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Şizofreni hastalarında ortalama trombosit hacminin değerlendirilmesi

Yıl 2018, Cilt: 3 Sayı: 2, 102 - 107, 30.08.2018

Memduha Aydin , Bilge Cetin Ilhan Tuba Serife Elmas Yusuf Cokunlu Ibrahim Eren

https://doi.org/10.22391/fppc.401101
Cited By: 2

Öz



Giriş: Şizofreni hastalarında genel popülasyona kıyasla kardiyovasküler
hastalıklara daha sık rastlanmaktadır, mortalite oranı genel popülasyona göre
daha yüksektir. Şizofreni hastalarında artmış kardiyovasküler olayların
açıklamalarından biri de trombosit aktivitesinin artmasıdır. Trombositler
aterosklerotik lezyonların progresyonu, plak destabilizasyonu ve tromboz
oluşumu için gereklidir. Ortalama trombosit hacmi (MPV), trombosit büyüklüğünün
ve kardiyovasküler hastalıklarda artan platelet fonksiyonunun ve aktivasyonunun
iyi bir göstergesidir. Tam kan sayımı analizi sırasında MPV rutin olarak
bakılmaktadır. Bu çalışmanın amacı şizofreni hastalarının MPV değerlerini
değerlendirmektir.



Yöntem: Bu retrospektif çalışmada
psikiyatri kliniğine Ocak 2015 – Ocak 2017 
tarihleri arasında  ardışık olarak
başvurmuş olan şizofreni  hastalarının
hastane dosya kayıtları incelendi. Kişisel psikiyatrik öyküsü olmayan sağlıklı
bireyler kontrol grubu olarak alındı.

Bulgular: Psikiyatri polikliniğine
ardışık olarak başvuran toplam 100 (59 kadın, 41erkek) şizofreni hastası  ve 37 (20 kadın, 17 erkek) sağlıklı kontrol
bu retrospektif çalışmaya alındı. Hasta grubu ve sağlıklı kontrol grubu
arasında yaş (hasta grubu ve kontrol grubu ortalama yaş, sırasıyla 37,72 ve 35,03, p=0,081) ve cinsiyet bakımından anlamlı bir fark yoktu (p=0,603). Vücut kitle indexi (VKİ) hasta grubunda daha yüksek
olmasıyla gruplar arasında anlamlı fark bulunmuştur (p=0,001). MPV kontrol grubuna kıyasla hasta grubunda
anlamlı yüksek bulundu (hasta grubu ile kontrol grubu MPV sırayla; 10,34 fL ve
9,97 fL, p=0,041).  Platelet sayısı (PC) hasta grubunda anlamlı
düşük bulundu (hasta
grubu ile kontrol grubu platelet sayısı sırayla:
234,36 ve 267,38, p=0,008). MPV ve VKİ arasında herhangi
bir ilişki bulunmadı (p=0,354,
r=0,10), MPV ile  hastalık süresi
arasında herhangi bir ilişki bulunmadı (p=0,530,
r=0,06).







Sonuç: Sonuç olarak, bu çalışmada bir grup
şizofreni hastasında artmış MPV ve azalmış PC bulundu. Artmış MPV ve azalmış
PC, genel popülasyonda kardiyovasküler hastalıklar için risk faktörü olarak
değerlendirildiğinden, şizofrenide daha sık karşılaşılan kardiyovasküler
hastalıklar için risk faktörlerinin bir göstergesi olarak da düşünülebilir.

Anahtar Kelimeler

Kardiyovasküler hastalıklar ortalama trombosit hacmi şizofreni

Kaynakça

  • Schultz SK, Andreasen NC. Schizophrenia. Lancet 1999;353(9162):1425-1430. https://doi.org/10.1016/S0140-6736(98)07549-7
  • Leucht S, Burkard T, Henderson J, Maj M, Sartorius N. Physical illness and schizophrenia: a review of the literature. Acta Psychiatr Scand 2007;116(5):317-333. https://doi.org/10.1111/j.1600-0447.2007.01095.x
  • Ryan MC, Thakore JH. Physical consequences of schizophrenia and its treatment: The metabolic syndrome. Life Sci 2002;71:239–257. https://doi.org/10.1016/S0024-3205(02)01646-6
  • Dietrich-Muszalska A, Wachowicz B. Platelet haemostatic function in psychiatric disorders: Effects of antidepressants and antipsychotic drugs. World J Biol Psychiatry 2017;18(8):564-574. https://doi.org/10.3109/15622975.2016.1155748
  • Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: Is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003;9:177-190. https://doi.org/10.1177/107602960300900301
  • Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378-3384. https://doi.org/10.1172/JCI27196
  • Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001;22:1561-1571. https://doi.org/10.1053/euhj.2000.2515
  • Choi DH, Kang SH, Song H. Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease. Korean J Intern Med 2016;31(6):1009-1017. https://doi.org/10.3904/kjim.2016.078
  • Ha SI, Choi DH, Ki YJ, Yang JS, Park G, Chung JW, et al. Stroke prediction using mean platelet volume in patients with atrial fibrillation. Platelets 2011;22:408-414. https://doi.org/10.3109/09537104.2011.560306
  • Noris P, Melazzini F, Balduini CL. New roles for mean platelet volume measurement in the clinical practice? Platelets 2016;27(7):607-612. https://doi.org/10.1080/09537104.2016.1224828
  • Lee J, Powell V, Remington G. Mean platelet volume in schizophrenia unaltered after 1 year of clozapine exposure. Schizophr Res 2014;157:134-136. https://doi.org/10.1016/j.schres.2014.04.038
  • Wysokiński A, Szczepocka E. Platelet parameters (PLT, MPV, P-LCR) in patients with schizophrenia, unipolar depression and bipolar disorder. Psychiatry Res 2016;237:238-245. https://doi.org/10.1016/j.psychres.2016.01.034
  • Almis BH, Aksoy I. Mean platelet volume level in patients with generalized anxiety disorder. Psychiatry and Clinical Psychopharmacology 2018;28(1):43–47. https://doi.org/10.1080/24750573.2017.1385210
  • Kokacya MH, Copoglu US, Kivrak Y, Ari M, Sahpolat M, Ulutas KT. Increased mean platelet volume in patients with panic disorder. Neuropsychiatr Dis Treat 2015;11:2629-2633. https://doi.org/10.2147/NDT.S94147
  • Ransing RS, Patil B, Grigo O. Mean platelet volume and platelet distribution width level in patients with panic disorder. J Neurosci Rural Pract 2017;8(2):174–178. https://doi.org/10.4103/jnrp.jnrp_445_16
  • Zhou S, Liang X, Wang N, Shao L, Yu W, Liu M. Association of human platelet antigen polymorphisms with platelet count and mean platelet volume. Hematology 2018:27:1-5, https://doi.org/10.1080/10245332.2018.1445580
  • Smock KJ, Perkins SL. Thrombocytopenia: an update. Int J Lab Hematol 2014;36(3):269-278 https://doi.org/10.1111/ijlh.12214
  • Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010;8(1):148-156. https://doi.org/10.1111/j.1538-7836.2009.03584.x
  • Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, et al. Mean platelet volume on admission predicts impaired reperfusion and longterm mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 2005;46:284–290. https://doi.org/10.1016/j.jacc.2005.03.065
  • Yang A, Pizzulli L, Luderitz B. Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris. Thromb Res 2006;117:371–377. https://doi.org/10.1016/j.thromres.2005.04.004
  • Thompson CB, Jakubowski JA. The pathophysiology and clinical relevance of platelet heterogeneity. Blood 1988;72:1–8. PMID:3291975
  • McGrath J, Saha S, Chant D, Welham J. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev 2008;30:67-76. https://doi.org/10.1093/epirev/mxn001
  • van Winkel R, Rutten BP, Peerbooms O, Peuskens J, van Os J, De Hert M. MTHFR and risk of metabolic syndrome in patients with schizophrenia. Schizophr Res 2010;121:193–198. https://doi.org/10.1016/j.schres.2010.05.030
  • Bobes J, Arango C, Garcia-Garcia M, Rejas J. Healthy lifestyle habits and 10-year cardiovascular risk in schizophrenia spectrum disorders: An analysis of the impact of smoking tobacco in the CLAMORS schizophrenia cohort. Schizophr Res 2010;119:101–109. https://doi.org/10.1016/j.schres.2010.02.1030
  • Protopopova D, Masopust J, Maly R, Valis M, Bazant J. The prevalence of cardiometabolic risk factors and the ten-year risk of fatal cardiovascular events in patients with schizophrenia and related psychotic disorders. Psychiatr Danub 2012;24:307-313. PMID:23013637
  • Semiz M, Yücel H, Kavakçı O, Yıldırım O, Zorlu A, Yılmaz MB, et al. Atypical antipsychotic use is an independent predictor for the increased mean platelet volume in patients with schizophrenia: A preliminary study. J Res Med Sci 2013;18(7):561-566. PMID:24516487
  • Coban E, Yilmaz A, Sari R. The effect of weight loss on the mean platelet volume in obese patients. Platelets 2007;18:212-216. https://doi.org/10.1080/09537100600975362

Evaluation of mean platelet volume and platelet count in patients with schizophrenia

Yıl 2018, Cilt: 3 Sayı: 2, 102 - 107, 30.08.2018

Memduha Aydin , Bilge Cetin Ilhan Tuba Serife Elmas Yusuf Cokunlu Ibrahim Eren

https://doi.org/10.22391/fppc.401101
Cited By: 2

Öz

Introduction: Compared to the general
population, cardiovascular diseases are more common in schizophrenia patients
and the mortality rate is higher than the general population. One of the
explanations for increased cardiovascular events in patients with schizophrenia
is the increase in platelet activity. Platelets are essential for progression of
atherosclerotic lesions, plaque destabilization, and thrombus formation. Mean
platelet volume (MPV) is a measure of platelet size and a good marker of
platelet function and activation, which increases in cardiovascular diseases.
MPV is routinely reported during complete blood count analysis. The aim of the
present study was to evaluate MPV values of patients with schizophrenia.



Methods: In this retrospective study,
hospital-records of the patients who were consecutively admitted to psychiatry
inpatient clinic between January 2015 and January 2017 with the diagnosis of
schizophrenia were reviewed. Healthy subjects with no personal history of
psychiatric disorder were included as a control group. 



Results: A total of 100 (59 female, 41 male)
schizophrenic patients who had been consecutively admitted to the psychiatry
inpatient clinic and 37
(20 female, 17 male) healthy controls were included in this retrospective study. There
were no significant differences between the patient group and control group in
the terms of age (mean age patient group vs control group: 37.72 vs 35.03, p=0.081) and sex
(p=0.603). Body mass index (BMI) was
found to be significantly different between groups, higher in the patient group
(p=0.001). The MPV was found to be
significantly higher in patient group compared with the control group (MPV,
patient group vs control group: 10.34 fL vs 9.97 fL, p=0.041). Platelet count (PC) was significantly lower in the patient group (PC,
patient group vs control group: 234.36 vs 267.38, p=0.008) There
was no correlation between MPV and BMI (p=0.354, r=0.10), and
duration of illness (p=0.530,
r=0.06). 



Conclusions: As a result,
increased MPV and decreased PC were found in a group of schizophrenic patient
in this study. Since increased MPV and decreased PC are evaluated as risk
factors for cardiovascular diseases in the general population, they can also be considered as a
predictor of risk factors for cardiovascular diseases that are more frequently encountered in schizophrenia.

Anahtar Kelimeler

Cardiovascular diseases mean platelet volume schizophrenia

Kaynakça

  • Schultz SK, Andreasen NC. Schizophrenia. Lancet 1999;353(9162):1425-1430. https://doi.org/10.1016/S0140-6736(98)07549-7
  • Leucht S, Burkard T, Henderson J, Maj M, Sartorius N. Physical illness and schizophrenia: a review of the literature. Acta Psychiatr Scand 2007;116(5):317-333. https://doi.org/10.1111/j.1600-0447.2007.01095.x
  • Ryan MC, Thakore JH. Physical consequences of schizophrenia and its treatment: The metabolic syndrome. Life Sci 2002;71:239–257. https://doi.org/10.1016/S0024-3205(02)01646-6
  • Dietrich-Muszalska A, Wachowicz B. Platelet haemostatic function in psychiatric disorders: Effects of antidepressants and antipsychotic drugs. World J Biol Psychiatry 2017;18(8):564-574. https://doi.org/10.3109/15622975.2016.1155748
  • Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: Is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003;9:177-190. https://doi.org/10.1177/107602960300900301
  • Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378-3384. https://doi.org/10.1172/JCI27196
  • Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001;22:1561-1571. https://doi.org/10.1053/euhj.2000.2515
  • Choi DH, Kang SH, Song H. Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease. Korean J Intern Med 2016;31(6):1009-1017. https://doi.org/10.3904/kjim.2016.078
  • Ha SI, Choi DH, Ki YJ, Yang JS, Park G, Chung JW, et al. Stroke prediction using mean platelet volume in patients with atrial fibrillation. Platelets 2011;22:408-414. https://doi.org/10.3109/09537104.2011.560306
  • Noris P, Melazzini F, Balduini CL. New roles for mean platelet volume measurement in the clinical practice? Platelets 2016;27(7):607-612. https://doi.org/10.1080/09537104.2016.1224828
  • Lee J, Powell V, Remington G. Mean platelet volume in schizophrenia unaltered after 1 year of clozapine exposure. Schizophr Res 2014;157:134-136. https://doi.org/10.1016/j.schres.2014.04.038
  • Wysokiński A, Szczepocka E. Platelet parameters (PLT, MPV, P-LCR) in patients with schizophrenia, unipolar depression and bipolar disorder. Psychiatry Res 2016;237:238-245. https://doi.org/10.1016/j.psychres.2016.01.034
  • Almis BH, Aksoy I. Mean platelet volume level in patients with generalized anxiety disorder. Psychiatry and Clinical Psychopharmacology 2018;28(1):43–47. https://doi.org/10.1080/24750573.2017.1385210
  • Kokacya MH, Copoglu US, Kivrak Y, Ari M, Sahpolat M, Ulutas KT. Increased mean platelet volume in patients with panic disorder. Neuropsychiatr Dis Treat 2015;11:2629-2633. https://doi.org/10.2147/NDT.S94147
  • Ransing RS, Patil B, Grigo O. Mean platelet volume and platelet distribution width level in patients with panic disorder. J Neurosci Rural Pract 2017;8(2):174–178. https://doi.org/10.4103/jnrp.jnrp_445_16
  • Zhou S, Liang X, Wang N, Shao L, Yu W, Liu M. Association of human platelet antigen polymorphisms with platelet count and mean platelet volume. Hematology 2018:27:1-5, https://doi.org/10.1080/10245332.2018.1445580
  • Smock KJ, Perkins SL. Thrombocytopenia: an update. Int J Lab Hematol 2014;36(3):269-278 https://doi.org/10.1111/ijlh.12214
  • Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010;8(1):148-156. https://doi.org/10.1111/j.1538-7836.2009.03584.x
  • Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, et al. Mean platelet volume on admission predicts impaired reperfusion and longterm mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 2005;46:284–290. https://doi.org/10.1016/j.jacc.2005.03.065
  • Yang A, Pizzulli L, Luderitz B. Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris. Thromb Res 2006;117:371–377. https://doi.org/10.1016/j.thromres.2005.04.004
  • Thompson CB, Jakubowski JA. The pathophysiology and clinical relevance of platelet heterogeneity. Blood 1988;72:1–8. PMID:3291975
  • McGrath J, Saha S, Chant D, Welham J. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev 2008;30:67-76. https://doi.org/10.1093/epirev/mxn001
  • van Winkel R, Rutten BP, Peerbooms O, Peuskens J, van Os J, De Hert M. MTHFR and risk of metabolic syndrome in patients with schizophrenia. Schizophr Res 2010;121:193–198. https://doi.org/10.1016/j.schres.2010.05.030
  • Bobes J, Arango C, Garcia-Garcia M, Rejas J. Healthy lifestyle habits and 10-year cardiovascular risk in schizophrenia spectrum disorders: An analysis of the impact of smoking tobacco in the CLAMORS schizophrenia cohort. Schizophr Res 2010;119:101–109. https://doi.org/10.1016/j.schres.2010.02.1030
  • Protopopova D, Masopust J, Maly R, Valis M, Bazant J. The prevalence of cardiometabolic risk factors and the ten-year risk of fatal cardiovascular events in patients with schizophrenia and related psychotic disorders. Psychiatr Danub 2012;24:307-313. PMID:23013637
  • Semiz M, Yücel H, Kavakçı O, Yıldırım O, Zorlu A, Yılmaz MB, et al. Atypical antipsychotic use is an independent predictor for the increased mean platelet volume in patients with schizophrenia: A preliminary study. J Res Med Sci 2013;18(7):561-566. PMID:24516487
  • Coban E, Yilmaz A, Sari R. The effect of weight loss on the mean platelet volume in obese patients. Platelets 2007;18:212-216. https://doi.org/10.1080/09537100600975362
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makalesi (Original Article)
Yazarlar

Memduha Aydin 0000-0001-7679-6568

Bilge Cetin Ilhan 0000-0002-5941-8394

Tuba Serife Elmas 0000-0003-0325-8616

Yusuf Cokunlu 0000-0002-6170-8614

Ibrahim Eren 0000-0003-1626-7810

Yayımlanma Tarihi 30 Ağustos 2018
Gönderilme Tarihi 3 Mart 2018
Kabul Tarihi 22 Ağustos 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 3 Sayı: 2

Kaynak Göster

APA Aydin, M., Cetin Ilhan, B., Elmas, T. S., … Cokunlu, Y. (2018). Evaluation of mean platelet volume and platelet count in patients with schizophrenia. Family Practice and Palliative Care, 3(2), 102-107. https://doi.org/10.22391/fppc.401101
AMA Aydin M, Cetin Ilhan B, Elmas TS, Cokunlu Y, Eren I. Evaluation of mean platelet volume and platelet count in patients with schizophrenia. Fam Pract Palliat Care. Ağustos 2018;3(2):102-107. doi:10.22391/fppc.401101
Chicago Aydin, Memduha, Bilge Cetin Ilhan, Tuba Serife Elmas, Yusuf Cokunlu, ve Ibrahim Eren. “Evaluation of mean platelet volume and platelet count in patients with schizophrenia”. Family Practice and Palliative Care 3, sy. 2 (Ağustos 2018): 102-7. https://doi.org/10.22391/fppc.401101.
EndNote Aydin M, Cetin Ilhan B, Elmas TS, Cokunlu Y, Eren I (01 Ağustos 2018) Evaluation of mean platelet volume and platelet count in patients with schizophrenia. Family Practice and Palliative Care 3 2 102–107.
IEEE M. Aydin, B. Cetin Ilhan, T. S. Elmas, Y. Cokunlu, ve I. Eren, “Evaluation of mean platelet volume and platelet count in patients with schizophrenia”, Fam Pract Palliat Care, c. 3, sy. 2, ss. 102–107, 2018, doi: 10.22391/fppc.401101.
ISNAD Aydin, Memduha vd. “Evaluation of mean platelet volume and platelet count in patients with schizophrenia”. Family Practice and Palliative Care 3/2 (Ağustos2018), 102-107. https://doi.org/10.22391/fppc.401101.
JAMA Aydin M, Cetin Ilhan B, Elmas TS, Cokunlu Y, Eren I. Evaluation of mean platelet volume and platelet count in patients with schizophrenia. Fam Pract Palliat Care. 2018;3:102–107.
MLA Aydin, Memduha vd. “Evaluation of mean platelet volume and platelet count in patients with schizophrenia”. Family Practice and Palliative Care, c. 3, sy. 2, 2018, ss. 102-7, doi:10.22391/fppc.401101.
Vancouver Aydin M, Cetin Ilhan B, Elmas TS, Cokunlu Y, Eren I. Evaluation of mean platelet volume and platelet count in patients with schizophrenia. Fam Pract Palliat Care. 2018;3(2):102-7.

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 Kapak Resmi İndir

Family Practice and Palliative Care      ISSN 2458-8865       E-ISSN 2459-1505