Araştırma Makalesi
Akut böbrek hasarı olan hastalarda serum düzeltilmiş ve iyonize kalsiyum seviyelerinin karşılaştırılması
Öz
Giriş: Hastaneye yatırılan hastalarda akut böbrek hasarı (ABH) sık olarak görülmektedir (%1,92). ABH’lı hastalarda serum düzeltilmiş ve iyonize kalsiyum düzeylerinin acil hemodiyalizi öngörmedeki etkisi bilinmemektedir. Bu çalışmada acil serviste ABH tanısı alan hastalarda serum düzeltilmiş ve iyonize kalsiyum düzeylerini karşılaştırmayı amaçladık.
Yöntem: Çalışmamız retrospektif olarak planlandı. Grup 1: En az bir kez acil hemodiyaliz seansı alan ABH hastaları. Grup 2: Hemodiyalize girmeyen AKIN evre 1-3 olan hastalar. Hastaların başvuru anında serum düzeltilmiş ve iyonize kalsiyum, kreatinin ve albümin değerleri incelendi. Çalışmanın tüm verileri SPSS 19.0 ile kaydedildi. İstatistiksel anlamlılık için p <0,050 kabul edildi.
Bulgular: Serum düzeltilmiş kalsiyum düzeylerinin ortalaması grup 1'de grup 2'ye göre daha düşüktü ve fark istatistiksel olarak anlamlıydı (p <0,001). Kan gazındaki ortalama iyonize kalsiyum seviyeleri grup 1'de grup 2'ye göre daha düşüktü ve fark istatistiksel olarak anlamlıydı (p = 0,002).
Sonuç: ABH hastalarında acil hemodiyalizin öngörülmesinde serum düzeltilmiş ve iyonize kalsiyum düzeyleri faydalı olabilir.
Anahtar Kelimeler
Kaynakça
- 1. Liangos O, Wald R, O’Bell JW, Price L, Pereira BJ, Jaber BL. Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. Clin J Am Soc Nephrol 2006; 1(1):43–51. https://doi.org/10.2215/CJN.00220605
- 2. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16(11):3365–70. https://doi.org/10.1681/ASN.2004090740
- 3. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007;11(2): R31. https://doi.org/10.1186/cc5713
- 4. Kellum JA, Mehta RL, Levin A, Molitoris BA, Wranock DG, Shah SV, et al. Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi process. Clin J Am Soc Nephrol. 2008;3(3):887-94. https://doi.org/10.2215/CJN.04891107
- 5. Tuglular SZ. [Acute Problems in Calcium and Phosphorus in Renal Disease Setting] (in Turkish). Turk Clin J Nephrol-Special Topics 2010;3(1):50-5.
- 6. Thongprayoon C, Cheungpasitporn W, Mao MA, Sakhuja A, Erickson S. Admission Calcium levels and risk of acute kidney injury in hospitalised patients. Int J Clin Pract 2018;72(4):e13057. https://doi.org/10.1111/ijcp.13057
- 7. Khwaja A. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int. Supplements 2012;2:1-138. https://doi.org/10.1038/kisup.2012.6
- 8. Assadi F. Hypercalcemia: an evidence-based approach to clinical cases. Iran J Kidney Dis 2009;3(2):71-9. https://pubmed.ncbi.nlm.nih.gov/19395781/
- 9. Higaki M, Tanemoto M, Shiraishi T, Taniguchi K, Fujigaki Y, Uchida S. Acute Kidney Injury Facilitates Hypocalcemia by Exacerbating the Hyperphosphatemic Effect of Muscle Damage in Rhabdomyolysis. Nephron 2015;131(1):11-6. https://doi.org/10.1159/000437391
- 10. Akman C, Cakır DÜ, Bakirdogen S, Balcı S.The effect of serum calcium levels on uremic encephalopathy in patients with acute kidney injury in the emergency department. Medicina 2019;55(5):204. https://doi.org/10.3390/medicina55050204
- 11. Bellomo R, Kellum JA, Ronco C, Wald R, Martensonn J, Maiden M, et al. Acute kidney injury in sepsis. Intensive Care Med 2017; 43(6):816-28. https://doi.org/10.1007/s00134-017-4755-7
- 12. Shao M, Wang S, Parameswaran PK. Hypoalbuminemia: a risk factor for acute kidney injury development and progression to chronic kidney disease in critically ill patients. Int Urol Nephrol 2017;49(2):295-302. https://doi.org/10.1007/s11255-016-1453-2
- 13. Wiedermann CJ, Wiedermann W, Joannidis M. Causal relationship between hypoalbuminemia and acute kidney injury. World J Nephrol. 2017;6(4):176-87. https://doi.org/10.5527/wjn.v6.i4.176
- 14. Wiedermann CJ, Joannidis M. Nephroprotective Potential of Human Albumin Infusion: A Narrative Review. Gastroenterol Res Pract 2015; 912939:8 . http://dx.doi.org/10.1155/2015/912839
Yıl 2021,
Cilt: 6 Sayı: 2, 77 - 80, 05.05.2021
Öz
Introduction: Acute kidney injury (AKI) is common in hospitalized patients (1.92%). The effect of serum corrected and ionized calcium levels in predicting emergency hemodialysis in patients with AKI is unknown. In this study, we aimed to compare serum corrected and ionized calcium levels in patients who were diagnosed with AKI in the emergency service.
Methods: Our study was planned retrospectively. Group 1: Patients with AKI who underwent at least one session of emergency hemodialysis. Group 2: The patients with AKIN stage 1-3 who did not undergo hemodialysis. Serum corrected and ionized calcium, creatinine and albumin values of the patients at the time of admission were analyzed. All data of the study were recorded by SPSS 19.0. For statistical significance, p <0.050 was accepted.
Results: The mean serum corrected calcium levels were lower in group 1 than in group 2, and the difference was statistically significant (p <0.001). The mean ionized calcium levels in blood gas were lower in group 1 than in group 2, and the difference was statistically significant (p = 0.002).
Conclusions: Serum corrected, and ionized calcium levels can be useful in predicting emergency hemodialysis in patients with AKI.
Anahtar Kelimeler
Kaynakça
- 1. Liangos O, Wald R, O’Bell JW, Price L, Pereira BJ, Jaber BL. Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. Clin J Am Soc Nephrol 2006; 1(1):43–51. https://doi.org/10.2215/CJN.00220605
- 2. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16(11):3365–70. https://doi.org/10.1681/ASN.2004090740
- 3. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007;11(2): R31. https://doi.org/10.1186/cc5713
- 4. Kellum JA, Mehta RL, Levin A, Molitoris BA, Wranock DG, Shah SV, et al. Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi process. Clin J Am Soc Nephrol. 2008;3(3):887-94. https://doi.org/10.2215/CJN.04891107
- 5. Tuglular SZ. [Acute Problems in Calcium and Phosphorus in Renal Disease Setting] (in Turkish). Turk Clin J Nephrol-Special Topics 2010;3(1):50-5.
- 6. Thongprayoon C, Cheungpasitporn W, Mao MA, Sakhuja A, Erickson S. Admission Calcium levels and risk of acute kidney injury in hospitalised patients. Int J Clin Pract 2018;72(4):e13057. https://doi.org/10.1111/ijcp.13057
- 7. Khwaja A. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int. Supplements 2012;2:1-138. https://doi.org/10.1038/kisup.2012.6
- 8. Assadi F. Hypercalcemia: an evidence-based approach to clinical cases. Iran J Kidney Dis 2009;3(2):71-9. https://pubmed.ncbi.nlm.nih.gov/19395781/
- 9. Higaki M, Tanemoto M, Shiraishi T, Taniguchi K, Fujigaki Y, Uchida S. Acute Kidney Injury Facilitates Hypocalcemia by Exacerbating the Hyperphosphatemic Effect of Muscle Damage in Rhabdomyolysis. Nephron 2015;131(1):11-6. https://doi.org/10.1159/000437391
- 10. Akman C, Cakır DÜ, Bakirdogen S, Balcı S.The effect of serum calcium levels on uremic encephalopathy in patients with acute kidney injury in the emergency department. Medicina 2019;55(5):204. https://doi.org/10.3390/medicina55050204
- 11. Bellomo R, Kellum JA, Ronco C, Wald R, Martensonn J, Maiden M, et al. Acute kidney injury in sepsis. Intensive Care Med 2017; 43(6):816-28. https://doi.org/10.1007/s00134-017-4755-7
- 12. Shao M, Wang S, Parameswaran PK. Hypoalbuminemia: a risk factor for acute kidney injury development and progression to chronic kidney disease in critically ill patients. Int Urol Nephrol 2017;49(2):295-302. https://doi.org/10.1007/s11255-016-1453-2
- 13. Wiedermann CJ, Wiedermann W, Joannidis M. Causal relationship between hypoalbuminemia and acute kidney injury. World J Nephrol. 2017;6(4):176-87. https://doi.org/10.5527/wjn.v6.i4.176
- 14. Wiedermann CJ, Joannidis M. Nephroprotective Potential of Human Albumin Infusion: A Narrative Review. Gastroenterol Res Pract 2015; 912939:8 . http://dx.doi.org/10.1155/2015/912839
Toplam 14 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Acil Tıp |
| Bölüm | Araştırma Makalesi (Original Article) |
| Yazarlar | |
| Yayımlanma Tarihi | 5 Mayıs 2021 |
| Gönderilme Tarihi | 5 Ocak 2021 |
| Kabul Tarihi | 2 Nisan 2021 |
| Yayımlandığı Sayı | Yıl 2021Cilt: 6 Sayı: 2 |