Araştırma Makalesi
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Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study

Yıl 2022, Cilt 7, Sayı 1, 1 - 6, 17.03.2022
https://doi.org/10.22391/fppc.1028627

Öz

Introduction: Improving the health-related quality of life of patients with epilepsy has a prominent role in the management of sickness. In this study, we aim to compare health-related life quality (QOL) between male and female active epilepsy patients and investigate the clinical factors that may impair their quality of life.

Methods: Total 172 patients (82 female, 90 male) which are traced about their diagnosis of active epilepsy are included in this study. All of the subscales related to the Quality of Life in Epilepsy Inventory (QOLIE-31), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) are compared between the female and male patients with epilepsy. In addition, the clinical factors associated with the illness and the topics about whether there are relations between quality of life (QOL) and psychiatric symptoms or not are evaluated separately for both genders.

Results: It is examined that there is a considerably decrease in the subscales of female with epilepsy related to the overall (p= 0.054), social (p= 0.041) and cognitive functions (p= 0.043) of the QOLIE-31 test compared to male with epilepsy. It is determined in the correlation analysis of male patients that all of the QOLIE-31 subscales are negatively correlated with seizure frequency. Negatively correlation with seizure frequency is examined in all of the categories except for the subscales related to the emotional well-being and medication effects. Additionally, it is confirmed that there is a significant correlation between BDI and BAI scores and seizure frequency in both groups.

Conclusion: These results suggest that the rise in epileptic seizure frequency may affect women’s social and cognitive skills in the course of the disease. Moreover, it is seen that the rise in epileptic seizure frequency is the most important clinical factor associated with the decline in QOL of people with epilepsy. Hence, gender-focused studies and clinical approaches may cause the improvement in the treatment modalities and QOL in epilepsy.

Keywords: Epilepsy, Gender, Active Epilepsy, Health-related Quality of Life 

Kaynakça

  • 1. Beydoun A, DuPont S, Zhou D, Matta M, Nagire V, Lagae L. Current role of carbamazepine and oxcarbazepine in the management of epilepsy. Seizure. 2020;83:251-63 https://doi.org/10.1016/j.seizure.2020.10.018.
  • 2. Thurman DJ, Beghi E, Begley CE, Berg AT, Buchhalter JR, Ding D, et al. ILAE commission on epidemiology: standards for epidemiologic studies and surveillance of epilepsy. Epilepsia. 201;52(7):2-26 https://doi.org/10.1111/j.1528-1167.2011.03121.x.
  • 3. Taylor RS, Sander JW, Taylor RJ, Baker G, Predictors of health-related quality of life and costs in adults with epilepsy: a systematic review. Epilepsia 2011;52(12):2168–80 https://doi.org/10.1111/j.1528-1167.2011.03213.x.
  • 4. Schachter SC. Improving quality of life beyond seizure control. Epileptic Disord. 2008;10(2):191.
  • 5. Birbeck GL, Hays RD, Cui X, Vickrey BG. Seizure reduction and quality of life improvements in people with epilepsy. Epilepsia. 2002;43(5):535-8 https://doi.org/10.1046/j.1528-1157.2002.32201.x.
  • 6. Basaran S, Tas Hİ. Predictive factors of quality of life in temporal and extratemporal lobe epilepsy: association with affective temperament profiles and psychiatric comorbidities. Arq Neuropsiquiatr. 2021;79(9):799-807 https://doi.org/10.1590/0004-282X-ANP-2020-0437
  • 7. Yue L, Yu PM, Zhao DH, Wu DY, Zhu GX, Wu XY, et al. Determinants of quality of life in people with epilepsy and their gender differences. Epilepsy Behav 2011;22(4):692–6 https://doi.org/10.1016/j.yebeh.2011.08.022.
  • 8. Devinsky O, Vickrey BG, Cramer J, Perrine K, Hermann B, Meador K, et al. Development of the quality of life in epilepsy inventory. Epilepsia. 1995;36(11):1089-104 https://doi.org/10.1111/j.1528-1157.1995.
  • 9. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475-82 https://doi.org/10.1111/epi.12550.
  • 10. Mollaoglu M, Durna Z, Bolayir E. Validity and reliability of the quality of life in epilepsy inventory (QOLIE-31) for Turkey. Noro Psikiyatr Ars. 2015;52(3):289-95 https://doi.org/10.5152/npa.2015.8727.
  • 11. Beck AT, Ward CH, Mendelson M, Mock J,Erbaugh J. An inventory for measuring depression. Arch. Gen. Psychiatry. 1961;4(6):561–71 https://doi.org/10.1001/archpsyc.1961.01710120031004.
  • 12. Hisli N. [The validity and reliability of the Beck depression inventory among university students] (in Turkish) Turk J Psychology 1989;7:3-13
  • 13. Beck AT, Brown G, Epstein N, Steer RA. An inventory for measuring clinical anxiety - psychometric properties. J Consult Clin Psychol 1988;56:893-7.
  • 14. Ulusoy M, Sahin NH, Erkmen H. Turkish version of the beck anxiety inventory: psychometric properties. J Cogn Psychother 1998;12:163-72
  • 15. Saadi A, Patenaude B, Mateen FJ. Quality of life in epilepsy-31 inventory (QOLIE-31) scores: A global comparison. Epilepsy Behav 2016; 65:13-7 https://doi.org/10.1016/j.yebeh.2016.09.032.
  • 16. Choi-Kwon S, Chung C, Kim H, Lee S, Yoon S, Kho H, et al. Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea. Acta Neurol Scand 2003;108(6):428–34 https://doi.org/10.1046/j.1600-0404.2003.00151.x.
  • 17. Lee SA, Kim SJ, Han NE, Lee SM, No YJ. Gender differences in factors associated with resilience for health-related quality of life in persons with epilepsy. Epilepsy Behav. 2021;11(5):107-10 https://doi.org/10.1016/j.yebeh.2020.107710.
  • 18. Alanis-Guevara I, Peña E, Corona T, López-Ayala T, López-Meza E, López-Gómez M. Sleep disturbances, socioeconomic status, and seizure control as main predictors of quality of life in epilepsy. Epilepsy Behav 2005;7(3):481–5 https://doi.org/10.1016/j.yebeh.2005.06.010.
  • 19. Chen HF, Tsai YF, Hsi MS, Chen JC. Factors affecting quality of life in adults with epilepsy in Taiwan: A cross-sectional, correlational study. Epilepsy Behav 2016;58:26–32 https://doi.org/10.1016/j.yebeh.2016.02.019.
  • 20. Thomas SV, Koshy S, Nair CR, Sarma SP. Frequent seizures and polytherapy can impair quality of life in persons with epilepsy. Neurol India. 2005;53(1):46-50 https://doi.org/10.4103/0028-3886.15054.
  • 21. Dourado M, Alonso N, Martins H, Oliveira C, Vancini R, Lima C, et al. Quality of life and the self-perception impact of epilepsy in three different epilepsy types. J. epilepsy clin. neurophysiol. 2007;13(4):191-6 https://doi.org/10.1590/S167626492007000400009.
  • 22. Guekht AB, Mitrokhina TV, Lebedeva AV, Dzugaeva FK, Milchakova LE, Lokshina OB, et al. Factors influencing on quality of life in people with epilepsy. Seizure. 2007;16(2):128-33 https://doi.org/10.1016/j.seizure.2006.10.011.
  • 23. Melikyan E, Guekht A, Milchakova L, Lebedeva A, Bondareva I, Gusev E. Health-related quality of life in Russian adults with epilepsy: the effect of socio-demographic and clinical factors. Epilepsy Behav. 2012;25(4):670-5 https://doi.org/10.1016/j.yebeh.2012.09.042.
  • 24. Piperidou C, Karlovasitou A, Triantafyllou N, Dimitrakoudi E, Terzoudi A, Mavraki E, et al. Association of demographic, clinical and treatment variables with quality of life of patients with epilepsy in Greece. Qual Life Res. 2008; 17(7):987-96 https://doi.org/10.1007/s11136-008-9375-9.
  • 25. Bala A, Szantroch M, Gleinert A, Rysz A, Marchel A. Differences in quality of life of women and men with drug-resistant epilepsy in Poland. Epilepsy Behav. 2016;60:94-98 https://doi.org/10.1016/j.yebeh.2016.04.041.
  • 26. Albert PR. Why is depression more prevalent in women? J Psychiatry Neurosci. 2015;40(4):219-21 https://doi.org/10.1503/jpn.150205.
  • 27. McLean CP, Asnaani A, Litz BT, Hofmann SG. Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res. 2011;45(8):1027-35 https://doi.org/10.1016/j.jpsychires.2011.03.006.
  • 28. Gaus V, Kiep H, Holtkamp M, Burkert S, Kendel F. Gender differences in depression, but not in anxiety in people with epilepsy. Seizure (2015)32:37– 42 https://doi.org/10.1016/j.seizure.2015.07.012.
  • 29. Liu Z, Yin R, Fan Z, Fan H, Wu H, Shen B, et al. Gender differences in associated and predictive factors of anxiety and depression in people with epilepsy. Front Psychiatry. 2020;10 (11): 670 https://doi.org/10.3389/fpsyt.2020.00670

Aktif epilepsi hastalarında sağlıkla ilişkili yaşam kalitesinin cinsiyetler arası farklılıkları ve klinik faktörler ile ilişkisinin belirleyicileri: Retrospektif kesitsel bir çalışma

Yıl 2022, Cilt 7, Sayı 1, 1 - 6, 17.03.2022
https://doi.org/10.22391/fppc.1028627

Öz

Giriş: P Epilepsi hastalarında sağlıkla ilişkili yaşam kalitesinin düzeltilmesi hastalığın yönetiminde oldukça önemli bir role sahiptir. Biz bu çalışmada, aktif epilepsisi olan kadın ve erkek bireylerde sağlıkla ilişkili yaşam kalitesini karşılaştırmayı ve yaşam kalitesini bozabilecek klinik faktörleri değerlendirmeyi amaçladık.

Yöntem: Bu çalışmaya aktif epilepsi tanısı ile takip edilen toplam 172 hasta (82 kadın, 90 erkek) dahil edildi. Epilepside Yaşam Kalitesi Ölçeği-31 (QOLIE-31), Beck Depresyon ölçeği (BDI), ve Beck Anksiyete ölçeğine (BAI) ait tüm skorlar kadın ve erkek epilepsi hastaları arasında karşılaştırıldı. Buna ek olarak, hastalığa ilişkin faktörler, yaşam kalitesi ve psikiyatrik semptomlar arasında ilişki olup olmadığı her iki cinsiyet için ayrı ayrı değerlendirildi.

Bulgular: Epilepsisi olan kadınlarda QOLIE-31 testinin total (p= 0,054), sosyal (p= 0,041) ve kognitif fonksiyonlara (p= 0,043) ait skorlarında erkek hastalara göre anlamlı düzeyde düşüklük olduğu izlendi. Epilepsili erkek hastaların korelasyon analizinde QOLIE-31 testinin tüm skorlarının nöbet sıklığı ile negatif yönde korele olduğu saptandı. Kadın epilepsi hastalarında ise emosyonel iyilik ve ilaç etkilerine ait skorlar haricindeki tüm kategorilerde nöbet sıklığı ile negatif yönde korelasyon izlendi. Ayrıca her iki grupta depresyon ve anksiyete semptomları ile artmış ile nöbet sıklığı arasında anlamlı ilişki olduğu tespit edildi.

Sonuç: Bu bulgular epileptik nöbet sıklığındaki artışın kadın epilepsili hastaların sosyal ve kognitif yetilerini etkileyebileceğini göstermektedir. Ayrıca, artmış nöbet sıklığının, epilepsili bireylerin yaşam kalitesinde düşüş ile ilişkili en önemli klinik değişken olduğu izlenmiştir. Bu nedenle epilepsi hastalarında cinsiyet farklılıklarını değerlendiren çalışma ve klinik yaklaşımlar, tedavi modalitelerinde ve hastaların yaşam kalitesinde düzelmeye neden olabilir.

Anahtar kelimeler: epilepsi, cinsiyet, aktif epilepsi, sağlıkla ilişkili yaşam kalitesi

Kaynakça

  • 1. Beydoun A, DuPont S, Zhou D, Matta M, Nagire V, Lagae L. Current role of carbamazepine and oxcarbazepine in the management of epilepsy. Seizure. 2020;83:251-63 https://doi.org/10.1016/j.seizure.2020.10.018.
  • 2. Thurman DJ, Beghi E, Begley CE, Berg AT, Buchhalter JR, Ding D, et al. ILAE commission on epidemiology: standards for epidemiologic studies and surveillance of epilepsy. Epilepsia. 201;52(7):2-26 https://doi.org/10.1111/j.1528-1167.2011.03121.x.
  • 3. Taylor RS, Sander JW, Taylor RJ, Baker G, Predictors of health-related quality of life and costs in adults with epilepsy: a systematic review. Epilepsia 2011;52(12):2168–80 https://doi.org/10.1111/j.1528-1167.2011.03213.x.
  • 4. Schachter SC. Improving quality of life beyond seizure control. Epileptic Disord. 2008;10(2):191.
  • 5. Birbeck GL, Hays RD, Cui X, Vickrey BG. Seizure reduction and quality of life improvements in people with epilepsy. Epilepsia. 2002;43(5):535-8 https://doi.org/10.1046/j.1528-1157.2002.32201.x.
  • 6. Basaran S, Tas Hİ. Predictive factors of quality of life in temporal and extratemporal lobe epilepsy: association with affective temperament profiles and psychiatric comorbidities. Arq Neuropsiquiatr. 2021;79(9):799-807 https://doi.org/10.1590/0004-282X-ANP-2020-0437
  • 7. Yue L, Yu PM, Zhao DH, Wu DY, Zhu GX, Wu XY, et al. Determinants of quality of life in people with epilepsy and their gender differences. Epilepsy Behav 2011;22(4):692–6 https://doi.org/10.1016/j.yebeh.2011.08.022.
  • 8. Devinsky O, Vickrey BG, Cramer J, Perrine K, Hermann B, Meador K, et al. Development of the quality of life in epilepsy inventory. Epilepsia. 1995;36(11):1089-104 https://doi.org/10.1111/j.1528-1157.1995.
  • 9. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475-82 https://doi.org/10.1111/epi.12550.
  • 10. Mollaoglu M, Durna Z, Bolayir E. Validity and reliability of the quality of life in epilepsy inventory (QOLIE-31) for Turkey. Noro Psikiyatr Ars. 2015;52(3):289-95 https://doi.org/10.5152/npa.2015.8727.
  • 11. Beck AT, Ward CH, Mendelson M, Mock J,Erbaugh J. An inventory for measuring depression. Arch. Gen. Psychiatry. 1961;4(6):561–71 https://doi.org/10.1001/archpsyc.1961.01710120031004.
  • 12. Hisli N. [The validity and reliability of the Beck depression inventory among university students] (in Turkish) Turk J Psychology 1989;7:3-13
  • 13. Beck AT, Brown G, Epstein N, Steer RA. An inventory for measuring clinical anxiety - psychometric properties. J Consult Clin Psychol 1988;56:893-7.
  • 14. Ulusoy M, Sahin NH, Erkmen H. Turkish version of the beck anxiety inventory: psychometric properties. J Cogn Psychother 1998;12:163-72
  • 15. Saadi A, Patenaude B, Mateen FJ. Quality of life in epilepsy-31 inventory (QOLIE-31) scores: A global comparison. Epilepsy Behav 2016; 65:13-7 https://doi.org/10.1016/j.yebeh.2016.09.032.
  • 16. Choi-Kwon S, Chung C, Kim H, Lee S, Yoon S, Kho H, et al. Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea. Acta Neurol Scand 2003;108(6):428–34 https://doi.org/10.1046/j.1600-0404.2003.00151.x.
  • 17. Lee SA, Kim SJ, Han NE, Lee SM, No YJ. Gender differences in factors associated with resilience for health-related quality of life in persons with epilepsy. Epilepsy Behav. 2021;11(5):107-10 https://doi.org/10.1016/j.yebeh.2020.107710.
  • 18. Alanis-Guevara I, Peña E, Corona T, López-Ayala T, López-Meza E, López-Gómez M. Sleep disturbances, socioeconomic status, and seizure control as main predictors of quality of life in epilepsy. Epilepsy Behav 2005;7(3):481–5 https://doi.org/10.1016/j.yebeh.2005.06.010.
  • 19. Chen HF, Tsai YF, Hsi MS, Chen JC. Factors affecting quality of life in adults with epilepsy in Taiwan: A cross-sectional, correlational study. Epilepsy Behav 2016;58:26–32 https://doi.org/10.1016/j.yebeh.2016.02.019.
  • 20. Thomas SV, Koshy S, Nair CR, Sarma SP. Frequent seizures and polytherapy can impair quality of life in persons with epilepsy. Neurol India. 2005;53(1):46-50 https://doi.org/10.4103/0028-3886.15054.
  • 21. Dourado M, Alonso N, Martins H, Oliveira C, Vancini R, Lima C, et al. Quality of life and the self-perception impact of epilepsy in three different epilepsy types. J. epilepsy clin. neurophysiol. 2007;13(4):191-6 https://doi.org/10.1590/S167626492007000400009.
  • 22. Guekht AB, Mitrokhina TV, Lebedeva AV, Dzugaeva FK, Milchakova LE, Lokshina OB, et al. Factors influencing on quality of life in people with epilepsy. Seizure. 2007;16(2):128-33 https://doi.org/10.1016/j.seizure.2006.10.011.
  • 23. Melikyan E, Guekht A, Milchakova L, Lebedeva A, Bondareva I, Gusev E. Health-related quality of life in Russian adults with epilepsy: the effect of socio-demographic and clinical factors. Epilepsy Behav. 2012;25(4):670-5 https://doi.org/10.1016/j.yebeh.2012.09.042.
  • 24. Piperidou C, Karlovasitou A, Triantafyllou N, Dimitrakoudi E, Terzoudi A, Mavraki E, et al. Association of demographic, clinical and treatment variables with quality of life of patients with epilepsy in Greece. Qual Life Res. 2008; 17(7):987-96 https://doi.org/10.1007/s11136-008-9375-9.
  • 25. Bala A, Szantroch M, Gleinert A, Rysz A, Marchel A. Differences in quality of life of women and men with drug-resistant epilepsy in Poland. Epilepsy Behav. 2016;60:94-98 https://doi.org/10.1016/j.yebeh.2016.04.041.
  • 26. Albert PR. Why is depression more prevalent in women? J Psychiatry Neurosci. 2015;40(4):219-21 https://doi.org/10.1503/jpn.150205.
  • 27. McLean CP, Asnaani A, Litz BT, Hofmann SG. Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res. 2011;45(8):1027-35 https://doi.org/10.1016/j.jpsychires.2011.03.006.
  • 28. Gaus V, Kiep H, Holtkamp M, Burkert S, Kendel F. Gender differences in depression, but not in anxiety in people with epilepsy. Seizure (2015)32:37– 42 https://doi.org/10.1016/j.seizure.2015.07.012.
  • 29. Liu Z, Yin R, Fan Z, Fan H, Wu H, Shen B, et al. Gender differences in associated and predictive factors of anxiety and depression in people with epilepsy. Front Psychiatry. 2020;10 (11): 670 https://doi.org/10.3389/fpsyt.2020.00670

Ayrıntılar

Birincil Dil İngilizce
Konular Genel ve Dahili Tıp
Yayınlanma Tarihi Mar 2022
Bölüm Araştırma Makalesi (Original Article)
Yazarlar

Şehnaz BAŞARAN (Sorumlu Yazar)
Department of Neurology, Kocaeli Derince Health Research Center, University of Health Sciences, Kocaeli
0000-0001-9475-9664
Türkiye

Yayımlanma Tarihi 17 Mart 2022
Başvuru Tarihi 26 Kasım 2021
Kabul Tarihi 24 Ocak 2022
Yayınlandığı Sayı Yıl 2022, Cilt 7, Sayı 1

Kaynak Göster

Bibtex @araştırma makalesi { fppc1028627, journal = {Family Practice and Palliative Care}, issn = {2458-8865}, eissn = {2459-1505}, address = {}, publisher = {Yusuf Haydar ERTEKİN}, year = {2022}, volume = {7}, number = {1}, pages = {1 - 6}, doi = {10.22391/fppc.1028627}, title = {Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study}, key = {cite}, author = {Başaran, Şehnaz} }
APA Başaran, Ş. (2022). Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study . Family Practice and Palliative Care , 7 (1) , 1-6 . DOI: 10.22391/fppc.1028627
MLA Başaran, Ş. "Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study" . Family Practice and Palliative Care 7 (2022 ): 1-6 <http://www.fppc.com.tr/tr/pub/issue/68637/1028627>
Chicago Başaran, Ş. "Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study". Family Practice and Palliative Care 7 (2022 ): 1-6
RIS TY - JOUR T1 - Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study AU - Şehnaz Başaran Y1 - 2022 PY - 2022 N1 - doi: 10.22391/fppc.1028627 DO - 10.22391/fppc.1028627 T2 - Family Practice and Palliative Care JF - Journal JO - JOR SP - 1 EP - 6 VL - 7 IS - 1 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.1028627 UR - https://doi.org/10.22391/fppc.1028627 Y2 - 2022 ER -
EndNote %0 Family Practice and Palliative Care Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study %A Şehnaz Başaran %T Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study %D 2022 %J Family Practice and Palliative Care %P 2458-8865-2459-1505 %V 7 %N 1 %R doi: 10.22391/fppc.1028627 %U 10.22391/fppc.1028627
ISNAD Başaran, Şehnaz . "Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study". Family Practice and Palliative Care 7 / 1 (Mart 2022): 1-6 . https://doi.org/10.22391/fppc.1028627
AMA Başaran Ş. Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study. Fam Pract Palliat Care. 2022; 7(1): 1-6.
Vancouver Başaran Ş. Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study. Family Practice and Palliative Care. 2022; 7(1): 1-6.
IEEE Ş. Başaran , "Gender differences in health-related quality of life of patients with active epilepsy and clinical factors that are signs of their associations: a retrospective cross-sectional study", Family Practice and Palliative Care, c. 7, sayı. 1, ss. 1-6, Mar. 2022, doi:10.22391/fppc.1028627

AİLE HEKİMLİĞİ ve PALYATİF BAKIM       ISSN 2458-8865       E-ISSN 2459-1505

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