SG consisted of 423 patients, TG included 383 patients, and CG had 1650 individuals. While the risk of bleeding was higher in SG patients with BG 0 (OR 1.33 1.07-1.66 P=0.009), the bleeding risk was lower in SG patients with BG B (OR 0.77 0.63-0.95 P=0.014). In addition, while the risk of bleeding was higher in TG patients with BG 0 (OR 1.35 1.08-1.70 P=0.009), the bleeding risk was lower in TG patients with BG B (OR 0.55 0.38-0.79 P=0.001). There was no statistically significant difference in SG, and TG in other BG A and AB and no significant difference in Rh.
Conclusion: While UGB is more common in individuals with BG 0, it is less common in individuals with BG B. The risk of need for blood transfusion during the follow-up period of these patients in the ward is higher in patients with BG 0 but lower in patients with BG B.
Keywords: Blood group, bleeding, transfusion

References

  • 1. Franchini M, Togliani T, Turdo R, Lucchini G, Bonfanti C, Giacomini I, et al. O blood type is a risk factor for upper gastrointestinal bleeding. J Thromb Thrombolysis. 2018;45(1):48-50. https://doi.org/10.1007/s11239-017-1576-z
  • 2. Abegaz SB. Human ABO blood groups and their associations with different diseases. Biomed Res Int. 2021;6629060. https://doi.org/10.1155/2021/6629060
  • 3. British Society of Gastroenterology Endoscopy C. Non-variceal upper gastrointestinal haemorrhage: guidelines. Gut. 2002;51 Suppl 4:iv1-6. http://dx.doi.org/10.1136/gut.51.suppl_4.iv1
  • 4. Kamboj AK, Hoversten P, Leggett CL. Upper gastrointestinal bleeding: etiologies and management. Mayo Clin Proc. 2019;94(4):697-703. https://doi.org/10.1016/j.mayocp.2019.01.022
  • 5. Evans DA, Horwich L, McConnell RB, Bullen MF. Influence of the ABO blood groups and secretor status on bleeding and on perforation of duodenal ulcer. Gut. 1968;9(3):319-22. https://doi.org/10.1136%2Fgut.9.3.319
  • 6. Rasmi Y, Sadreddini M, Peirovi T, Jamali M, Khosravifar F, Dadkhah A, et al. Frequency of ABO blood group in peptic ulcer disease in Iranian subjects. Pak J Biol Sci. 2009;12(13):991-3. https://doi.org/10.3923/pjbs.2009.991.993
  • 7. Merikas G, Christakopoulos P, Petropoulos E. Distribution of ABO blood groups in patients with ulcer disease. Its relationship to gastroduodenal bleeding. Am J Dig Dis. 1966;11(10):790-5. https://doi.org/10.1007/bf02233839
  • 8. Bayan K, Tuzun Y, Yilmaz S, Dursun M, Canoruc F. Clarifying the relationship between ABO/Rhesus blood group antigens and upper gastrointestinal bleeding. Dig Dis Sci. 2009;54(5):1029-34. https://doi.org/10.1007/s10620-008-0446-0
  • 9. Dentali F, Sironi AP, Ageno W, Bonfanti C, Crestani S, Frattini F, et al. Relationship between ABO blood group and hemorrhage: a systematic literature review and meta-analysis. Semin Thromb Hemost. 2013;39(1):72-82. https://doi.org/10.1055/s-0032-1329550
  • 10. General Directorate of Blood Services [2021 Activity report] (in Turkish). 2021. 1-110p https://www.kanver.org/Upload/Dokuman/Dosya/khgm-2021-28-06-2022-29983962.pdf (Access Date: October 9, 2023)
  • 11. Aird I, Bentall HH, Mehigan JA, Roberts JA. The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration. Br Med J. 1954;2(4883):315-21. https://doi.org/10.1136/bmj.2.4883.315
  • 12. Horwich L, Evans DA, McConnell RB, Donohoe WT. ABO blood groups in gastric bleeding. Gut. 1966;7(6):680-5. https://doi.org/10.1136/gut.7.6.680
  • 13. Mentis A, Blackwell CC, Weir DM, Spiliadis C, Dailianas A, Skandalis N. ABO blood group, secretor status and detection of Helicobacter pylori among patients with gastric or duodenal ulcers. Epidemiol Infect. 1991;106(2):221-9. https://doi.org/10.1017/s0950268800048366
  • 14. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci. 2012;49(4):137-49. https://doi.org/10.3109/10408363.2012.708647
  • 15. Garcia AA, van der Heijden JF, Meijers JC, Rosendaal FR, Reitsma PH. The relationship between ABO blood group and the risk of bleeding during vitamin K antagonist treatment. J Thromb Haemost. 2006;4(6):1418-20. https://doi.org/10.1111/j.1538-7836.2006.01962.x
  • 16. Pruissen DM, Rosendaal FR, Gorter JW, Garcia AA, Kappelle LJ, Algra A, et al. Haemostatic genetic variants, ABO blood group and bleeding risk during oral anticoagulant treatment after cerebral ischaemia of arterial origin. J Neurol. 2007;254(12):1660-5. https://doi.org/10.1007/s00415-007-0609-5
  • 17. Separham A, Dinparvar S, Savadi-Oskouei S, Pourafkari L, Baghbani-Oskouei A, Nader ND. Association of ABO blood types with ST resolution following thrombolysis in acute ST elevation myocardial infarction. J Cardiovasc Thorac Res. 2020;12(2):106-13. https://doi.org/10.34172/jcvtr.2020.18

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Original Research
Authors

Hüseyin KURT 0000-0003-4534-140X

Ahsen Banu TİRYAKİ 0000-0002-5556-065X

Burcu ÇİLEK BALİMRE 0000-0001-8000-3380

Şeyma Büşra MÜDERRİSOĞLU 0000-0003-3675-7577

Gökhan DİNDAR 0000-0003-1983-2790

Publication Date October 12, 2023
Submission Date September 1, 2023
Acceptance Date October 3, 2023
Published in Issue Year 2023Volume: 8 Issue: 5

Cite

APA KURT, H., TİRYAKİ, A. B., ÇİLEK BALİMRE, B., MÜDERRİSOĞLU, Ş. B., et al. (2023). The relationship between ABO blood group and blood transfusion in upper gastrointestinal bleeding. Family Practice and Palliative Care, 8(5), 130-133. https://doi.org/10.22391/fppc.1353468
AMA KURT H, TİRYAKİ AB, ÇİLEK BALİMRE B, MÜDERRİSOĞLU ŞB, DİNDAR G. The relationship between ABO blood group and blood transfusion in upper gastrointestinal bleeding. Fam Pract Palliat Care. October 2023;8(5):130-133. doi:10.22391/fppc.1353468
Chicago KURT, Hüseyin, Ahsen Banu TİRYAKİ, Burcu ÇİLEK BALİMRE, Şeyma Büşra MÜDERRİSOĞLU, and Gökhan DİNDAR. “The Relationship Between ABO Blood Group and Blood Transfusion in Upper Gastrointestinal Bleeding”. Family Practice and Palliative Care 8, no. 5 (October 2023): 130-33. https://doi.org/10.22391/fppc.1353468.
EndNote KURT H, TİRYAKİ AB, ÇİLEK BALİMRE B, MÜDERRİSOĞLU ŞB, DİNDAR G (October 1, 2023) The relationship between ABO blood group and blood transfusion in upper gastrointestinal bleeding. Family Practice and Palliative Care 8 5 130–133.
IEEE H. KURT, A. B. TİRYAKİ, B. ÇİLEK BALİMRE, Ş. B. MÜDERRİSOĞLU, and G. DİNDAR, “The relationship between ABO blood group and blood transfusion in upper gastrointestinal bleeding”, Fam Pract Palliat Care, vol. 8, no. 5, pp. 130–133, 2023, doi: 10.22391/fppc.1353468.
ISNAD KURT, Hüseyin et al. “The Relationship Between ABO Blood Group and Blood Transfusion in Upper Gastrointestinal Bleeding”. Family Practice and Palliative Care 8/5 (October 2023), 130-133. https://doi.org/10.22391/fppc.1353468.
JAMA KURT H, TİRYAKİ AB, ÇİLEK BALİMRE B, MÜDERRİSOĞLU ŞB, DİNDAR G. The relationship between ABO blood group and blood transfusion in upper gastrointestinal bleeding. Fam Pract Palliat Care. 2023;8:130–133.
MLA KURT, Hüseyin et al. “The Relationship Between ABO Blood Group and Blood Transfusion in Upper Gastrointestinal Bleeding”. Family Practice and Palliative Care, vol. 8, no. 5, 2023, pp. 130-3, doi:10.22391/fppc.1353468.
Vancouver KURT H, TİRYAKİ AB, ÇİLEK BALİMRE B, MÜDERRİSOĞLU ŞB, DİNDAR G. The relationship between ABO blood group and blood transfusion in upper gastrointestinal bleeding. Fam Pract Palliat Care. 2023;8(5):130-3.

Family Practice and Palliative Care       ISSN 2458-8865       E-ISSN 2459-1505